Редактирование: TNK1 (раздел)

==Publications==

{{medline-entry
|title=Role of [[CLU]], [[PICALM]], and [[TNK1]] Genotypes in Aging With and Without Alzheimer's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28631188
|abstract=Healthy and impaired cognitive aging may be associated to different prevalences of single-nucleotide polymorphisms (SNPs). In a multicenter case-control association study, we studied the SNPs rs11136000 (clusterin, [[CLU]]), rs541458 (phosphatidylinositol binding clatrin assembly protein, [[PICALM]]), and rs1554948 (transcription factor A, and tyrosine kinase, non-receptor, 1, [[TNK1]]) according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80  years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients. In NoCI subjects, a regression analysis suggested a relationship between age and [[TNK1]] genotypes, with the [[TNK1]]-A/A genotype frequency that increased with higher age, and resulting in a different distribution of the [[TNK1]]-A allele. In AD patients, a regression analysis suggested a relationship between age and [[PICALM]] genotypes and [[TNK1]] genotypes, with the [[PICALM]]-T/C and [[TNK1]]-A/A genotype frequencies that decreased with increasing age. A resulting difference in the distribution of [[PICALM]]-C allele and [[TNK1]]-A allele was also observed. The [[TNK1]]-A allele was overrepresented in NoCI subjects than in AD patients in age groups 2 and 3. These results confirmed after adjustment for apolipoprotein E polymorphism, which suggested a different role of [[PICALM]] and [[TNK1]] in healthy and impaired cognitive aging. More studies, however, are needed to confirm the observed associations.
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Alleles
* Alzheimer Disease
* Clusterin
* Cohort Studies
* Female
* Fetal Proteins
* Gene Frequency
* Genetic Predisposition to Disease
* Humans
* Male
* Middle Aged
* Monomeric Clathrin Assembly Proteins
* Polymorphism, Single Nucleotide
* Protein-Tyrosine Kinases
|keywords=* Alzheimer’s disease
* Biogerontology
* Brain aging
* Cognition
* Dementia
* Genetics
|full-text-url=https://sci-hub.do/10.1007/s12035-017-0547-x
}}