Aging genes 30-39

CCL2[править]

Assessment of neuroinflammation in the aging hippocampus using large-molecule microdialysis: Sex differences and role of purinergic receptors. / 07.11.2020 / PubMed / Full text
Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients. / 01.2021 / PubMed / Full text
IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2. / 25.10.2020 / PubMed / Full text
Eosinophils and White Fat: Protection from Worms and Inflammaging. / 08.2020 / PubMed / Full text
CXCL9 and CXCL10 display an age-dependent profile in Chagas patients: a cohort study of aging in Bambui, Brazil. / 11.05.2020 / PubMed / Full text
p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to non-nucleoside reverse transcriptase inhibitors. / 06.2020 / PubMed / Full text
β1 Integrin regulates adult lung alveolar epithelial cell inflammation. / 30.01.2020 / PubMed / Full text
Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging. / 01.2020 / PubMed / Full text
Klotho-mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments. / 11.2019 / PubMed / Full text
Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. / 07.2019 / PubMed / Full text
Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA accompanied with pro-tumorigenic secretome. / 01.08.2019 / PubMed / Full text
Isoflurane anesthesia impairs the expression of immune neuromodulators in the hippocampus of aged mice. / 2018 / PubMed / Full text
Melatonin and inflammation-Story of a double-edged blade. / 11.2018 / PubMed / Full text
Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis. / 2018 / PubMed / Full text
Urine Cytokine and Chemokine Levels Predict Urinary Tract Infection Severity Independent of Uropathogen, Urine Bacterial Burden, Host Genetics, and Host Age. / 09.2018 / PubMed / Full text
Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice. / 07.2018 / PubMed / Full text
Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. / 05.2018 / PubMed / Full text
Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. / 2018 / PubMed / Full text
Immune senescence and biomarkers profile of Bambuí aged population-based cohort. / 03.2018 / PubMed / Full text
Selected life-extending interventions reduce arterial CXCL10 and macrophage colony-stimulating factor in aged mouse arteries. / 08.2017 / PubMed / Full text
Strain specificities in cellular and molecular immunopathogenic mechanisms underlying development of experimental autoimmune encephalomyelitis in aged rats. / 06.2017 / PubMed / Full text
Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension. / 02.2017 / PubMed / Full text
An attenuated immune response by Schwann cells and macrophages inhibits nerve regeneration in aged rats. / 09.2016 / PubMed / Full text
Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging. / 04.2016 / PubMed / Full text
Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling. / 02.2016 / PubMed / Full text
Alterations in Monocyte Phenotypes and Functions after a Hip Fracture in Elderly Individuals: A 6-Month Longitudinal Study. / 2016 / PubMed / Full text
Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1-Infected Men. / 01.03.2016 / PubMed / Full text
APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. / 07.10.2015 / PubMed / Full text
Colorectal cancer-promoting activity of the senescent peritoneal mesothelium. / 06.10.2015 / PubMed / Full text
Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer's disease models. / 24.09.2015 / PubMed / Full text
Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age. / 2015 / PubMed / Full text
Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice. / 2015 / PubMed / Full text
CCL2, CXCL8, CXCL9 and CXCL10 serum levels increase with age but are not altered by treatment with hydroxychloroquine in patients with osteoarthritis of the knees. / 12.2017 / PubMed / Full text
Senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis. / 07.2015 / PubMed / Full text
Age-associated changes in basal NF-κB function in human CD4 T lymphocytes via dysregulation of PI3 kinase. / 11.2014 / PubMed / Full text
IL-4 signaling drives a unique arginase /IL-1β microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Rα after traumatic spinal cord injury. / 25.06.2014 / PubMed / Full text
Systemic inflammation impairs attention and cognitive flexibility but not associative learning in aged rats: possible implications for delirium. / 2014 / PubMed / Full text
Impaired innate mucosal immunity in aged mice permits prolonged Streptococcus pneumoniae colonization. / 12.2013 / PubMed / Full text
Effects of ethanol on immune response in the brain: region-specific changes in adolescent versus adult mice. / 02.2014 / PubMed / Full text

CD14[править]

Human innate immune cell crosstalk induces melanoma cell senescence. / 30.08.2020 / PubMed / Full text
Lipopolysaccharide binding protein is associated with CVD risk in older adults. / 08.09.2020 / PubMed / Full text
Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors-A Possible Involvement of DC-STAMP. / 02.09.2020 / PubMed / Full text
Changes in salivary microbial sensing proteins CD14 and TLR2 with aging. / 07.2020 / PubMed / Full text
Association of CD14 with incident dementia and markers of brain aging and injury. / 21.01.2020 / PubMed / Full text
Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function. / 2019 / PubMed / Full text
Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. / 08.2019 / PubMed / Full text
Increased monocyte activation with age among HIV-infected long term non-progressor children: implications for early treatment initiation. / 09.2019 / PubMed / Full text
Wheat seed ageing viewed through the cellular redox environment and changes in pH. / 06.2019 / PubMed / Full text
Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals. / 26.02.2019 / PubMed / Full text
Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro. / 2018 / PubMed / Full text
Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text
Serum Zonulin and Endotoxin Levels in Exceptional Longevity versus Precocious Myocardial Infarction. / 04.2018 / PubMed / Full text
Rapid Turnover and High Production Rate of Myeloid Cells in Adult Rhesus Macaques with Compensations during Aging. / 15.06.2018 / PubMed / Full text
Human colostrum action against Giardia lamblia infection influenced by hormones and advanced maternal age. / 06.2018 / PubMed / Full text
The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence. / 15.02.2018 / PubMed / Full text
Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment. / 01.02.2018 / PubMed / Full text
Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™). / 04.2018 / PubMed / Full text
Acute Effects of Nitrate-Rich Beetroot Juice on Blood Pressure, Hemostasis and Vascular Inflammation Markers in Healthy Older Adults: A Randomized, Placebo-Controlled Crossover Study. / 22.11.2017 / PubMed / Full text
Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. / 02.2018 / PubMed / Full text
Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells. / 2017 / PubMed / Full text
HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble CD14 or D-Dimer. / 15.08.2017 / PubMed / Full text
Immunosenescence Induced by Plasma from Individuals with Obesity Caused Cell Signaling Dysfunction and Inflammation. / 09.2017 / PubMed / Full text
β -Microglobulin participates in development of lung emphysema by inducing lung epithelial cell senescence. / 01.05.2017 / PubMed / Full text
Age-dependent cellular reactions of the human immune system of humanized NOD scid gamma mice on LPS stimulus. / 04.2017 / PubMed / Full text
Immune Activation and Bacterial Translocation: A Link between Impaired Immune Recovery and Frequent Visceral Leishmaniasis Relapses in HIV-Infected Patients. / 2016 / PubMed / Full text
Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice. / 01.2017 / PubMed / Full text
Do Biomarkers of Inflammation, Monocyte Activation, and Altered Coagulation Explain Excess Mortality Between HIV Infected and Uninfected People? / 01.06.2016 / PubMed / Full text
Strain-dependent response to stimulation in middle-aged rat macrophages: A quest after a useful indicator of healthy aging. / 01.12.2016 / PubMed / Full text
Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology. / 02.2017 / PubMed / Full text
Red Wine Prevents the Acute Negative Vascular Effects of Smoking. / 01.2017 / PubMed / Full text
T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment. / 15.07.2016 / PubMed / Full text
Cytomegalovirus viral load within blood increases markedly in healthy people over the age of 70 years. / 2016 / PubMed / Full text
Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1-Infected Men. / 01.03.2016 / PubMed / Full text
Persistent Immune Activation and Carotid Atherosclerosis in HIV-Infected Ugandans Receiving Antiretroviral Therapy. / 01.02.2016 / PubMed / Full text
Visceral leishmaniasis as an independent cause of high immune activation, T-cell senescence, and lack of immune recovery in virologically suppressed HIV-1-coinfected patients. / 04.2015 / PubMed / Full text
Aging oppositely affects TNF-α and IL-10 production by macrophages from different rat strains. / 2014 / PubMed / Full text
Age-related changes in the features of porcine adult stem cells isolated from adipose tissue and skeletal muscle. / 01.10.2013 / PubMed / Full text
Lower levels of circulating progenitor cells are associated with low physical function and performance in elderly men with impaired glucose tolerance: a pilot substudy from the VA Enhanced Fitness trial. / 12.2013 / PubMed / Full text

