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==Publications== {{medline-entry |title=Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29603369 |abstract=Patients with inflammatory bowel disease (IBD) are at a high risk of low bone mineral density (BMD). Reportedly, clinical and genetic factors cause low BMD in Caucasians; however, studies in non-Caucasian populations remain scarce. Clinical risk factors for low BMD were investigated in 266 Japanese patients with IBD, and a genome-wide association analysis (GWAS) was performed using linear regression with associated clinical factors as covariates. Genotyping was performed using a population-optimized genotyping array (Japonica array ). After quality control, the genotype data of 4 384 682 single-nucleotide polymorphisms (SNPs) from 254 patients with IBD were used for GWAS. Body mass index, age, and disease duration were independently associated with the BMD of the femoral neck (P = 1.41E - 13, 1.04E - 5, and 1.58E - 3, respectively), and body mass index and sex were associated with the BMD of the lumbar spine (P = 6.90E - 10 and 6.84E - 3, respectively). In GWAS, 118 and 42 candidate SNPs of the femoral neck and lumbar spine, respectively, were identified. Among 118, 111 candidate SNPs of the femoral neck were located within the [[SLC22A23]] gene, which is a known IBD susceptibility gene (minimum P = 1.42E - 07). Among 42, 18 candidate SNPs of the lumbar spine were located within the [[MECOM]] gene, which is associated with osteopenia (minimum P = 5.86E - 07). Interestingly, none of the known loci showed a significant association with BMD. Although clinical risk factors for low BMD in IBD were similar to those in the general population, genetic risk factors were rather different. |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Asian Continental Ancestry Group * Body Mass Index * Bone Density * Bone Diseases, Metabolic * Female * Femur Neck * Genetic Predisposition to Disease * Genome-Wide Association Study * Genotype * Humans * Inflammatory Bowel Diseases * Lumbar Vertebrae * MDS1 and EVI1 Complex Locus Protein * Male * Middle Aged * Organic Anion Transporters * Polymorphism, Single Nucleotide * Risk Factors * Sex Characteristics * Young Adult |keywords=* genome-wide association analysis * inflammatory bowel disease genetics * osteoporosis |full-text-url=https://sci-hub.do/10.1111/jgh.14149 }}
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