TAF1

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Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250) [BA2R] [CCG1] [CCGS] [TAF2A]

Publications[править]

Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice.

TATA-box binding protein associated factor 1 (TAF1) protein is the largest and the essential component of the TFIID complex in the pathway of RNA polymerase II-mediated gene transcription, and it regulates transcription of a large number of genes related to cell division. The neuron-specific isoform of the TAF1 gene (N-TAF1), which we reported previously, may have an essential role in neurons through transcriptional regulation of many neuron-specific genes. In the present study, we cloned the full-length cDNA that encodes the mouse homologue of N-TAF1 (N-Taf1) protein. By carrying out of real time RT-PCR, we investigated the expression analysis of the N-Taf1 mRNA in mouse tissues and cell lines. As well as the human N-TAF1, the N-Taf1 showed limited expression in the brain and neuroblastoma, whereas Taf1 expressed elsewhere. Furthermore, in mouse embryo head or mouse brain, mRNA expression of TAF1 changes dramatically during development but N-Taf1 showed sustained expression. Our result suggests that the N-Taf1 gene has an important role in non-dividing neuronal cell rather than in cell division and proliferation during neurogenesis.

MeSH Terms

  • Aging
  • Animals
  • Base Sequence
  • Brain
  • Cell Division
  • Cell Line, Tumor
  • Cell Proliferation
  • Cloning, Molecular
  • Embryo, Mammalian
  • Exons
  • Gene Expression Regulation, Developmental
  • Head
  • Histone Acetyltransferases
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Neurogenesis
  • Neurons
  • Open Reading Frames
  • Protein Isoforms
  • RNA, Messenger
  • TATA-Binding Protein Associated Factors
  • Transcription Factor TFIID