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Receptor tyrosine-protein kinase erbB-3 precursor (EC (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) [HER3]


[The expression of differential and matrix remodelling factors in human buccal epithelium in aging].

The expression of signaling molecules MMP2, MMP9, ERBB3, CXCL12, Nkx2.5, CD90 (the markers of remodeling intracellular matrix and cell differentiation) in human buccal epithelium in ageing has been studied. The expression of molecular markers MMP2, MMP9, CD90 end ERBB3 has shown a decrease during ageing, especially in old people compared with persons of mature age. These data have demonstrated, that buccal epithelium may be considered as a perspective object to study the aging processes in organism as a whole (on the decrease of cell for differentiation and remodeling intracellular matrix).

MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cell Differentiation
  • Epithelium
  • Female
  • Humans
  • Male
  • Matrix Metalloproteinases
  • Middle Aged
  • Mouth Mucosa