CORT[править]

Sex differences in body composition, metabolism-related hormones, and energy homeostasis during aging in Wistar rats. / 10.2020 / PubMed / Full text
Effects of age and social isolation on murine hippocampal biochemistry and behavior. / 10.2020 / PubMed / Full text
Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice. / 10.2020 / PubMed / Full text
Sex- and age-dependent differences in the hormone and drinking responses to water deprivation. / 01.03.2020 / PubMed / Full text
Ontogeny of the adrenocortical response in an extremely altricial bird. / 12.2019 / PubMed / Full text
Exposure to jet lag aggravates depression-like behaviors and age-related phenotypes in rats subject to chronic corticosterone. / 05.08.2019 / PubMed / Full text
Hyperadrenocorticism of calorie restriction contributes to its anti-inflammatory action in mice. / 06.2019 / PubMed / Full text
Effect of chronic corticosterone-induced depression on circadian rhythms and age-related phenotypes in mice. / 01.12.2018 / PubMed / Full text
Early Life Stress Strengthens Trait Covariance: A Plastic Response That Results in Reduced Flexibility. / 11.2018 / PubMed / Full text
Both Basal and Acute Restraint Stress-Induced c-Fos Expression Is Influenced by Age in the Extended Amygdala and Brainstem Stress Centers in Male Rats. / 2018 / PubMed / Full text
Stress-induced corticosterone secretion covaries with working memory in aging. / 11.2018 / PubMed / Full text
Sex-specific differences in corticosterone secretion, behavioral phenotypes and expression of TrkB.T1 and TrkB.FL receptor isoforms: Impact of systemic TrkB inhibition and combinatory stress exposure in adolescence. / 30.08.2018 / PubMed / Full text
Lifelong Aerobic Exercise Reduces the Stress Response in Rats. / 15.04.2018 / PubMed / Full text
sst -receptor gene deletion exacerbates chronic stress-induced deficits: Consequences for emotional and cognitive ageing. / 30.08.2018 / PubMed / Full text
Chronic corticosterone-induced depression mediates premature aging in rats. / 15.03.2018 / PubMed / Full text
Effects of developmental conditions on glucocorticoid concentrations in adulthood depend on sex and foraging conditions. / 07.2017 / PubMed / Full text
Corticosterone Response as an Age-Specific Mediator of Nestling Body Mass in a Wild Passerine. / 07-08.2017 / PubMed / Full text
Impact of transportation duration on stress responses in day-old chicks from young and old breeders. / 06.2017 / PubMed / Full text
Long-term effects of adolescent stress on neophobic behaviors in zebra finches are modulated by social context when in adulthood. / 04.2017 / PubMed / Full text
A chronic increase of corticosterone age-dependently reduces systemic DNA damage from oxidation in rats. / 03.2017 / PubMed / Full text
Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation. / 15.05.2017 / PubMed / Full text
Ancestry trumps experience: Transgenerational but not early life stress affects the adult physiological stress response. / 01.2017 / PubMed / Full text
Chronic corticosterone treatment enhances extinction-induced depression in aged rats. / 11.2016 / PubMed / Full text
Effects of Ontogeny, Diel Rhythms, and Environmental Variation on the Adrenocortical Physiology of Semialtricial Black Kites (Milvus migrans). / 05-06.2016 / PubMed / Full text
Chronic intermittent ethanol exposure during adolescence: Effects on stress-induced social alterations and social drinking in adulthood. / 01.01.2017 / PubMed / Full text
Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling. / 05.2016 / PubMed / Full text
Short photoperiod condition increases susceptibility to stress in adolescent male rats. / 01.03.2016 / PubMed / Full text
Age and sex differences in c-Fos expression and serum corticosterone concentration following LPS treatment. / 01.10.2015 / PubMed / Full text
Diurnal and stress-induced intra-hippocampal corticosterone rise attenuated in 11β-HSD1-deficient mice: a microdialysis study in young and aged mice. / 03.2015 / PubMed / Full text
A comparison of the short- and long-term effects of corticosterone exposure on extinction in adolescence versus adulthood. / 12.2014 / PubMed / Full text
Variation in plasma corticosterone in migratory songbirds: a test of the migration-modulation hypothesis. / 09-10.2014 / PubMed / Full text
Calorie restriction and corticosterone elevation during lactation can each modulate adult male fear and anxiety-like behaviour. / 09.2014 / PubMed / Full text
Age-dependent effect of high cholesterol diets on anxiety-like behavior in elevated plus maze test in rats. / 01.09.2014 / PubMed / Full text
Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice. / 01.2015 / PubMed / Full text
Age-dependent sensitivity to glucocorticoids in the developing mouse basolateral nucleus of the amygdala. / 08.2014 / PubMed / Full text
Maternal effects underlie ageing costs of growth in the zebra finch (Taeniopygia guttata). / 2014 / PubMed / Full text
Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis. / 2014 / PubMed / Full text
Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging. / 08.2013 / PubMed / Full text
Stress hormones mediate predator-induced phenotypic plasticity in amphibian tadpoles. / 07.05.2013 / PubMed / Full text

