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Kinesin light chain 1 (KLC 1) [KLC] [KNS2]


Variability in the kinesin light chain 1 gene may influence risk of age-related cataract.

Kinesin-mediated cargo vesicle transport is fundamental to the maintenance of a proper lens fiber structure, which is essential for the transparency of the lens. Here, we test the hypothesis that the rs8702 polymorphism in the kinesin light chain 1 gene (KLC1), previously linked to Alzheimer disease (AD), may play a role in cataractogenesis. Patients with nuclear (n=76), cortical (n=154), posterior subcapsular (n=117), and mixed (n=148) cataract as well as 183 controls were analyzed for the KLC1 rs8702 polymorphism using the dynamic allele-specific hybridization (DASH) technique. The GG genotype of rs8702 was significantly over-represented among cataract patients as compared to controls (63% versus 52%, respectively, p=0.008) and associated with an age-adjusted odds ratio for cataract development of 1.61 (95% confidence interval 1.12-2.31). This association was not confined to any particular cataract type. The KLC1 gene may be a novel susceptibility gene for age-related cataract.

MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Alleles
  • Cataract
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Logistic Models
  • Male
  • Microtubule-Associated Proteins
  • Middle Aged
  • Nucleic Acid Hybridization
  • Odds Ratio
  • Polymorphism, Genetic
  • Smoking