DEGS1
Sphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Cell migration-inducing gene 15 protein) (Degenerative spermatocyte homolog 1) (Dihydroceramide desaturase-1) (Membrane lipid desaturase) [DES1] [MLD] [MIG15]
Publications[править]
In all countries life expectancy is rising, and many older persons spend a longer period in good health. Nevertheless, frailty is present in older people and can be considered as a risk factor for limitations. The "German Health Interview and Examination Survey for Adults" (DEGS1) 2008 - 2011 comprised interviews, examinations and tests. Data on 1110 community-dwelling people aged 70 to 79 years participating in DEGS1 with full records on frailty were analysed. Physical frailty was defined as exhaustion (SF-36 item), low grip strength, slowness (Timed Up-and-Go test > 15 seconds or unable to perform) and low physical activity (no sports or exertion). In men 36,6% (CI 32,2 - 41,2) were classified as pre-frail, 2,5% (CI 1,4 - 4,4) as frail; in women 41,8% (CI 37,3 - 46,5) were classified as pre-frail, and 2,9% (CI 1,9 - 4,5) as frail. Frail persons significantly show more polypharmacy, recurrent falls, receive more frequently nursing care financial benefits, are officially recognized disabled and have poor social support. This population-based information may help to identify frail people with high risk of adverse health outcomes. Prediction models in operative anaesthesiology for specific health care settings should be developed.
MeSH Terms
- Aged
- Female
- Frail Elderly
- Frailty
- Geriatrics
- Germany
- Humans
- Male
- Prevalence
To examine cross-sectional and longitudinal associations between physical exercise and cognitive function across different age groups in a nationwide population-based sample of adults aged 18-79 years in Germany. Cross-sectional/prospective. Cognitive function was assessed in the mental health module of the German Health Interview and Examination Survey for Adults (DEGS1-MH, 2009-2012, n=3535), using a comprehensive neuropsychological test battery. Cognitive domain scores for executive function and memory were derived from confirmatory factor analysis. Regular physical exercise in the last three months was assessed by self-report and defined as no exercise, <2 and ≥2h (hours) of exercise per week. A subgroup of DEGS1-MH participants who previously participated in the German National Health Interview and Examination Survey 1998 (GNHIES98, 1997-1999, n=1624) enabled longitudinal analyses with a mean follow-up of 12.4 years. Compared to no exercise, more weekly physical exercise was associated with better executive function in cross-sectional (<2h: β=0.12; ≥2h: β=0.17; all p<0.001) and longitudinal analyses (<2h: β=0.14, p<0.001; ≥2h: β=0.15, p=0.001) using linear regression models adjusted for age, sex, education, smoking, alcohol consumption, fruit and vegetable consumption and obesity. Slightly weaker associations were found for memory in cross-sectional (<2h: β=0.08, p=0.009; ≥2h: β=0.08, p=0.026) and longitudinal analysis (<2h: β=0.09, p=0.036; ≥2h: β=0.08, p=0.114). There was no evidence of interaction between physical exercise and age. Higher levels of physical exercise were associated with better executive function and memory in cross-sectional and longitudinal analyses with no evidence for differential effects by age.
MeSH Terms
- Adolescent
- Adult
- Age Factors
- Aged
- Cognition
- Cognitive Aging
- Cross-Sectional Studies
- Executive Function
- Exercise
- Female
- Humans
- Linear Models
- Longevity
- Longitudinal Studies
- Male
- Memory
- Middle Aged
- Neuropsychological Tests
- Population Surveillance
- Prospective Studies
- Self Report
- Young Adult
Keywords
- Executive function
- Health examination survey
- Longitudinal studies
- Memory
- Neuropsychological assessment
- Risk factors