TGFA
Protransforming growth factor alpha precursor [Contains: Transforming growth factor alpha (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1)]
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The objectives of the present study were to determine if adipocyte triglyceride fatty acid (TGFA) mobilization in vivo varied among the different adipose tissue depots and whether these rates were affected by age. In order to accomplish these objectives, two groups of rats were studied. The first group initially weighed 84 /- 1 and the second group 333 /- 2. Both groups were placed on a semisynthetic diet containing 6% corn oil (w/w) and 14% triundecanoin (w/w) for a period of 4 wk. Triundecanoin contains an 11-carbon (C-11) fatty acid (undecanoic acid) that was used to label the adipocyte TGFA. At the end of the 4-wk feeding period, triundecanoin was removed from the diet and replaced with an equivalent amount of corn oil. At this time and at weekly intervals for the next 4 wk, 5 rats from each age group were killed for the determination of TGFA composition in isolated adipocytes from the epididymal (Epi), perirenal (PR), subcutaneous (SC) and mesenteric (M) adipose tissue depots. When the content of C-11 was expressed as mole percent of the total fatty acids, mobilization was significantly more rapid from the PR and M depots than in the other two depots in the young rats. In the older rats mobilization was significantly slower in all depots compared to the younger group. The rates of mobilization were not different between the depots in the older animals. Since fat cell size continued to increase throughout the duration of the study, part of the decrease in C-11 content can be accounted for by dilution by newly acquired TGFA.(ABSTRACT TRUNCATED AT 250 WORDS)
MeSH Terms
- Adipose Tissue
- Aging
- Animals
- Fatty Acids
- Kinetics
- Lipid Mobilization
- Male
- Rats
- Rats, Inbred Strains
- Triglycerides