CFI
Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain] [IF]
Publications[править]
We explored possible paths from physical and mental health-related quality of life, self-efficacy, optimism, and social support to happiness in older adults, considering hedonic balance and life satisfaction as mediators. A total of 154 Spanish male and female (50%) older adults (65-96 years old, M = 77.44, SD = 8.03; 64% noninstitutionalized elderly) voluntarily participated in this correlational, cross-sectional study. The participants completed self-reports on their perceived health status, self-efficacy, social support, optimism, and global subjective well-being (SWB) as well as its dimensions. Path analysis was used to examine direct and indirect relationships. The final model had an excellent fit with the data (χ2(10) = 11.837, [i]p[/i] = 0.296, χ2/df = 1.184; SRMR = 0.050, CFI = 0.994, RMSEA = 0.035), revealing the unique causal effects of all the included predictors on happiness. With the exception of self-efficacy, the psychosocial resources predicted older adults' current happiness, and this relationship was fully mediated by hedonic balance and life satisfaction, which were found to be putative intermediary factors for SWB. Self-efficacy in turn predicted the remaining psychosocial resources. Our findings extend the existing evidence on the influences of health-related quality of life, self-efficacy, optimism, and social support on SWB. Furthermore, they support the proposal of hedonic balance and life satisfaction as dimensions of SWB, thus supporting the tripartite hierarchical model of happiness. These results may inform future interventions seeking to improve happiness in late adulthood.
MeSH Terms
- Adult
- Aged
- Aged, 80 and over
- Aging
- Cross-Sectional Studies
- Female
- Happiness
- Health Status
- Humans
- Male
- Personal Satisfaction
- Quality of Life
Keywords
- happiness
- older adults
- path analysis
- psychosocial resources
- subjective well-being
Flourishing is related to positive outcomes for physical and mental health, as well as overall wellbeing. The aim of the present study was to determine the validity and reliability of the Flourishing Scale (FS) among a sample of older participants in Iran. In this validation study, 300 older people were selected by cluster sampling method. Data were collected using a checklist for demographic characteristics, the FS, and the Oxford happiness questionnaire. The validity (face, content, convergent, and construct) and reliability (Cronbach's alpha, test-retest) of the FS was evaluated in this cross-sectional study. The exploratory factor analysis demonstrated a one-dimensional structure consisting of 8 items with an eigenvalue of 3.583. The model had a good fit [χ = 52.983, p < 0.001, χ /df = 2.944, GFI = 0.958, CFI = 0.915, IFI = 0.949, TLI = 0.919, AGFI = 0.948, and RMSEA = 0.081, SRMR = 0.086] with all factor loadings greater than 0.5 and statistically significant. A test of concurrent validity showed a direct and significant association between the FS and the Oxford happiness questionnaire ([i]r[/i] = 0.647, [i]p[/i] < 0.001). The results of the reliability tests confirmed that the values of Cronbach's alpha coefficient (0.819) and test-retest (0.821) were acceptable. The Persian version of the FS demonstrated suitable validity and reliability among a sample of older participants.
MeSH Terms
- Aged
- Aging
- Cross-Sectional Studies
- Female
- Geriatric Assessment
- Health Status Disparities
- Humans
- Iran
- Male
- Mental Health
- Psychometrics
- Reproducibility of Results
- Surveys and Questionnaires
Keywords
- aging
- factor analysis
- flourishing
- reliability
- validity
New reliable and valid instrument to describe health professionals representations about retirement.A valid instrument that can be used to compare different health professionals.Job satisfaction is the major factor associated with positions about general policies about retirement. To test the psychometric properties of a newly designed instrument to describe the REpresentations and Practices About REtirement (the PREPARE instrument). Participants were nurses and doctors working in the two public hospitals of Porto, aged 55-65 years, in 2011. Among the 367 eligible participants, 231 (65.9%) participated in the study. The PREPARE instrument consists of four sections: 9, 5 and 12, respectively. A principal component analysis was performed to evaluate the scale's dimensionality, followed by a confirmatory factor analysis to test the fit using different indexes (TLI - Tucker-Lewis Index and CFI - Confirmatory fit index). Principal confirmatory analysis and confirmatory factor analysis identified 3, 1 and 2 factors for section 1, 2 and 3. All confirmatory factor analysis models had a value of CFI and TLI higher than 0.9. Section 1 showed a first factor related with items about the importance of personal competences, a second factor related with items about the importance of relationships with patients, and third factor related with items about the importance of following ethical and directive rules; section 2 showed a general factor about the features you valued most in the other health professional group; and, finally, in section 3, the first factor was related with items about satisfaction with the work environment and the second factor with items about satisfaction with professional career. The PREPARE instrument has the basic requirements of a valid and reliable measurement of a scale to describe medical doctors and nurses representations and practices about the decision regarding retirement.