ATR[править]

REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks. / 17.11.2020 / PubMed / Full text
Bloodstain age estimation through infrared spectroscopy and Chemometric models. / 11.2020 / PubMed / Full text
Artificial Intelligence and fourier-transform infrared spectroscopy for evaluating water-mediated degradation of lubricant oils. / 01.11.2020 / PubMed / Full text
Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells. / 01.09.2020 / PubMed / Full text
Kinetics of thermal degradation and lifetime study of poly(vinylidene fluoride) (PVDF) subjected to bioethanol fuel accelerated aging. / 07.2020 / PubMed / Full text
Supraphysiological protection from replication stress does not extend mammalian lifespan. / 06.04.2020 / PubMed / Full text
Assessing the Retest Reliability of Prefrontal EEG Markers of Brain Rhythm Slowing in the Eyes-Closed Resting State. / 09.2020 / PubMed / Full text
Effects of Hydrogen Peroxide and Sodium Hypochlorite Aging on Properties and Performance of Polyethersulfone Ultrafiltration Membrane. / 18.10.2019 / PubMed / Full text
NF-κB signaling in skin aging. / 12.2019 / PubMed / Full text
Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti - aging component α - lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation. / 01.01.2020 / PubMed / Full text
Effect of Nitrogen-Doped Graphene Oxide on the Aging Behavior of Nitrile-Butadiene Rubber. / 10.10.2019 / PubMed / Full text
Age-related dysfunction of the DNA damage response in intestinal stem cells. / 2019 / PubMed / Full text
Age-related variations in corneal geometry and their association with astigmatism: The Yamagata Study (Funagata). / 10.2018 / PubMed / Full text
Sex-related differences in corneal astigmatism and shape with age. / 09.2018 / PubMed / Full text
Aging-Resistant Functionalized LDH⁻SAS/Nitrile-Butadiene Rubber Composites: Preparation and Study of Aging Kinetics/Anti-Aging Mechanism. / 18.05.2018 / PubMed / Full text
[Protective effect of Wuzi Yanzong recipe on testicular DNA damage and apoptosis in natural ageing rats]. / 04.2018 / PubMed / Full text
Age-related changes in with-the-rule and oblique corneal astigmatism. / 09.2018 / PubMed / Full text
Investigation of the factors that influence lead accumulation onto polyethylene: Implication for potable water plumbing pipes. / 05.04.2018 / PubMed / Full text
Global mapping of transcription factor motifs in human aging. / 2018 / PubMed / Full text
Cross-Sectional and Longitudinal Investigation of the Power Vector in Astigmatism: The Yamagata Study (Funagata). / 01.2018 / PubMed / Full text
Glomerular and tubular effects of nitric oxide (NO) are regulated by angiotensin II (Ang II) in an age-dependent manner through activation of both angiotensin receptors (AT1Rs and AT2Rs) in conscious lambs. / 02.2018 / PubMed / Full text
Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome. / 15.07.2017 / PubMed / Full text
Increasing age in Achilles rupture patients over time. / 07.2017 / PubMed / Full text
Phospholipid-protein balance in affective disorders: Analysis of human blood serum using Raman and FTIR spectroscopy. A pilot study. / 30.11.2016 / PubMed / Full text
Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation. / 08.2016 / PubMed / Full text
Relationship between age, corneal astigmatism, and ocular dimensions with reference to astigmatism in eyes undergoing routine cataract surgery. / 04.2016 / PubMed / Full text
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. / 25.09.2015 / PubMed / Full text
Analysis of anterior corneal astigmatism before cataract surgery using power vector analysis in eyes of Korean patients. / 06.2015 / PubMed / Full text
Requirement of ATR for maintenance of intestinal stem cells in aging Drosophila. / 05.2015 / PubMed / Full text
Ambient temperature reduction extends lifespan via activating cellular degradation activity in an annual fish (Nothobranchius rachovii). / 2015 / PubMed / Full text
Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. / 01.04.2015 / PubMed / Full text
Structural investigation of donor age effect on human bone marrow mesenchymal stem cells: FTIR spectroscopy and imaging. / 2014 / PubMed / Full text
Gestational and lactational exposure to atrazine via the drinking water causes specific behavioral deficits and selectively alters monoaminergic systems in C57BL/6 mouse dams, juvenile and adult offspring. / 09.2014 / PubMed / Full text
Age-dependent dopaminergic dysfunction following fetal exposure to atrazine in SD rats. / 05.2014 / PubMed / Full text
Molecular characterization of collaborator of ARF (CARF) as a DNA damage response and cell cycle checkpoint regulatory protein. / 01.04.2014 / PubMed / Full text
p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses. / 10.2013 / PubMed / Full text
Caenorhabditis elegans ATR checkpoint kinase ATL-1 influences life span through mitochondrial maintenance. / 11.2013 / PubMed / Full text
Small molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-Seckel syndrome fibroblasts. / 09.2013 / PubMed / Full text

CCK[править]

Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis. / 23.11.2020 / PubMed / Full text
Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis. / 2020 / PubMed / Full text
Effects of Age on Acute Appetite-Related Responses to Whey-Protein Drinks, Including Energy Intake, Gastric Emptying, Blood Glucose, and Plasma Gut Hormone Concentrations-A Randomized Controlled Trial. / 06.04.2020 / PubMed / Full text
Lactose induced redox-dependent senescence and activated Nrf2 pathway. / 2019 / PubMed / Full text
Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells. / 03.12.2019 / PubMed / Full text
LncRNA AW112010 Promotes Mitochondrial Biogenesis and Hair Cell Survival: Implications for Age-Related Hearing Loss. / 2019 / PubMed / Full text
Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins. / 01.2020 / PubMed / Full text
Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms. / 04.11.2019 / PubMed / Full text
Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells. / 15.12.2019 / PubMed / Full text
[Ginsenoside Rg_1 induces leukemia stem cell senescence via SIRT1/TSC_2 signal axis]. / 06.2019 / PubMed / Full text
Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells. / 15.07.2019 / PubMed / Full text
Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray. / 08.2019 / PubMed / Full text
Long non-coding RNA-OIS1 inhibits HPV-positive, but not HPV-negative cervical squamous cell carcinoma by upregulating MTK-1. / 03.2019 / PubMed / Full text
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation. / 02.2019 / PubMed / Full text
MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway. / 2018 / PubMed / Full text
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text
Apelin/APJ axis improves angiotensin II-induced endothelial cell senescence through AMPK/SIRT1 signaling pathway. / 06.2018 / PubMed / Full text
Osthole Delays Tert-Butyl Hydroperoxide-Induced Premature Senescence in Neural Stem Cells. / 08.2018 / PubMed / Full text
N-Cadherin Attenuates High Glucose-Induced Nucleus Pulposus Cell Senescence Through Regulation of the ROS/NF-κB Pathway. / 2018 / PubMed / Full text
Localization of cholecystokinin in the zebrafish retina from larval to adult stage. / 07.2018 / PubMed / Full text
Glutamate-dependent regulation of food intake is altered with age through changes in NMDA receptor phenotypes on vagal afferent neurons. / 15.05.2018 / PubMed / Full text
Effects of Substitution, and Adding of Carbohydrate and Fat to Whey-Protein on Energy Intake, Appetite, Gastric Emptying, Glucose, Insulin, Ghrelin, CCK and GLP-1 in Healthy Older Men-A Randomized Controlled Trial. / 23.01.2018 / PubMed / Full text
Effect of Age on Blood Glucose and Plasma Insulin, Glucagon, Ghrelin, CCK, GIP, and GLP-1 Responses to Whey Protein Ingestion. / 21.12.2017 / PubMed / Full text
Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation / 27.09.2017 / PubMed / Full text
[Effects of ginseng, notoginseng, and Chuanxiong Rhizoma extracts on cytoskeleton protein of replicative senescence vascular smooth muscle cells]. / 02.2016 / PubMed / Full text
[Inula Britannica flower total flavonoids reduces the apoptosis of aging bone marrow mesenchymal stem cells by anti-oxidation]. / 05.2017 / PubMed
[The mechanism of bone marrow-derived mesenchymal stem cells excessive senescence in severe aplastic anemia mouse model]. / 14.04.2017 / PubMed / Full text
Overexpression of miR-584-5p inhibits proliferation and induces apoptosis by targeting WW domain-containing E3 ubiquitin protein ligase 1 in gastric cancer. / 21.04.2017 / PubMed / Full text
Molecular mechanism of G arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells. / 2017 / PubMed / Full text
Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes. / 2016 / PubMed / Full text
Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. / 2016 / PubMed
Cholecystokinin expression in the β-cell leads to increased β-cell area in aged mice and protects from streptozotocin-induced diabetes and apoptosis. / 15.11.2015 / PubMed / Full text
Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma. / 10.2015 / PubMed / Full text
The positive effects of Ginsenoside Rg1 upon the hematopoietic microenvironment in a D-Galactose-induced aged rat model. / 15.04.2015 / PubMed / Full text
Exposure to a high fat diet during the perinatal period alters vagal motoneurone excitability, even in the absence of obesity. / 01.01.2015 / PubMed / Full text
Ionizing irradiation inhibits keloid fibroblast cell proliferation and induces premature cellular senescence. / 01.2015 / PubMed / Full text
Age and nutritional state influence the effects of cholecystokinin on energy balance. / 11.2013 / PubMed / Full text
Age-associated changes in pancreatic exocrine secretion of the isolated perfused rat pancreas. / 03.2013 / PubMed / Full text

FOXO1[править]

The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high-fat diet-fed obese rats. / 09.2020 / PubMed / Full text
Ginsenoside Rg1 protects against d-galactose induced fatty liver disease in a mouse model via FOXO1 transcriptional factor. / 01.08.2020 / PubMed / Full text
Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides. / 06.2020 / PubMed / Full text
l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation. / 03.2020 / PubMed / Full text
Increased REST to Optimize Life Span? / 12.2019 / PubMed / Full text
Regulation of lifespan by neural excitation and REST. / 10.2019 / PubMed / Full text
Herbal Medicine for Slowing Aging and Aging-associated Conditions: Efficacy, Mechanisms and Safety. / 2020 / PubMed / Full text
Establishment of a Mouse Model of Premature Ovarian Failure Using Consecutive Superovulation. / 2018 / PubMed / Full text
Functional pathways regulated by microRNA networks in CD8 T-cell aging. / 02.2019 / PubMed / Full text
Introduction to FOXO Biology. / 2019 / PubMed / Full text
Antioxidant modifications induced by the new metformin derivative HL156A regulate metabolic reprogramming in SAMP1/kl (-/-) mice. / 16.09.2018 / PubMed / Full text
Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls. / 10.2018 / PubMed / Full text
FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence. / 01.2019 / PubMed / Full text
Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging. / 25.09.2018 / PubMed / Full text
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration. / 10.2018 / PubMed / Full text
Senescence Alters PPARγ (Peroxisome Proliferator-Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors Inflammation. / 05.2018 / PubMed / Full text
HGF and BFGF Secretion by Human Adipose-Derived Stem Cells Improves Ovarian Function During Natural Aging via Activation of the SIRT1/FOXO1 Signaling Pathway. / 2018 / PubMed / Full text
Role of Forkhead Box O (FOXO) transcription factor in aging and diseases. / 30.03.2018 / PubMed / Full text
FOXO in Neural Cells and Diseases of the Nervous System. / 2018 / PubMed / Full text
Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium. / 11.12.2017 / PubMed / Full text
FOXO Transcriptional Factors and Long-Term Living. / 2017 / PubMed / Full text
Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis. / 01.09.2017 / PubMed / Full text
The protein kinase MBK-1 contributes to lifespan extension in [i]daf-2[/i] mutant and germline-deficient [i]Caenorhabditis elegans[/i]. / 25.05.2017 / PubMed / Full text
Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. / 2017 / PubMed / Full text
Caloric restriction delays early phases of carcinogenesis via effects on the tissue microenvironment. / 30.05.2017 / PubMed / Full text
Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration. / 12.2017 / PubMed / Full text
Oxidative Stress-Induced miR-200c Disrupts the Regulatory Loop Among SIRT1, FOXO1, and eNOS. / 20.08.2017 / PubMed / Full text
miR-96, miR-145 and miR-9 expression increases, and IGF-1R and FOXO1 expression decreases in peripheral blood mononuclear cells of aging humans. / 30.11.2016 / PubMed / Full text
Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling. / 01.01.2016 / PubMed / Full text
Effect of Aging on Periodontal Inflammation, Microbial Colonization, and Disease Susceptibility. / 04.2016 / PubMed / Full text
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. / 04.2016 / PubMed / Full text
Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase. / 01.2016 / PubMed / Full text
Endogenous ROS levels are increased in replicative senescence in human bone marrow mesenchymal stromal cells. / 15.05.2015 / PubMed / Full text
Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis. / 01.2014 / PubMed / Full text
Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. / 09.2013 / PubMed / Full text
Age-related changes of forkhead transcription factor FOXO1 in the liver of senescence-accelerated mouse SAMP8. / 11-12.2013 / PubMed / Full text
Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells. / 01.05.2013 / PubMed / Full text
SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway. / 12.2013 / PubMed / Full text

