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FMC1 homolog (ATP synthase assembly factor FMC1, mitochondrial) (Formation of mitochondrial complex V assembly factor 1 homolog) [C7orf55] [HSPC268]


Monoclonal antibody-defined B cell subsets in aging humans and Down's syndrome.

Peripheral blood from aging and young humans and patients with Down's syndrome, and from age- and sex-matched controls, was studied for the proportions of surface immunoglobulin (SIg ) bearing and monoclonal antibodies FMC1, and FMC7 defined B lymphocytes and B lymphocyte subsets using fluorescent-activated cell sorter. In aging humans, the proportion of SIg and FMC1 (that detect all B lymphocytes) were comparable to simultaneously studied healthy young controls. However, FMC7 (that detects a subset of B cells) B cells were significantly (p less than 0.05) increased when compared to young subjects. In aging subjects, the proportions of FMC7 B cells were comparable to their FMC1 B cells, whereas in young subjects FMC7 B cells were a subset of FMC1 B cells. In Down's syndrome, a phenomenon similar to aging humans was observed, that is the proportions of FMC7 were increased when compared to age- and sex-matched controls and were comparable to their own FMC1 B cells. This study demonstrates the abnormality of B lymphocytes in human aging and Down's syndrome. The significance of these findings is discussed.

MeSH Terms

  • Adult
  • Aged
  • Aging
  • Antibodies, Monoclonal
  • B-Lymphocytes
  • Child
  • Child, Preschool
  • Down Syndrome
  • Female
  • Humans
  • Male
  • Receptors, Antigen, B-Cell
  • Reference Values