Редактирование: HBB (раздел)

==Publications==

{{medline-entry
|title=Induction of immunotoxicity in mice by polyhalogenated biphenyls.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/3092783
|abstract=Acute administration of Aroclor-1254 (500 mg/kg) or 3,4,5,3',4',5'-hexabromobiphenyl ([[HBB]]) (2-6 mg/kg) IP, profoundly inhibited the plaque forming response to subsequent challenge with sheep erythrocytes in Ah locus positive (C57Bl/6N or B6C3F1N) mice. These studies showed: the immunotoxicity results paralleled enzyme induction results insofar as [[HBB]] was approximately 100 times more potent than Aroclor 1254; neither Aroclor nor [[HBB]] treatment caused significant induction in the Ah locus negative DBA/2N mice; when B6C3F1 mice were challenged with sheep red blood cells (SRBC) 6 or 16 weeks post Aroclor 1254 treatment, substantial recovery of a PFC response was observed; when these compounds were administered to older (76-week-old) (B6C3F1 mice, severe depression of a PFC response was observed. In contrast to its profound depression of a PFC response, Aroclor-1254 (up to 1250 mg/kg) caused slight increases in lymphocyte proliferation induced by either T or B cell mitogens. A single 500 mg/kg dose of Aroclor-1254 also suppressed the ability of recipient B6C3F1 animals to reject a challenge with either the syngenic fibrosarcoma (PYB6) or the gram negative pathogen (Listeria monocytogenes).
|mesh-terms=* Aging
* Animals
* Aroclors
* Chlorodiphenyl (54% Chlorine)
* Cyclophosphamide
* Cytochrome P-450 Enzyme System
* Dealkylation
* Fibrosarcoma
* Hemolytic Plaque Technique
* Immunity
* Listeria monocytogenes
* Lymphocyte Activation
* Mice
* Mice, Inbred C3H
* Mice, Inbred C57BL
* Mice, Inbred DBA
* Polychlorinated Biphenyls

|full-text-url=https://sci-hub.do/10.1007/BF00286726
}}