Материал из hpluswiki
Версия от 18:06, 12 мая 2021; OdysseusBot (обсуждение | вклад) (Новая страница: «C2 domain-containing protein 2 (Transmembrane protein 24-like) [C21orf25] [C21orf258] [TMEM24L] ==Publications== {{medline-entry |title=Genetic variants associa...»)
(разн.) ← Предыдущая версия | Текущая версия (разн.) | Следующая версия → (разн.)
Перейти к навигации Перейти к поиску

C2 domain-containing protein 2 (Transmembrane protein 24-like) [C21orf25] [C21orf258] [TMEM24L]


Genetic variants associated with physical performance and anthropometry in old age: a genome-wide association study in the ilSIRENTE cohort.

Unraveling the complexity of aging is crucial for understanding its mechanisms and its role as a risk factor for most chronic conditions. Advancements marked by genome-wide association studies (GWASs) have sparked interest in gene cataloguing in the context of aging and age-related conditions. Here, we used GWAS to explore whether single nucleotide polymorphisms (SNPs) were associated with functional and anthropometric parameters in a cohort of old community-dwellers enrolled in the ilSIRENTE study. Analyses were carried out in men and women aged 80 years enrolled in the ilSIRENTE study (n = 286) and replicated in the inCHIANTI study (n = 1055). Genotyping was accomplished on Infinium Human610-QUAD version 1. In the ilSIRENTE population, genetic variants in ZNF295 and C2CD2 (rs928874 and rs1788355) on chromosome 21q22.3, were significantly associated with the 4-meter gait speed (rs928874, p = 5.61 × 10 ; rs1788355, p = 5.73 × 10 ). This association was not replicated in the inCHIANTI population. Our findings suggest that specific SNPs may be associated with a key measure of physical performance in older adults. GWASs using larger samples are needed to confirm these preliminary results to enhance our comprehension of complex age-associated phenomena.

MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Anthropometry
  • DNA-Binding Proteins
  • Female
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Male
  • Membrane Proteins
  • Physical Functional Performance
  • Polymorphism, Single Nucleotide
  • Transcription Factors
  • Walking Speed