MYC[править]

A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma. / 13.10.2020 / PubMed / Full text
Enhanced proliferative capacity of human preadipocytes achieved by an optimized cultivating method that induces transient activity of hTERT. / 20.08.2020 / PubMed / Full text
Collaboration of MYC and RUNX2 in lymphoma simulates T-cell receptor signaling and attenuates p53 pathway activity. / 10.2019 / PubMed / Full text
Regulation of RhoB Gene Expression during Tumorigenesis and Aging Process and Its Potential Applications in These Processes. / 13.06.2019 / PubMed / Full text
Transcriptomic analysis of human IL-7 receptor alpha and effector memory CD8 T cells reveals an age-associated signature linked to influenza vaccine response in older adults. / 08.2019 / PubMed / Full text
SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice. / 06.2019 / PubMed / Full text
Profound, durable and MGMT-independent sensitivity of glioblastoma cells to cyclin-dependent kinase inhibition. / 01.07.2019 / PubMed / Full text
MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts. / 2018 / PubMed / Full text
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. / 02.10.2018 / PubMed / Full text
O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. / 01.11.2018 / PubMed / Full text
Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
E47 Governs the MYC-CDKN1B/p27 -RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16 and Wild-Type p53. / 2018 / PubMed / Full text
Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. / 2018 / PubMed / Full text
MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. / 10.04.2018 / PubMed / Full text
Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways. / 27.03.2018 / PubMed / Full text
Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults. / 04.2018 / PubMed / Full text
Modulation of dietary folate with age confers selective hepatocellular epigenetic imprints through DNA methylation. / 03.2018 / PubMed / Full text
Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses. / 01.02.2019 / PubMed / Full text
MYC Modulation around the CDK2/p27/SKP2 Axis. / 30.06.2017 / PubMed / Full text
Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. / 01.09.2017 / PubMed / Full text
Nickel-induced HIF-1α promotes growth arrest and senescence in normal human cells but lacks toxic effects in transformed cells. / 15.09.2017 / PubMed / Full text
Role of p16 and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells. / 08.2017 / PubMed / Full text
The RUNX Genes as Conditional Oncogenes: Insights from Retroviral Targeting and Mouse Models. / 2017 / PubMed / Full text
Protection against High-Fat-Diet-Induced Obesity in MDM2 Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure. / 24.01.2017 / PubMed / Full text
Downregulation of CITED2 contributes to TGFβ-mediated senescence of tendon-derived stem cells. / 04.2017 / PubMed / Full text
STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. / 16.02.2017 / PubMed / Full text
Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans. / 15.12.2016 / PubMed / Full text
Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases. / 04.11.2016 / PubMed / Full text
Mitochondrial function in hypoxic ischemic injury and influence of aging. / 10.2017 / PubMed / Full text
JAZ7 negatively regulates dark-induced leaf senescence in Arabidopsis. / 02.2016 / PubMed / Full text
ARF: connecting senescence and innate immunity for clearance. / 09.2015 / PubMed / Full text
Reduced expression of MYC increases longevity and enhances healthspan. / 29.01.2015 / PubMed / Full text
Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations. / 2014 / PubMed / Full text
DNA and RNA quadruplex-binding proteins. / 29.09.2014 / PubMed / Full text
Aging and injury: alterations in cellular energetics and organ function. / 04.2014 / PubMed / Full text
PLA2R1: expression and function in cancer. / 08.2014 / PubMed / Full text
Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis. / 06.2014 / PubMed / Full text
Passage-dependent cancerous transformation of human mesenchymal stem cells under carcinogenic hypoxia. / 07.2013 / PubMed / Full text

STS[править]

Delayed Impairment of Postural, Physical, and Muscular Functions Following Downhill Compared to Level Walking in Older People. / 2020 / PubMed / Full text
Novel Resistance Training Approach to Monitoring the Volume in Older Adults: The Role of Movement Velocity. / 17.10.2020 / PubMed / Full text
Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells. / 06.10.2020 / PubMed / Full text
Sodium tanshinone IIA sulfonate restrains fibrogenesis through induction of senescence in mice with induced deep endometriosis. / 09.2020 / PubMed / Full text
The WRKY53 transcription factor enhances stilbene synthesis and disease resistance by interacting with MYB14 and MYB15 in Chinese wild grape. / 30.05.2020 / PubMed / Full text
On the role of ageing and musculoskeletal pain on dynamic balance in manual workers. / 02.2020 / PubMed / Full text
The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years. / 12.2019 / PubMed / Full text
30-day mortality in frail patients undergoing cardiac surgery: the results of the [i]frailty in cardiac surgery (FICS) copenhagen study[/i]. / 12.2019 / PubMed / Full text
Chronic Fish Oil Consumption with Resistance Training Improves Grip Strength, Physical Function, and Blood Pressure in Community-Dwelling Older Adults. / 09.07.2019 / PubMed / Full text
Effects of Tai Chi versus Taekkyon on balance, lower-extremity strength, and gait ability in community-dwelling older women: A single-blinded randomized clinical trial. / 2020 / PubMed / Full text
Short-term starvation stress at young adult stages enhances meiotic activity of germ cells to maintain spermatogenesis in aged male Caenorhabditis elegans. / 06.2019 / PubMed / Full text
Flexibility in joint coordination remains unaffected by force and balance demands in young and old adults during simple sit-to-stand tasks. / 02.2019 / PubMed / Full text
The influence of knee extensor fatigue on lower extremity muscle activity during chair rise in young and older adults. / 01.2019 / PubMed / Full text
The sit-to-stand muscle power test: An easy, inexpensive and portable procedure to assess muscle power in older people. / 02.10.2018 / PubMed / Full text
Visual-Vestibular Interaction for Postural Control During Sit-to-Stand: Effects of Aging. / 01.01.2019 / PubMed / Full text
From Intervention to Co-constitution: New Directions in Theorizing about Aging and Technology. / 09.01.2019 / PubMed / Full text
Age-related Changes in Postural Sway During Sit-to-stand in Typical Children and Children with Cerebral Palsy. / 2019 / PubMed / Full text
Ectopic expression of VpSTS29, a stilbene synthase gene from Vitis pseudoreticulata, indicates STS presence in cytosolic oil bodies. / 07.2018 / PubMed / Full text
Short-Term Training and Detraining Effects of Supervised vs. Unsupervised Resistance Exercise in Aging Adults. / 10.2019 / PubMed / Full text
The coordination of joint movements during sit-to-stand motion in old adults: the uncontrolled manifold analysis. / 2017 / PubMed / Full text
The role of thigh muscular efforts in limiting sit-to-stand capacity in healthy young and older adults. / 12.2017 / PubMed / Full text
Hippocampal structure predicts cortical indices of reactivation of related items. / 27.01.2017 / PubMed / Full text
Aortic Valve Replacement With or Without Concurrent Coronary Artery Bypass Grafting in Octogenarians: Eight-Year Cohort Study. / 01.2017 / PubMed / Full text
Anatomical cross-sectional area of the quadriceps femoris and sit-to-stand test score in middle-aged and elderly population: development of a predictive equation. / 29.06.2016 / PubMed / Full text
Association between Physical Fitness and Successful Aging in Taiwanese Older Adults. / 2016 / PubMed / Full text
Is this STS work-related? ISO 1999 predictions as an adjunct to clinical judgment. / 12.2015 / PubMed / Full text
Effects of Strength Training Using Unstable Surfaces on Strength, Power and Balance Performance Across the Lifespan: A Systematic Review and Meta-analysis. / 12.2015 / PubMed / Full text
Lean Body Mass Associated with Upper Body Strength in Healthy Older Adults While Higher Body Fat Limits Lower Extremity Performance and Endurance. / 26.08.2015 / PubMed / Full text
Psychometric properties of the Swedish version of the Self-Transcendence Scale among very old people. / 2015 / PubMed / Full text
Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus. / 2015 / PubMed / Full text
Kinematic analysis of motor strategies in frail aged adults during the Timed Up and Go: how to spot the motor frailty? / 2015 / PubMed / Full text
Sit-to-stand test: Performance and determinants across the age-span. / 2010 / PubMed / Full text
Developing a measure of muscular power during a functional task for older adults. / 30.12.2014 / PubMed / Full text
Behavior and neural correlates of empathy in adolescents. / 2014 / PubMed / Full text
Can sit-to-stand lower limb muscle power predict fall status? / 07.2014 / PubMed / Full text
Physical working capacity at fatigue threshold (PWCFT) is associated with sarcopenia-related body composition and measures of functionality in older adults. / 09-10.2014 / PubMed / Full text
Expression of an AtNAP gene homolog in senescing morning glory (Ipomoea nil) petals of two cultivars with a different flower life span. / 01.05.2014 / PubMed / Full text
Region of stability derived by center of mass acceleration better identifies individuals with difficulty in sit-to-stand movement. / 04.2014 / PubMed / Full text

