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Asporin precursor (Periodontal ligament-associated protein 1) (PLAP-1) [PLAP1] [SLRR1C] [UNQ215/PRO241]


The association between higher social support and lower depressive symptoms among aging services clients is attenuated at higher levels of functional impairment.

Adults seeking services from the Aging Services Provider Network (ASPN) are at risk for depression. ASPN clients also have high prevalence of both functional impairments and social morbidities. Study of the relationships between these factors may inform the development of interventions for depression in this service setting. We interviewed 373 older adults accessing ASPN services and assessed depression symptom severity, functional impairment (instrumental activities of daily living and activities of daily living), and social support. Lower social support and greater functional impairment were associated with greater depressive symptoms. At a high level of functional impairment, the inverse associations between indices of social support and depressive symptoms were attenuated. Results suggest that older adults with more severe functional impairment may benefit somewhat less from increased social support with respect to depression symptom severity.

MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Depressive Disorder
  • Disabled Persons
  • Female
  • Health Services for the Aged
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Social Support


  • aging services
  • depressive symptoms
  • functional impairment
  • social connectedness
  • social support

[Association of genetic and mechanical factors with age of onset of knee osteoarthritis].

To analyze the relationship of genetic and mechanical factors with age of onset of knee osteoarthritis (OA). Cross-sectional and longitudinal studies were conducted in 863 patients with knee OA and 999 age-matched controls from Chinese Han population with complete clinical data. Single nucleotide polymorphisms of 104T/C in rs143383 of the growth differentiation factor 5 (GDF5) gene and the aspartic acid repeat polymorphism of the asporin gene ASPN were genotyped by taqman probe and polyacrylamide gel electrophoresis respectively. Body mass index (BMI) in subjects with knee OA was significantly higher than that in controls (P< 0.01). Obesity (BMI≥ 25) was a high risk factor for knee OA (P< 0.01). Regression analysis showed that there was a certain correlation between the BMI and age of onset of the knee OA (Pearson= 0.15, P< 0.01). To analyze the BMI distribution, the two groups were subgrouped by age with 5-year interval. The BMI in early-onset patients was lower than that in the late-onset patients (F= 2.497, P= 0.011). However, there was no significant difference in the control subgroups. Frequencies of the GDF5 and ASPN alleles distributed differently between the early- and late-onset patients (P< 0.05). Genetic factors play an important role in knee osteoarthritis of early-onset patients, whereas mechanical factor play an important part in knee osteoarthritis of late-onset patients.

MeSH Terms

  • Adult
  • Age of Onset
  • Aged
  • Aging
  • Biomechanical Phenomena
  • Body Weight
  • Case-Control Studies
  • Extracellular Matrix Proteins
  • Female
  • Gene Frequency
  • Growth Differentiation Factor 5
  • Humans
  • Male
  • Mechanical Phenomena
  • Middle Aged
  • Osteoarthritis, Knee