Редактирование: ALKBH2 (раздел)

==Publications==

{{medline-entry
|title=ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30338756
|abstract=ALKB-8 is a 2-oxoglutarate-dependent dioxygenase homologous to bacterial AlkB, which oxidatively demethylates DNA substrates. The mammalian AlkB family contains AlkB homologues denominated [[ALKBH1]] to 8 and [[FTO]]. The C. elegans genome includes five AlkB-related genes, homologues of [[ALKBH1]], 4, 6, 7, and 8, but lacks homologues of [[ALKBH2]], 3, and 5 and [[FTO]]. [[ALKBH8]] orthologues differ from other AlkB family members by possessing an additional methyltransferase module and an RNA binding N-terminal module. The [[ALKBH8]] methyltransferase domain generates the wobble nucleoside 5-methoxycarbonylmethyluridine from its precursor 5-carboxymethyluridine and its (R)- and (S)-5-methoxycarbonylhydroxymethyluridine hydroxylated forms in tRNA Arg/UCG and tRNA Gly/UCC. The [[ALKBH8]]/ALKB-8 methyltransferase domain is highly similar to yeast TRM9, which selectively modulates translation of mRNAs enriched with [[AGA]] and [[GAA]] codons under both normal and stress conditions. In this report, we studied the role of alkb-8 in C. elegans. We show that downregulation of alkb-8 increases detection of lysosome-related organelles visualized by Nile red in vivo. Reversely, forced expression of alkb-8 strongly decreases the detection of this compartment. In addition, overexpression of alkb-8 applied in a pulse during the L1 larval stage increases the C. elegans lifespan.
|mesh-terms=* Aging
* AlkB Enzymes
* Animals
* Animals, Genetically Modified
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Dioxygenases
* Down-Regulation
* Embryo, Nonmammalian
* Gene Expression Regulation, Developmental
* Green Fluorescent Proteins
* Ketoglutaric Acids
* Larva
* Longevity
* Lysosomes
* Methyltransferases
* Operon
* Promoter Regions, Genetic
* RNA Interference
* S-Adenosylmethionine


}}
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