CD38[править]

Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction. / 02.11.2020 / PubMed / Full text
Macrophage Immunometabolism and Inflammaging: Roles of Mitochondrial Dysfunction, Cellular Senescence, CD38, and NAD. / 2020 / PubMed / Full text
TNFRSF12A and CD38 Contribute to a Vicious Circle for Chronic Obstructive Pulmonary Disease by Engaging Senescence Pathways. / 2020 / PubMed / Full text
Aging alters acetylation status in skeletal and cardiac muscles. / 06.2020 / PubMed / Full text
CD38 in Neurodegeneration and Neuroinflammation. / 18.02.2020 / PubMed / Full text
CD38, a Receptor with Multifunctional Activities: From Modulatory Functions on Regulatory Cell Subsets and Extracellular Vesicles, to a Target for Therapeutic Strategies. / 27.11.2019 / PubMed / Full text
Age-related alterations in human gut CD4 T cell phenotype, T helper cell frequencies, and functional responses to enteric bacteria. / 01.2020 / PubMed / Full text
CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD /Sirt1 Signaling Pathway. / 2019 / PubMed / Full text
Metabolism and biochemical properties of nicotinamide adenine dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD). / 11.09.2019 / PubMed / Full text
The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases. / 2019 / PubMed / Full text
Interacting NAD and Cell Senescence Pathways Complicate Antiaging Therapies. / 06.2019 / PubMed / Full text
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD decline. / 28.05.2019 / PubMed / Full text
Measuring CD38 Hydrolase and Cyclase Activities: 1,N -Ethenonicotinamide Adenine Dinucleotide (ε-NAD) and Nicotinamide Guanine Dinucleotide (NGD) Fluorescence-based Methods. / 20.07.2018 / PubMed / Full text
The Plasma NAD Metabolome Is Dysregulated in "Normal" Aging. / 04.2019 / PubMed / Full text
Assays for NAD -Dependent Reactions and NAD Metabolites. / 2018 / PubMed / Full text
Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition. / 10.2018 / PubMed / Full text
Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text
Abnormalities of age-related T cell senescence in Parkinson's disease. / 28.05.2018 / PubMed / Full text
A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD Decline. / 01.05.2018 / PubMed / Full text
Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes. / 10.01.2019 / PubMed / Full text
Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161 TCR iVα7.2 Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection. / 2018 / PubMed / Full text
The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging. / 04.2018 / PubMed / Full text
NAD Deficiency Is a Common Central Pathological Factor of a Number of Diseases and Aging: Mechanisms and Therapeutic Implications. / 20.02.2019 / PubMed / Full text
Reevaluation of immune activation in the era of cART and an aging HIV-infected population. / 19.10.2017 / PubMed / Full text
Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. / 17.08.2017 / PubMed / Full text
Age dependent differences in the kinetics of γδ T cells after influenza vaccination. / 2017 / PubMed / Full text
NAD and the aging process: Role in life, death and everything in between. / 05.11.2017 / PubMed / Full text
Constitutive Expression of Inducible Cyclic Adenosine Monophosphate Early Repressor (ICER) in Cycling Quiescent Hematopoietic Cells: Implications for Aging Hematopoietic Stem Cells. / 02.2017 / PubMed / Full text
Why NAD( ) Declines during Aging: It's Destroyed. / 14.06.2016 / PubMed / Full text
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. / 14.06.2016 / PubMed / Full text
Immunity in young adult survivors of childhood leukemia is similar to the elderly rather than age-matched controls: Role of cytomegalovirus. / 07.2016 / PubMed / Full text
Aging of immune system: Immune signature from peripheral blood lymphocyte subsets in 1068 healthy adults. / 05.2016 / PubMed / Full text
Peripheral loss of CD8( ) CD161( ) TCRVα7·2( ) mucosal-associated invariant T cells in chronic hepatitis C virus-infected patients. / 02.2016 / PubMed / Full text
Probiotics Reduce Inflammation in Antiretroviral Treated, HIV-Infected Individuals: Results of the "Probio-HIV" Clinical Trial. / 2015 / PubMed / Full text
Concurrent loss of co-stimulatory molecules and functional cytokine secretion attributes leads to proliferative senescence of CD8( ) T cells in HIV/TB co-infection. / 09.2015 / PubMed / Full text
Mapping NAD( ) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence. / 04.2014 / PubMed / Full text
Accelerated aging in HIV/AIDS: novel biomarkers of senescent human CD8 T cells. / 2013 / PubMed / Full text