Keywords
- Aging
- Job satisfaction
- Retirement
- Scale
This study tested the extent to which the emotional climate (positive and negative relationship quality) in family relationships and intimate partnerships are each uniquely linked to specific domains of aging health outcomes, over and above the impact of earlier health. Data included partnered participants who completed all three waves of the Midlife Development in the United States (MIDUS). We used measures of family and intimate partner strain and support, at MIDUS 1, 2, and 3, and estimated the effects of each on subsequent morbidity and health appraisal (i.e., 10 and 20 years later). Autoregressive cross-lagged paths were modeled using maximum likelihood estimation with robust standard errors. Family strain was associated with later health in both the morbidity, χ²(35) = 411.01, [i]p[/i] < .001; root mean square error of approximation (RMSEA) = .062, comparative fit index (CFI) = .952; standardized root-mean-square residual (SRMR) = .034 and health appraisal, χ²(35) = 376.80, [i]p[/i] < .001; RMSEA = .058, CFI = .956; SRMR = .032 models. Morbidity and health appraisal also predicted later family emotional climate, reciprocally. Intimate partner emotional climate-health pathways were nonsignificant at each wave, in both models. Results are novel and may be the first to indicate the quality of family relationships are a more powerful predictor of aging health than the quality of intimate partnerships. Findings implicate the health of adults should be considered in the systemic context of families. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
MeSH Terms
- Adult
- Aged
- Aging
- Emotions
- Family Relations
- Female
- Health Status
- Humans
- Interpersonal Relations
- Longitudinal Studies
- Male
- Middle Aged
- Sexual Partners
- United States
This study aims to adapt and validate the most common measure of self-esteem, the Rosenberg Self-Esteem Scale (RSES), in the elderly Spanish population based on the initial one-factor model proposed by the author of the scale. The factorial validity of the scale was tested using confirmatory factor analysis. The study was carried out in the city of Valencia (Spain). A total of 231 elderly people with a mean age 72.68 (SD=8.55). The participants completed the questionnaire RSES for the validation process, sociodemographic data and Mini-Mental State Examination. Confirmatory factor analysis with a five-item structure for the one-factor structure showed good fit indexes (Chi square [5] = 217.20, p < .05; CFI = .965; GFI = .980; RMSEA = .070 [90% confidence interval of RMSEA, .022-.087]), and reliability, as internal consistency, measure with Cronbach's alpha was .732. The adaptation of the RSES showed a unifactorial structure with good internal consistency. This reduced adaptation/version of the scale may facilitate clinical practice and be useful in research in older people.
