ELN

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Elastin precursor (Tropoelastin)

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Curcumin enhances the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells.

Curcumin is the major component of the yellow extract derived from the rhizome of the Curcuma longa, which is also a main bioactive polyphenol and has been generally used as a spice, food additive, and herbal medicine. In this presented study, we found that curcumin can enhance the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells via increasing ELN and FBN1 promoters' activities. With 2 μM curcumin treatment, the enhanced tropoelastin and fibrillin-1 protein amounts in Detroit 551 cells were approximately 134 and 130% of control, respectively. Therefore, our results demonstrated that curcumin may be used as a functional compound and applied to drugs, foods, and cosmetics in the future.

MeSH Terms

  • Aging
  • Cell Line
  • Curcumin
  • Elastic Tissue
  • Elastin
  • Fibrillin-1
  • Fibrillins
  • Fibroblasts
  • Humans
  • Microfilament Proteins
  • Promoter Regions, Genetic
  • RNA, Messenger
  • Tropoelastin

Keywords

  • curcumin
  • elastin
  • fibrillin-1
  • fibroblast cells
  • promoter activity