CDK4[править]

Emerging Roles for the [i]INK4a/ARF[/i] ([i]CDKN2A[/i]) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes. / 22.09.2020 / PubMed / Full text
Guilu Erxian Glue () Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16 -Rb Signaling Pathway. / 11.2020 / PubMed / Full text
Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice. / 15.08.2020 / PubMed / Full text
Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism. / 08.2020 / PubMed / Full text
Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion. / 2019 / PubMed / Full text
Anti-cell growth and anti-cancer stem cell activity of the CDK4/6 inhibitor palbociclib in breast cancer cells. / 05.2020 / PubMed / Full text
Compromising the constitutive p16 expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence. / 04.2020 / PubMed / Full text
Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential. / 22.05.2020 / PubMed / Full text
Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex. / 03-04.2019 / PubMed / Full text
p16 deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence. / 09.2019 / PubMed / Full text
Efficient immortalization of cells derived from critically endangered Tsushima leopard cat (Prionailurus bengalensis euptilurus) with expression of mutant CDK4, Cyclin D1, and telomerase reverse transcriptase. / 12.2018 / PubMed / Full text
Effects of Fibronectin 1 on Cell Proliferation, Senescence and Apoptosis of Human Glioma Cells Through the PI3K/AKT Signaling Pathway. / 2018 / PubMed / Full text
Cyclin D1 depletion interferes with oxidative balance and promotes cancer cell senescence. / 25.06.2018 / PubMed / Full text
Fucoidan Rescues p-Cresol-Induced Cellular Senescence in Mesenchymal Stem Cells via FAK-Akt-TWIST Axis. / 06.04.2018 / PubMed / Full text
Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors. / 2018 / PubMed / Full text
Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis. / 02.03.2018 / PubMed / Full text
Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. / 08.01.2018 / PubMed / Full text
Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. / 19.09.2017 / PubMed / Full text
Immortalized prairie vole-derived fibroblasts (VMF-K4DTs) can be transformed into pluripotent stem cells and provide a useful tool with which to determine optimal reprogramming conditions. / 21.06.2017 / PubMed / Full text
Molecular mechanism of G arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells. / 2017 / PubMed / Full text
p16 loss rescues functional decline of Brca1-deficient mammary stem cells. / 18.04.2017 / PubMed / Full text
p16 enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction. / 07.2017 / PubMed / Full text
p16INK4a suppresses BRCA1-deficient mammary tumorigenesis. / 20.12.2016 / PubMed / Full text
A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1. / 27.09.2016 / PubMed / Full text
CDK4-CDK6 inhibitors induce autophagy-mediated degradation of DNMT1 and facilitate the senescence antitumor response. / 02.10.2016 / PubMed / Full text
Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine. / 22.01.2016 / PubMed / Full text
Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA. / 01.12.2015 / PubMed / Full text
Suppression of RAD21 Induces Senescence of MDA-MB-231 Human Breast Cancer Cells Through RB1 Pathway Activation Via c-Myc Downregulation. / 06.2016 / PubMed / Full text
Molecular differences between stromal cell populations from deciduous and permanent human teeth. / 18.04.2015 / PubMed / Full text
Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells. / 29.05.2015 / PubMed / Full text
MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. / 10.04.2015 / PubMed / Full text
Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence. / 2015 / PubMed / Full text
MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer. / 07.2014 / PubMed / Full text
Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes. / 15.08.2013 / PubMed / Full text
Oxidized low-density lipoprotein induces hematopoietic stem cell senescence. / 09.2013 / PubMed / Full text

EGFR[править]

Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model. / 2020 / PubMed / Full text
Catalog of Lung Cancer Gene Mutations Among Chinese Patients. / 2020 / PubMed / Full text
Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines. / 05.2020 / PubMed / Full text
Comparative effectiveness and cost-effectiveness of three first-line EGFR-tyrosine kinase inhibitors: Analysis of real-world data in a tertiary hospital in Taiwan. / 2020 / PubMed / Full text
An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis. / 01.05.2020 / PubMed / Full text
Different cellular properties and loss of nuclear signalling of porcine epidermal growth factor receptor with aging. / 01.05.2020 / PubMed / Full text
Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. / 13.01.2020 / PubMed / Full text
Association between EGFR mutation and ageing, history of pneumonia and gastroesophageal reflux disease among patients with advanced lung cancer. / 11.2019 / PubMed / Full text
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression. / 12.2019 / PubMed / Full text
Systems biology and network pharmacology of frailty reveal novel epigenetic targets and mechanisms. / 22.07.2019 / PubMed / Full text
The role of EGFR signaling in age-related osteoporosis in mouse cortical bone. / 10.2019 / PubMed / Full text
Regulation of RhoB Gene Expression during Tumorigenesis and Aging Process and Its Potential Applications in These Processes. / 13.06.2019 / PubMed / Full text
EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence. / 04.12.2018 / PubMed / Full text
An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. / 06.2019 / PubMed / Full text
Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase. / 09.08.2018 / PubMed / Full text
Novel drug-resistance mechanisms of pemetrexed-treated non-small cell lung cancer. / 30.03.2018 / PubMed / Full text
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans. / 04.2018 / PubMed / Full text
30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Nongenomic effects via the mineralocorticoid receptor. / 07.2017 / PubMed / Full text
Inverse relationship between Alzheimer's disease and cancer, and other factors contributing to Alzheimer's disease: a systematic review. / 22.11.2016 / PubMed / Full text
Low-frequency [i]KRAS[/i] mutations are prevalent in lung adenocarcinomas. / 03.2015 / PubMed / Full text
Association of Polymorphisms in Connective Tissue Growth Factor and Epidermal Growth Factor Receptor Genes With Human Longevity. / 01.08.2017 / PubMed / Full text
sPLA2 -IIA Overexpression in Mice Epidermis Depletes Hair Follicle Stem Cells and Induces Differentiation Mediated Through Enhanced JNK/c-Jun Activation. / 09.2016 / PubMed / Full text
Mechanisms of skin aging induced by EGFR inhibitors. / 10.2016 / PubMed / Full text
Prolactin, EGFR, vimentin and α-actin profiles in elderly rat prostate subjected to steroid hormonal imbalance. / 06.2016 / PubMed / Full text
Loss of Maspardin Attenuates the Growth and Maturation of Mouse Cortical Neurons. / 2016 / PubMed / Full text
Expression profile analysis of new candidate genes for the therapy of primary osteoporosis. / 2016 / PubMed
Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature. / 05.2016 / PubMed / Full text
Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways. / 22.09.2015 / PubMed / Full text
First-line gefitinib treatment in elderly patients (aged ≥75 years) with non-small cell lung cancer harboring EGFR mutations. / 10.2015 / PubMed / Full text
Increased centrosome amplification in aged stem cells of the Drosophila midgut. / 25.07.2014 / PubMed / Full text
Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. / 07.05.2014 / PubMed / Full text
Thiamin concentration in geriatric hospitalized patients using frusemide. / 2014 / PubMed / Full text
4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts. / 06.2014 / PubMed / Full text
Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). / 01.11.2013 / PubMed / Full text
Clinical significance of proliferation, apoptosis and senescence of nasopharyngeal cells by the simultaneously blocking EGF, IGF-1 receptors and Bcl-xl genes. / 01.11.2013 / PubMed / Full text
EGFR inhibitor erlotinib delays disease progression but does not extend survival in the SOD1 mouse model of ALS. / 2013 / PubMed / Full text
Gene-guided gefitinib switch maintenance therapy for patients with advanced EGFR mutation-positive non-small cell lung cancer: an economic analysis. / 29.01.2013 / PubMed / Full text

