MED28

Материал из hpluswiki
Версия от 22:30, 29 апреля 2021; OdysseusBot (обсуждение | вклад) (Новая страница: «Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal pro...»)
(разн.) ← Предыдущая версия | Текущая версия (разн.) | Следующая версия → (разн.)
Перейти к навигации Перейти к поиску

Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1) [EG1] [FKSG20]

Publications[править]

Redox regulation of the MED28 and MED32 mediator subunits is important for development and senescence.

Mediator is a conserved multi-protein complex that acts as a bridge between promoter-bound transcriptional regulators and RNA polymerase II. While redox signaling is important in adjusting plant metabolism and development, the involvement of Mediator in redox homeostasis and regulation only recently started to emerge. Our previous results show that the MED10a, MED28, and MED32 Mediator subunits form various types of covalent oligomers linked by intermolecular disulfide bonds in vitro. To link that with biological significance we have characterized Arabidopsis med32 and med28 mutants and found that they are affected in root development and senescence, phenotypes possibly associated to redox changes.

MeSH Terms

  • Arabidopsis
  • Arabidopsis Proteins
  • Gene Expression Regulation, Plant
  • Hydrogen Peroxide
  • Mediator Complex
  • Mutation
  • Oxidation-Reduction
  • Plant Roots

Keywords

  • Mediator
  • Oligomerization
  • Redox
  • Root development
  • Senescence