ELN
Elastin precursor (Tropoelastin)
Publications[править]
Curcumin is the major component of the yellow extract derived from the rhizome of the Curcuma longa, which is also a main bioactive polyphenol and has been generally used as a spice, food additive, and herbal medicine. In this presented study, we found that curcumin can enhance the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells via increasing ELN and FBN1 promoters' activities. With 2 μM curcumin treatment, the enhanced tropoelastin and fibrillin-1 protein amounts in Detroit 551 cells were approximately 134 and 130% of control, respectively. Therefore, our results demonstrated that curcumin may be used as a functional compound and applied to drugs, foods, and cosmetics in the future.
MeSH Terms
- Aging
- Cell Line
- Curcumin
- Elastic Tissue
- Elastin
- Fibrillin-1
- Fibrillins
- Fibroblasts
- Humans
- Microfilament Proteins
- Promoter Regions, Genetic
- RNA, Messenger
- Tropoelastin
Keywords
- curcumin
- elastin
- fibrillin-1
- fibroblast cells
- promoter activity