CD180
CD180 antigen precursor (Lymphocyte antigen 64) (Radioprotective 105 kDa protein) [LY64] [RP105]
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The B cell arm of adaptive immunity undergoes significant modifications with age. Elderly people are characterized by impaired B cell responses reflected in a reduced ability to effectively respond against viruses and bacteria. Alterations of immunity with advancing age (immunosenescence) have been widely studied in centenarians who are considered a good example of successful aging. In recent years, attention has shifted to centenarian offspring (CO) as a model of people genetically advantaged for healthy aging and longevity. Here, we describe the preliminary characterization of a proposed new population of memory B cells, defined as CD19( )CD38(-)CD24(-), which we find at higher frequencies in the elderly but less so in CO than healthy age-matched random controls. In addition, we found a decreased expression of RP105 (CD180), a toll-like receptor-associated molecule, on these cells. CD180 downregulation may potentially be a marker of immunosenescence. Moreover, we show that these CD19( )CD38(-)CD24(-) B cells produce TNF and hypothesize that their observed expansion in the elderly might contribute to the increased inflammatory status sometimes designated "inflamm-aging."
MeSH Terms
- ADP-ribosyl Cyclase 1
- Adult
- Aged
- Aged, 80 and over
- Aging
- B-Lymphocytes
- CD24 Antigen
- Cytokines
- Female
- Humans
- Immunity, Cellular
- Longevity
- Lymphocyte Activation
- Male
- Middle Aged
- Parents
- Reference Values
Toll-like receptors appear to play an important role in the pathogenesis of lupus-like nephritis in mice. In human and mouse, CD180 is a homologue of TLR4. In SLE patients, the number of CD180-negative B cells in peripheral blood changes in parallel with disease activity. In the present study using NZBWF1 mice, the population of splenic CD180-negative B cells increased with progression of renal lesions and aging. These cells produced both anti-dsDNA and histone antibodies; the peripheral blood levels of anti-dsDNA antibody increased markedly with aging. B cells infiltrating into renal lesions were CD180-negative and produced anti-dsDNA antibody. Considered together, these findings indicate that CD180-negative B cells contribute significantly to development of SLE-like morbidity in NZBWF1 mice by autoantibody production.
MeSH Terms
- Aging
- Animals
- Antigens, CD
- Autoantibodies
- Autoimmune Diseases
- Autoimmunity
- B-Lymphocytes
- Cells, Cultured
- Female
- Humans
- Kidney
- Lupus Nephritis
- Mice
- Mice, Inbred BALB C
- Mice, Inbred NZB
- Spleen