Редактирование: PRRX1 (раздел)

==Publications==

{{medline-entry
|title=A [[SIRT1]]-centered circuitry regulates breast cancer stemness and metastasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30038266
|abstract=Cancer stem cell (CSC)-dictated intratumor heterogeneity accounts for the majority of drug-resistance and distant metastases of breast cancers. Here, we identify a [[SIRT1]]-[[PRRX1]]-[[KLF4]]-ALDH1 circuitry, which couples CSCs, chemo-resistance, metastasis and aging. Pro-longevity protein [[SIRT1]] deacetylates and stabilizes the epithelial-to-mesenchymal-transition (EMT) inducer [[PRRX1]], which inhibits the transcription of core stemness factor [[KLF4]]. Loss of [[SIRT1]] destabilizes [[PRRX1]], disinhibits [[KLF4]], and activates the transcription of ALDH1, which induces and functionally marks CSCs, resulting in chemo-resistance and metastatic relapse. Clinically, the level of [[PRRX1]] is positively linked to [[SIRT1]], whereas [[KLF4]] is reversely correlated. Importantly, [[KLF4]] inhibitor Kenpaullone sensitizes breast cancer cells and xenograft tumors to Paclitaxel and improves therapeutic effects. Our findings delineate a [[SIRT1]]-centered circuitry that regulates CSC origination, and targeting this pathway might be a promising therapeutic strategy.
|mesh-terms=* Aging
* Aldehyde Dehydrogenase 1 Family
* Animals
* Breast Neoplasms
* Cell Line, Tumor
* Drug Resistance, Neoplasm
* Female
* Gene Expression Regulation, Neoplastic
* Homeodomain Proteins
* Humans
* Isoenzymes
* Kruppel-Like Transcription Factors
* Mice
* Mice, Nude
* Neoplasm Invasiveness
* Neoplastic Stem Cells
* Retinal Dehydrogenase
* Signal Transduction
* Sirtuin 1
* Xenograft Model Antitumor Assays

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283862
}}