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Fibroleukin precursor (Fibrinogen-like protein 2) (pT49)


Developmental expression of B cell molecules in equine lymphoid tissues.

Identification and classification of B cell subpopulations has been shown to be challenging and inconsistent among different species. Our study tested aspects of ontogeny, phenotype, tissue distribution, and function of equine CD5 B cells, which represented a greater proportion of B cells early in development and in the peritoneal cavity. CD5 and CD5 B cells differentially expressed B cell markers (CD2, CD21, IgM) measured using flow cytometry, but similar mRNA expression of signature genes (DGKA, FGL2, PAX5, IGHM, IL10) measured using quantitative RT-PCR. Sequencing lambda light chain segments revealed that CD5 B cells generated diverse immunoglobulin repertoires, and more frequently bound to fluorescence-labeled phosphorylcholine. This study shows developmental characteristics and tissue distribution of a newly described subpopulation of B cells in the horse.

MeSH Terms

  • Aging
  • Animals
  • B-Lymphocyte Subsets
  • B-Lymphocytes
  • CD5 Antigens
  • Flow Cytometry
  • Horses
  • Immunoglobulin Light Chains
  • Immunophenotyping
  • Lymphoid Tissue
  • Phosphorylcholine


  • B cell
  • CD5
  • Development
  • Equine
  • Immunoglobulin repertoire