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Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC (EC (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha)


The Hip Morphology Changes with Ageing in Asian Population.

This study aims to determine the changing in hip anatomy parameters with age and reveals the reason for the extorsion of lower extremity in the aged. Retrospective study. One hundred and forty patients who had received imaging check of the femur and acetabulum between October 2013 and October 2016 were included in this study. The femoral neck torsion angle (FNTA), neck-shaft angle (NSA), and acetabular anteversion angle (AVA) were measured by an experienced orthopedic surgeon. All the patients' demographic and physical characteristics including age, sex, body laterality, height, and weight were recorded. The Student [i]t[/i]-test, two-way ANOVA, Pearson correlation, and multiple linear regression were used for the statistical analysis. The mean age for male and female was 45.01±15.38 and 49.30±17.63 years, respectively. Outcomes revealed that the NSA on the right side of the body, 133.46±4.46° in male and 134.36±4.71° in female, was statistically higher than the left side. Female FNTA had significantly higher values than male ([i]P[/i]<0.01). Two-way ANOVA reveals that FNTA and AVA were correlated with age (P<0.05) but not weight, height, or BMI. NSA was correlated with age, weight, and BMI (P<0.05) but not height. Multiple linear regression analysis showed that only age made an independent contribution to NSA. The NSA and FNTA of Asian population may have an obvious decrease whereas AVA increases with ageing, which reveals the reason for the extorsion of lower extremity with elderly. During hip-related surgery in elderly patients, more attention should be paid to these lower extremity anatomic changes.

MeSH Terms

  • Acetabulum
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Asian Continental Ancestry Group
  • Female
  • Femur Head
  • Femur Neck
  • Hip Joint
  • Humans
  • Male
  • Middle Aged
  • Regression Analysis
  • Retrospective Studies
  • Young Adult