Редактирование: CSNK1G2

Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2) [CK1G2]

==Publications==

{{medline-entry
|title=Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33206046
|abstract=Casein kinases are a large family of intracellular serine/threonine kinases that control a variety of cellular signaling functions. Here we report that a member of casein kinase 1 family, casein kinase 1G2, [[CSNK1G2]], binds and inhibits the activation of receptor-interacting kinase 3, [[RIPK3]], thereby attenuating [[RIPK3]]-mediated necroptosis. The binding of [[CSNK1G2]] to [[RIPK3]] is triggered by auto-phosphorylation at serine 211/threonine 215 sites in its C-terminal domain. [[CSNK1G2]]-knockout mice showed significantly enhanced necroptosis response and premature aging of their testis, a phenotype that was rescued by either double knockout of the [i]Ripk3[/i] gene or feeding the animal with a [[RIPK1]] kinase inhibitor-containing diet. Moreover, [[CSNK1G2]] is also co-expressed with [[RIPK3]] in human testis, and the necroptosis activation marker phospho-[[MLKL]] was observed in the testis of old (>80) but not young men, indicating that the testis-aging program carried out by the [[RIPK3]]-mediated and [[CSNK1G2]]-attenuated necroptosis is evolutionarily conserved between mice and men.

|keywords=* aging
* cell biology
* mouse
* necroptosis
* protein kinase
* reproductivity
* testis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673785
}}