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...[DYRK3]] promote cell survival through phosphorylation and activation of [[SIRT1]]. ...ptotic DYRK members promote cell survival through direct modification of [[SIRT1]]. These findings may have important implications in understanding the mole ...

|title=A [[SIRT1]]-centered circuitry regulates breast cancer stemness and metastasis. ...to Paclitaxel and improves therapeutic effects. Our findings delineate a [[SIRT1]]-centered circuitry that regulates CSC origination, and targeting this pat ...

|title=Endothelial [[SIRT1]] prevents adverse arterial remodeling by facilitating [[HERC2]]-mediated d ...trol.Conclusion-By downregulating acetylated LKB1 protein via [[HERC2]], [[SIRT1]] fine-tunes the crosstalk between endothelial and vascular smooth muscle c ...

...tion delays senescence and promotes proliferation of HUVECs via the AMPK/[[SIRT1]]-[[FOXA3]]-Beclin1 pathway. ...inhibit senescence, and enhance proliferation of HUVECs through the AMPK/[[SIRT1]]-[[FOXA3]]-Beclin1 pathway. ...

...e and function of EPCs through the VEGF/[[KDR]] pathway by activation of [[SIRT1]]. |keywords=* SIRT1 ...

...by the [[CCAR2]] ortholog, CCAR-1. This negative regulation requires the [[SIRT1]] homolog SIR-2.1. In addition, knockdown of CCAR-1 via ccar-1 RNAi works t ...

|title=[[SIRT1]] protects cochlear hair cell and delays age-related hearing loss via autop ...n elucidating the link between ER stress and autophagy in aging. Because [[SIRT1]] activation restores autophagy with reduced HC death and hearing loss, it ...

...cid acts on NRF2 expression, and in turn to the actions of GRα, [[GDF11]], Sirt1, and Sirt6. Regarding the increased expression of Per1, the activation effe ...

|title=Tumor suppressor [[HIC1]] directly regulates [[SIRT1]] to modulate p53-dependent DNA-damage responses. ...c silencing of [[HIC1]], we speculate that the resultant upregulation of [[SIRT1]] may be a double-edged sword that both promotes survival of aging cells an ...

.... The three down-regulated mRNA in cellular aging, [[ELK1]], [[FOS]] and [[SIRT1]], were increased with tocotrienol-rich fraction treatment. Expression of [ ...

...e and function of EPCs through the VEGF/[[KDR]] pathway by activation of [[SIRT1]]. |keywords=* SIRT1 ...

...ression of p21, PAI-1, and K382 acetylation of p53 as well as reduction of Sirt1. The knockdown of TRG5 abolished the protective role of INT-777 on these mo * Sirt1 ...

...rucial mediator in the renal aging process. Furthermore, manipulation of [[SIRT1]] activity by NMN seems to be a potential pharmaceutical intervention for A * SIRT1 ...

...iR-302b-3p inhibitor could delay skin fibroblast senescence and contribute Sirt1 expression. In addition, we demonstrated that c-Jun N-terminal kinase 2(JNK ...

...rlying mechanism remains elusive. Here, we report that Sirtinol, a known [[SIRT1]] inhibitor, induces premature senescence and growth arrest in K562 CML cel * SIRT1 ...

...ting the intracellular Sirt1-FOXO3a-[[SOD2]] axis. Moreover, the inhibited Sirt1 expression was related to the decreased mitochondrial function and the lowe ...

...erum deprivation and high confluency caused nuclear translocation of the [[SIRT1]]-regulated transcription factor FOXO3a. Our data indicate resveratrol's ac ...

|title=Dexamethasone downregulates [[SIRT1]] and [[IL6]] and upregulates [[EDN1]] genes in stem cells derived from gin ...]] was increased. Application of dexamethasone reduced the expression of [[SIRT1]] and [[IL6]] but enhanced the expression of [[EDN1]] of stem cells. ...

...s. The expression levels of Ac-histone H3, [[HDAC1]], [[HAT1]], p300 and [[SIRT1]] were increased in HT1080 cells treated with spermine. In addition, the ex * SIRT1 ...

...hylation of H3K79 (H3K79me3). Treatment of cells with either siAMPK or si[[SIRT1]] repressed [[DOT1L]]-mediated enhancement of H3K79me3. Moreover, the incre ...