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PPARD
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Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta) [NR1C2] [PPARB] ==Publications== {{medline-entry |title=[[PPARD]] 294C overrepresentation in general and long-lived population in China Bama longevity area and unique relationships between [[PPARD]] 294T/C polymorphism and serum lipid profiles. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25873088 |abstract=The 294T/C polymorphism in the peroxisome proliferator-activated receptor delta ([[PPARD]]) gene is associated with hyperlipidemia in several younger populations, but results are still inconsistence across ethnic groups and its possible impact on the lipid profiles of long-lived individuals remains unexploited. Here, we aimed to evaluate the possible correlation between [[PPARD]] 294T/C and serum lipid levels in a long-lived population in Bama, a region known for longevity situated in Guangxi, China. Genotyping of [[PPARD]] 294T/C polymorphism was conducted in 505 long-lived inhabitants (aged 90 and above, long-lived group, LG) and 468 healthy controls (aged 60-75, non-long-lived group, non-LG) recruited from Bama area. No difference in allelic and genotypic frequencies was found between the two groups (P>0.05). However, C-allele and C-genotype (TC and CC) were significantly more frequent in the females of non-LG than were LG after sex stratification. CC carriers exhibited higher LDL-C level in LG (P<0.05) but lower TC, [[TG]] and LDL-C in non-LG (P<0.05 for each) than TT carriers; C allele carriers (TC/CC) in LG exhibited higher TC, [[TG]], and LDL-C levels as compared with the same genotype and the same lipid parameter in non-LG (P<0.05 for each). LDL-C in LG was correlated with genotypes while TC, [[TG]], and LDL-C in non-LG were correlated with genotypes (P<0.05-0.001). Our results suggest that there were different impact patterns of [[PPARD]] 294T/C polymorphism on lipid profiles between long-lived cohort and average population in Bama area and this may be one of the genetic bases of its longevity. |mesh-terms=* Aged * Aged, 80 and over * Asian Continental Ancestry Group * Case-Control Studies * China * Cholesterol * Cholesterol, HDL * Cholesterol, LDL * Female * Genetic Association Studies * Humans * Lipids * Longevity * Male * Middle Aged * PPAR delta * Polymorphism, Single Nucleotide * Triglycerides |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356147 }} {{medline-entry |title=[Genotype and allele frequencies of UCP and PPAR gene families in residents of besieged Leningrad and in the control group]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25826986 |abstract=Genotype and allele frequencies of uncoupling proteins 2 and 3 genes ([[UCP2]] and [[UCP3]]) and peroxisome proliferator-activated receptors genes ([[PPARA]], [[PPARD]] and [[PPARG]]) were studied in 206 residents of the siege and in 139 individuals of more than 69 years old (control group). Studied polymorphisms included [[UCP2]] (Ala55Val), [[UCP3]] (C-55T), [[PPARA]] (G/C), [[PPARD]] ( 294T/C), and [[PPARG]] (Pro12Ala). The G allele and the G/G genotype ([[PPARA]]) were overrepresented in the group of survivors and C/C ([[UCP3]]) genotype prevailed in the women of besieged Leningrad compared to relevant control groups of the persons of the same age who did not suffered hungry disaster. Feasible protective effects of [[PPARA]] gene allele G and C allele of [[UCP2]] genes are briefly discussed. |mesh-terms=* Aged * Aged, 80 and over * Case-Control Studies * Cities * Data Interpretation, Statistical * Female * Gene Frequency * Genotype * Humans * Ion Channels * Longevity * Male * Malnutrition * Mitochondrial Proteins * PPAR alpha * PPAR delta * PPAR gamma * Polymorphism, Single Nucleotide * Russia * Survivors * Uncoupling Protein 2 * Uncoupling Protein 3 * World War II }}
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