Редактирование: NQO2 (раздел)

==Publications==

{{medline-entry
|title=The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase ([[NQO2]]).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28346733
|abstract=Dihydronicotinamide riboside:quinone oxidoreductase ([[NQO2]]) is an enzyme that performs reduction reactions involved in antioxidant defense. We hypothesized that [[NQO2]] hepatic drug clearance would develop in children over time, similar to [[NQO1]]. Using human liver cytosol (n = 117), the effects of age, sex, ethnicity, and weight on [[NQO2]] expression and activity were probed. No significant correlations were observed. Biochemical activity of [[NQO2]] was as high at birth as in adults (0.23 ± 0.04 nmol/min/mg protein, mean ± SEM, range 0-1.83). In contrast, modeled hepatic clearance through the [[NQO2]] pathway was up to 10% of adult levels at birth, reaching predicted adult levels (0.3 ± 0.03 L/h) at 14 years of age. Comparisons between [[NQO1]] and [[NQO2]] in the same livers showed that neither protein (P = 0.32) nor activity (P = 0.23) correlated, confirming both orthologs are independently regulated. Because hepatic clearance through [[NQO2]] does not mature until teenage years, compounds detoxified by this enzyme may be more deleterious in children.
|mesh-terms=* Aging
* Female
* Humans
* Liver
* Male
* NAD(P)H Dehydrogenase (Quinone)
* Quinone Reductases
|keywords=* antioxidants
* drug metabolism
* in vitro-in vivo extrapolation
* pediatric
* physiologically based pharmacokinetic modeling
|full-text-url=https://sci-hub.do/10.1002/jbt.21921
}}