Редактирование: HLA-DQB1 (раздел)

==Publications==

{{medline-entry
|title=Identification of new genetic variants of [[HLA-DQB1]] associated with human longevity and lipid homeostasis-a cross-sectional study in a Chinese population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29129831
|abstract=Healthy longevity has been an unremitting pursuit of human, but its genetic and the environment causes are still unclear. As longevity population is a good healthy aging model for understanding how the body begin aging and the process of aging, and plasma lipids metabolism and balance is a very important to life maintain and physiologic functional turnover. It is important to explore how the effect of genetic variants associated long-life individuals on lipids metabolism and balance. Therefore, we developed a comparative study based population which contains 2816 longevity and 2819 control. Through whole-exome sequencing and sanger sequencing genotypes, we identified four new single nucleotide polymorphisms of [[HLA-DQB1]](major histocompatibility complex, class II, DQ beta 1), rs41542812 rs1049107 rs1049100 rs3891176([i]P [/i]=0.048-2.811×10  for allele frequencies), associated with longevity in Chinese Longevity Cohort. Further, by analysis of the longevity-variants linked to blood lipids, we identified [[HLA-DQB1]] rs1049107, T-carriers ([i]P [/i]=0.006, OR: 11.277; [i]P [/i]=9.095×10 , OR: 0.025; [i]P [/i]=0.047, OR: 1.901) and [[HLA-DQB1]] rs1049100, T-carriers ([i]P [/i]=1.799×10-6, OR: 0.028) associated with lipid homeostasis in long lived individuals. Our finding showed that longevity and lipid homeostasis were associated with [[HLA-DQB1]] and suggested that immune gene variants could act on both new function of maintaining the homeostasis and anti-aging in longevity.
|mesh-terms=* Adult
* Aged, 80 and over
* Asian Continental Ancestry Group
* Case-Control Studies
* Chi-Square Distribution
* China
* Computational Biology
* Cross-Sectional Studies
* Databases, Genetic
* Female
* Gene Frequency
* Genetic Association Studies
* HLA-DQ beta-Chains
* Haplotypes
* Health Status
* Homeostasis
* Humans
* Lipid Metabolism
* Lipids
* Longevity
* Male
* Middle Aged
* Odds Ratio
* Phenotype
* Polymorphism, Single Nucleotide
|keywords=* Chinese population
* HLA-DQB1
* human longevity
* lipid phenotypes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723689
}}
{{medline-entry
|title=[Clinical and genetic characteristics of long-livers in Moscow region].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24640693
|abstract=In Moscow region long-livers we have studied distribution of [[LPL]], [[CETP]], [[APOE]], [[F2]], [[F5]], [[F7]], F13, [[FGB]], [[ITGA2]], [[ITGB3]], PAI-1, [[MTHFR]], [[MTRR]], [[HLA-DRB1]], [[HLA-DQA1]], [[HLA-DQB1]] genes polymorphisms, associated with predisposition to age pathology. Long-livers are characterized by favorable course of cardiovascular diseases accompanied by certain genetic factors. We have established that genotype H-H- of [[LPL]], allele epsilon2 of [[APOE]], genotype CC of [[MTHFR]] (677C > T), genotype TC of [[ITGB3]], genotype GA of [[FGB]], [[HLA-DRB1]]*11 positively correlate with longevity.
|mesh-terms=* Aged
* Aged, 80 and over
* Alleles
* Cardiovascular Diseases
* Female
* Gene Frequency
* Genetic Markers
* Genetic Predisposition to Disease
* Genotype
* Humans
* Longevity
* Male
* Moscow
* Polymorphism, Genetic
* Prevalence
* Urban Population


}}