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Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Contains: LVV-hemorphin-7; Spinorphin]


Induction of immunotoxicity in mice by polyhalogenated biphenyls.

Acute administration of Aroclor-1254 (500 mg/kg) or 3,4,5,3',4',5'-hexabromobiphenyl (HBB) (2-6 mg/kg) IP, profoundly inhibited the plaque forming response to subsequent challenge with sheep erythrocytes in Ah locus positive (C57Bl/6N or B6C3F1N) mice. These studies showed: the immunotoxicity results paralleled enzyme induction results insofar as HBB was approximately 100 times more potent than Aroclor 1254; neither Aroclor nor HBB treatment caused significant induction in the Ah locus negative DBA/2N mice; when B6C3F1 mice were challenged with sheep red blood cells (SRBC) 6 or 16 weeks post Aroclor 1254 treatment, substantial recovery of a PFC response was observed; when these compounds were administered to older (76-week-old) (B6C3F1 mice, severe depression of a PFC response was observed. In contrast to its profound depression of a PFC response, Aroclor-1254 (up to 1250 mg/kg) caused slight increases in lymphocyte proliferation induced by either T or B cell mitogens. A single 500 mg/kg dose of Aroclor-1254 also suppressed the ability of recipient B6C3F1 animals to reject a challenge with either the syngenic fibrosarcoma (PYB6) or the gram negative pathogen (Listeria monocytogenes).

MeSH Terms

  • Aging
  • Animals
  • Aroclors
  • Chlorodiphenyl (54% Chlorine)
  • Cyclophosphamide
  • Cytochrome P-450 Enzyme System
  • Dealkylation
  • Fibrosarcoma
  • Hemolytic Plaque Technique
  • Immunity
  • Listeria monocytogenes
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Polychlorinated Biphenyls