Keywords
- aging
- life span
- self-esteem
- structural equation model
- validity
We examined the multidimensionality of the new Perceived Ability to Prevent and Manage Fall Risks (PAPMFR) scale that assesses fall-related efficacy (FE) and the mediating role of EF between fear of falling (FOF) and functional mobility (FM). We carried out a secondary data analysis of 552 participants (mean age = 76.45, SD = 7.79) in a fall prevention program, A Matter of Balance Volunteer Lay Leader Model (AMOB/VLL). We used exploratory and confirmatory factor analyses to evaluate the PAPMFR scale. We used structural equation modeling to test the mediating role of PAPMFR between FOF and FM. We identified 3 dimensions of PAPMFR: steadiness/balance, gait, and fall management. We confirmed the mediating effect of the PAPMFR on the relation between FOF and FM with acceptable fit in cross-sectional (χ²/df = 2.25, RMSEA = .06, 95% CI: .04 to .09, CFI = .98 SRMR = .03) and half-longitudinal (χ²/df = 3.04, RMSEA = .08, 95% CI: .07 to .09, CFI = .95, SRMR = .04) models. AMOB/VLL shows promise to enhance FE, which may mediate FM improvements among participants. Find- ings suggest that improving confidence to prevent and manage falls can complement exercise training to promote active aging. Future research should investigate various FE dimensions.
MeSH Terms
- Accidental Falls
- Aged
- Aged, 80 and over
- Aging
- Female
- Gait
- Humans
- Male
- Patient Education as Topic
- Postural Balance
- Psychometrics
- Self Efficacy
Recommended cut-off criteria for testing measurement invariance (MI) using the comparative fit index (CFI) vary between -0.002 and -0.01. We compared CFI results with those obtained using Bayesian approximate MI for cognitive function. We used cognitive function data from Waves 1-5 of the English Longitudinal Study of Ageing (ELSA; Wave 1 n = 11,951), a nationally representative sample of English adults aged ≥50. We tested for longitudinal invariance using CFI and approximate MI (prior for a difference between intercepts/loadings ~N(0,0.01)) in an attention factor (orientation to date, day, week, and month) and a memory factor (immediate and delayed recall, verbal fluency, and a prospective memory task). Conventional CFI criteria found strong invariance for the attention factor (CFI 0.002) but either weak or strong invariance for the memory factor (CFI -0.004). The approximate MI results also supported strong MI for attention but found 9/20 intercepts or thresholds were noninvariant for the memory factor. This supports weak rather than strong invariance. Within ELSA, the attention factor is suitable for longitudinal analysis but not the memory factor. More generally, in situations where the appropriate CFI criteria for invariance are unclear, Bayesian approximate MI could alternatively be used.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Attention
- Bayes Theorem
- Cognition
- Data Interpretation, Statistical
- England
- Female
- Humans
- Longitudinal Studies
- Male
- Memory
- Middle Aged
Keywords
- ELSA
- approximate measurement invariance
- cognitive function
- old age
- statistics
The study aimed to investigate psychometric indicators of validity in the new version of CASP-19 for Brazilians 55 years and older and to study relations between scores on the scale and sex, age, schooling, and conjugal status. A total of 368 participants enrolled in educational programs for the elderly answered the CASP-19 scale (control, autonomy, self-realization, and pleasure), translated from English by five specialists and tested in 19 women (α = 0.730). The data were submitted to exploratory factors analyses (EFA) and confirmatory factor analyses (CFA) using the structural equations method for latent variables and for internal consistency and correlation with scales of similar content. The scores were compared according to sex, age, schooling, and conjugal status. CFA produced a model with 19 items and 2 factors (self-realization/pleasure and control/autonomy), with good fit indices (GFI = 0.8; AGFI = 0.7606; CFI = 0.7241; NNFI = 0.6876; SRMR = 0.0902; RMSEA = 0.0928; 90%CI: 0.0827-0.1031). Cronbach's α was 0.837 for factor 1 and 0.670 for factor 2, and 0.874 on the total scale for individuals with 9 or more years of schooling, 0.834 for 5 to 8 years, and 0.772 for 1 to 4 years. High and significant correlations were observed with the scores in scales on satisfaction and subjective happiness. Men scored higher than women on self-realization/pleasure; older individuals and those with the most schooling scored lower on control/autonomy; individuals with a spouse or partner scored higher on control/autonomy. The new version of CASP-19 was effective in assessing self-rated quality of life in individuals 55 years or older in residents of the Southeast, South, and Northeast of Brazil.
MeSH Terms
- Achievement
- Aged
- Aging
- Brazil
- Cross-Cultural Comparison
- Educational Status
- Female
- Humans
- Male
- Middle Aged
- Personal Autonomy
- Personal Satisfaction
- Psychometrics
- Quality of Life
- Semantics
- Surveys and Questionnaires
- Translations
The Mental Health Index (MHI) is widely used as a measure of mental health status, but has not been evaluated in the geriatric oncology population. This study evaluated the MHI-17 in a geriatric oncology population, to establish validity and scoring rules. The Carolina Senior Registry (NCT01137825) was used to obtain data for 686 patients with cancer 65 and older who completed the MHI-17. The 17-item patient-reported measure produces one total score summing across four domains: anxiety, depression, positive affect, and sense of belonging. Cronbach's alpha (α), confirmatory factor analyses (CFA), item-response theory (IRT) analyses, and differential item functioning (DIF) analyses were used to evaluate internal consistency and validity. The revised MHI retained the 13 best-fitting items from the MHI-17 and resulted in a final model that included two subscales: anxiety (four items, RMSEA 0.11; CFI 0.99; TLI 0.98) and depression (9 items, RMSEA 0.10; CFI 0.96; TL 0.95). IRT analyses of the four anxiety items indicated good fit (RMSEA 0.08) and precise measurement of adults with poor mental health, and the nine depression items also fit well (RMSEA 0.05). No meaningful differences were found by sex, education, or treatment stage. Scores were developed to provide meaningful norms. The new MHI-13 is a shorter, more accurate way to assess mental health in older adults with cancer and most importantly allows clinicians to separately identify anxiety and/or depression - a clinically important distinction as treatment differs among these two types of mental health impairment.
MeSH Terms
- Affect
- Aged
- Aged, 80 and over
- Anxiety
- Depression
- Factor Analysis, Statistical
- Female
- Geriatrics
- Humans
- Male
- Medical Oncology
- Mental Health
- Neoplasms
- Psychological Distance
- Psychological Distress
- Psychometrics
- Registries
- Reproducibility of Results
- Retrospective Studies
- Surveys and Questionnaires
Keywords
- Geriatric assessment
- Geriatric oncology
- Mental health
- Psychometric validation
- Reliability
- Validity
Background/Study Context: Conceptual frameworks are analytic models at a high level of abstraction. Their operationalization can inform randomized trial design and sample size considerations. The Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) conceptual framework was empirically tested using structural equation modeling (N=2,802). ACTIVE was guided by a conceptual framework for cognitive training in which proximal cognitive abilities (memory, inductive reasoning, speed of processing) mediate treatment-related improvement in primary outcomes (everyday problem-solving, difficulty with activities of daily living, everyday speed, driving difficulty), which in turn lead to improved secondary outcomes (health-related quality of life, health service utilization, mobility). Measurement models for each proximal, primary, and secondary outcome were developed and tested using baseline data. Each construct was then combined in one model to evaluate fit (RMSEA, CFI, normalized residuals of each indicator). To expand the conceptual model and potentially inform future trials, evidence of modification of structural model parameters was evaluated by age, years of education, sex, race, and self-rated health status. Preconceived measurement models for memory, reasoning, speed of processing, everyday problem-solving, instrumental activities of daily living (IADL) difficulty, everyday speed, driving difficulty, and health-related quality of life each fit well to the data (all RMSEA < .05; all CFI > .95). Fit of the full model was excellent (RMSEA = .038; CFI = .924). In contrast with previous findings from ACTIVE regarding who benefits from training, interaction testing revealed associations between proximal abilities and primary outcomes are stronger on average by nonwhite race, worse health, older age, and less education (p < .005). Empirical data confirm the hypothesized ACTIVE conceptual model. Findings suggest that the types of people who show intervention effects on cognitive performance potentially may be different from those with the greatest chance of transfer to real-world activities.
MeSH Terms
- Activities of Daily Living
- Aged
- Aged, 80 and over
- Aging
- Cognition Disorders
- Female
- Geriatric Assessment
- Health Education
- Health Status
- Humans
- Male
- Memory Disorders
- Models, Psychological
- Problem Solving
- Quality of Life
- Research Design
Subjective cognitive complaint is a sensitive marker of decline. This study aimed to (1) examine reliability of subjective cognitive complaint using the Cognitive Function Instrument (CFI), and (2) assess the utility of the CFI to detect cognitive decline in non-demented elders. Data from a four-year longitudinal study at multiple Alzheimer's Disease Cooperative Study (ADCS) sites were extracted (n = 644). Of these, 497 had Clinical Dementia Rating (CDR) global scores of 0 and 147 had a CDR of 0.5. Mean age and education were 79.5±3.6 and 15.0±3.1 years, respectively. All participants and their study partners completed the subject and study partner CFI yearly. Modified Mini-Mental State Exam (mMMSE) and Free and Cued Selective Reminding Test (FCSRT) were administered. Scores below the predetermined cut-off scores on either measure at annual visit were triggers for a full diagnostic evaluation. Cognitive decline was defined by the absence/presence of the trigger. Three-month test retest reliability showed that inter-class coefficients for subject and study partner CFI were 0.76 and 0.78, respectively. Generalized estimating equation method revealed that both subject and study partner CFI change scores and scores from previous year were sensitive to cognitive decline in the CDR 0 group (p < 0.05). In the CDR 0.5 group, only the study partner CFI change score predicted cognitive decline (p < 0.05). Cognitive decline was predicted differentially by CDR level with subject CFI scores providing the best prediction for those with CDR 0 while study partner CFI predicted best for those at CDR 0.5.
MeSH Terms
- Aged
- Aged, 80 and over
- Aging
- Cognition
- Cognitive Dysfunction
- Female
- Humans
- Male
- Mental Status and Dementia Tests
- Neuropsychological Tests
- Reproducibility of Results
- Surveys and Questionnaires
Keywords
- Cognitive decline
- healthy older adults
- non-demented elders
- subjective cognitive complaints
To compare the effect of elevated intraocular pressure (IOP) on retinal capillary filling in elderly vs adult rats using optical coherence tomography angiography (OCTA). The IOP of elderly (24-month-old, N=12) and adult (6-8month-old, N=10) Brown Norway rats was elevated in 10mmHg increments from 10 to 100mmHg. At each IOP level, 3D OCT data were captured using an optical microangiography (OMAG) scanning protocol and then post-processed to obtain both structural and vascular images. Mean arterial blood pressure (MAP), respiratory rate, pulse and blood oxygen saturation were monitored non-invasively throughout each experiment. Ocular perfusion pressure (OPP) was calculated as the difference between MAP for each animal and IOP at each level. The capillary filling index (CFI), defined as the ratio of area occupied by functional capillary vessels to the total scan area but excluding relatively large vessels of >30μm, was calculated at each IOP level and analyzed using the OCTA angiograms. Relative CFI vs IOP was plotted for the group means. CFI vs OPP was plotted for every animal in each group and data from all animals were combined in a CFI vs OPP scatter plot comparing the two groups. The MAP in adult animals was 108±5mmHg (mean±SD), whereas this value in the elderly was 99±5mmHg. All other physiologic parameters for both age groups were uniform and stable. In elderly animals, significant reduction of the CFI was first noted at IOP 40mmHg, as opposed to 60mmHg in adult animals. Individual assessment of CFI as a function of OPP for adult animals revealed a consistent plateau until OPP reached between 40 and 60mmHg. Elderly individuals demonstrated greater variability, with many showing a beginning of gradual deterioration of CFI at an OPP as high as 80mmHg. Overall comparison of CFI vs OPP between the two groups was not statistically significant. Compared to adults, some, but not all, elderly animals demonstrate a more rapid deterioration of CFI vs OPP. This suggests a reduced autoregulatory capacity that may contribute to increased glaucoma susceptibility in some older individuals. This variability must be considered when studying the relationship between IOP, ocular perfusion and glaucoma in elderly animal models.
MeSH Terms
- Age Factors
- Aging
- Animals
- Capillaries
- Disease Models, Animal
- Homeostasis
- Image Interpretation, Computer-Assisted
- Imaging, Three-Dimensional
- Intraocular Pressure
- Ocular Hypertension
- Predictive Value of Tests
- Rats, Inbred BN
- Regional Blood Flow
- Retinal Vessels
- Tomography, Optical Coherence
Keywords
- Intra-ocular pressure
- Ocular perfusion pressure
- Optical coherence tomography
- Optical microangiography
- Retinal capillary blood flow
The aim of this study was to test a conceptual model designed to promote the understanding of factors influencing subjective well-being (SWB) in old age. Within this framework, we evaluated the relative influences on elderly Israelis' SWB of health and/or function, personal resources, coping behaviors (reactive and proactive), and changes in all of these factors over time. At baseline, 1216 randomly selected elderly persons (75 ) were interviewed at home (T1) and 1019 one year later (T2). The conceptual model was evaluated by Structural Equation Modeling (SEM) analysis using AMOS 18. After one year, a relatively high percentage of participants reported decline in health/function (DHF) and in personal resources. The effects of the study variables on T2-SWB were evaluated by a SEM analysis, resulting in a satisfying fit: χ = 279.5 (df = 102), p < .001, CFI = .970, NFI = .954, TLI = .955, RMSEA = .046. In addition to significant direct effects of health/function on T2-SWB, health/function was found to indirectly influence T2-SWB. Our analysis showed that health/function had a negative influence on the positive effects of personal resources (function self-efficacy, social support) and the diverse effects of the coping patterns (goal-reengagement - positive; expectations for future care needs - negative; having concrete plans for future care - positive). Personal resources and use of appropriate coping behaviors enable elderly people to control their well-being even in the presence of DHF. Evidence-based interventions can help older people to acquire and/or strengthen effective personal resources and coping patterns, thus, promoting their SWB.
MeSH Terms
- Adaptation, Psychological
- Aged
- Aged, 80 and over
- Aging
- Female
- Geriatric Assessment
- Humans
- Israel
- Longitudinal Studies
- Male
- Personal Satisfaction
- Quality of Life
- Resilience, Psychological
- Self Efficacy
- Social Support
Keywords
- Subjective well-being
- health
- personal resources
- proactive coping
- reactive coping
The optimal age to cryopreserve oocytes for later use is before 36 years. Current users are on average 38 years old. In this cross-sectional study an online survey was constructed about the factors associated with the intentions of childless women aged 28-35 years to use fertility preservation (FP). Questions were derived from the Theory of Planned Behaviour (attitudes and subjective norms regarding FP and perceived behaviour control to do FP) and the Health Belief Model (perceived susceptibility of infertility, perceived severity of childlessness, barriers and benefits of FP and cue to use FP). Also addressed were parenthood goals, fertility knowledge and intentions to use FP within 2 years. The data were analysed using structural equation modelling. The Health Belief Model showed a good fit to the data (χ(2) [14, n = 257] = 13.63, P = 0.477; CFI = 1.000: RMSEA = 00, 90% CI [0.00-0.06]). Higher intentions to use FP were associated with feeling susceptible to infertility, considering FP useful to achieve parenthood, perceiving the implications of infertility as severe, expecting to have children at a later age and having fewer ethical concerns. This suggests an increase of fertility awareness is necessary for the optimal use of FP.
MeSH Terms
- Adult
- Aging
- Cross-Sectional Studies
- Decision Making
- Female
- Fertility Preservation
- Health Knowledge, Attitudes, Practice
- Humans
- Infertility, Female
- Intention
- Perception
- Pregnancy
Keywords
- cryopreservation
- fertility
- health behaviour
- oocytes
- psychology
{{medline-entry |title=Factorial Structure and Measurement Invariance of the PANAS in Spanish Older Adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26054863 |abstract=Developmental theories suggest age-related changes in the structure of affect. Paradoxically, the internal structure of the Positive and Negative Affect Schedule (PANAS; Watson, Clark,