BACE1[править]

Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats. / 2020 / PubMed / Full text
Dendrobium nobile Lindl. Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity. / 2020 / PubMed / Full text
Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity. / 05.2020 / PubMed / Full text
Age- and sex-dependent profiles of APP fragments and key secretases align with changes in despair-like behavior and cognition in young APPSwe/Ind mice. / 02.04.2019 / PubMed / Full text
Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice. / 03.2019 / PubMed / Full text
Temporal Effects of Neuron-specific beta-secretase 1 (BACE1) Knock-in on the Mouse Brain Metabolome: Implications for Alzheimer's Disease. / 15.01.2019 / PubMed / Full text
Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice. / 07.2019 / PubMed / Full text
Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice. / 19.09.2018 / PubMed / Full text
Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease. / 10.2018 / PubMed / Full text
Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells. / 15.01.2018 / PubMed / Full text
Neuroprotective potential of high-dose biotin. / 11.2017 / PubMed / Full text
The pathological roles of NDRG2 in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells. / 08.2017 / PubMed / Full text
Ferulic Acid Suppresses Amyloid [i]β[/i] Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide. / 2017 / PubMed / Full text
Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice. / 2017 / PubMed / Full text
Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition. / 06.2017 / PubMed / Full text
Fuzhisan Ameliorates the Memory Deficits in Aged SAMP8 Mice via Decreasing Aβ Production and Tau Hyperphosphorylation of the Hippocampus. / 11.2016 / PubMed / Full text
Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence. / 07.2016 / PubMed / Full text
Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF. / 03.2016 / PubMed / Full text
miR-186 is decreased in aged brain and suppresses BACE1 expression. / 05.2016 / PubMed / Full text
IL-17A is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation. / 15.09.2015 / PubMed / Full text
Functions of miR-9 and miR-9* during Aging in SAMP8 Mice and Their Possible Mechanisms. / 06.2015 / PubMed / Full text
SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation. / 08.2016 / PubMed / Full text
Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain. / 02.05.2015 / PubMed / Full text
The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice. / 06.2015 / PubMed / Full text
Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model. / 13.09.2014 / PubMed / Full text
Development and characterization of an aged onset model of Alzheimer's disease in Drosophila melanogaster. / 11.2014 / PubMed / Full text
Sildenafil Decreases BACE1 and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse. / 06.2015 / PubMed / Full text
Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation. / 10.2014 / PubMed / Full text
Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. / 02.05.2014 / PubMed / Full text
Lessons from a BACE1 inhibitor trial: off-site but not off base. / 10.2014 / PubMed / Full text
Expression of amyloid-associated miRNAs in both the forebrain cortex and hippocampus of middle-aged rat. / 2014 / PubMed / Full text
MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects. / 21.02.2014 / PubMed / Full text
Rheb GTPase regulates β-secretase levels and amyloid β generation. / 28.02.2014 / PubMed / Full text
Can BACE1 inhibition mitigate early axonal pathology in neurological diseases? / 2014 / PubMed / Full text
Stress contributes to the development of central insulin resistance during aging: implications for Alzheimer's disease. / 12.2013 / PubMed / Full text
[Effect of PNS on the activity and content of BACE1 in the brain of SAMP8 mice with Alzheimer's disease]. / 07.2013 / PubMed

LBP[править]

Age-Related Colonic Mucosal Microbiome Community Shifts in Monkeys. / 06.10.2020 / PubMed / Full text
Lipopolysaccharide binding protein is associated with CVD risk in older adults. / 08.09.2020 / PubMed / Full text
Influence of Frailty Status on Pain, Disability, and Quality of Life in Older Adults with Acute Low Back Pain: Results from the Back Complaints in the Elders (BACE-Brazil) Study. / 14.08.2020 / PubMed / Full text
Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels. / 01.04.2020 / PubMed / Full text
Distal colonic transit is linked to gut microbiota diversity and microbial fermentation in humans with slow colonic transit. / 01.02.2020 / PubMed / Full text
Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations. / 12.2019 / PubMed / Full text
Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein. / 03.2020 / PubMed / Full text
Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)-Brazil. / 03.2020 / PubMed / Full text
Effects of Lycium barbarum Polysaccharides on Health and Aging of [i]C. elegans[/i] Depend on [i]daf-12/daf-16[/i]. / 2019 / PubMed / Full text
Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8. / 10.07.2019 / PubMed / Full text
Lycium barbarum polysaccharides extend the mean lifespan of Drosophila melanogaster. / 17.07.2019 / PubMed / Full text
Height loss but not body composition is related to low back pain in community-dwelling elderlies: Shimane CoHRE study. / 10.05.2019 / PubMed / Full text
Aging of mouse intervertebral disc and association with back pain. / 06.2019 / PubMed / Full text
A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats. / 19.03.2019 / PubMed / Full text
Chen-Style Tai Chi for Individuals (Aged 50 Years Old or Above) with Chronic Non-Specific Low Back Pain: A Randomized Controlled Trial. / 12.02.2019 / PubMed / Full text
Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity. / 11.03.2019 / PubMed / Full text
Factors associated with lumbar disc high-intensity zone (HIZ) on T2-weighted magnetic resonance image: a retrospective study of 3185 discs in 637 patients. / 04.12.2018 / PubMed / Full text
Urolithin A Inhibits the Catabolic Effect of TNFα on Nucleus Pulposus Cell and Alleviates Intervertebral Disc Degeneration [i]in vivo[/i]. / 2018 / PubMed / Full text
Use of trunk muscle training and neuromuscular electrical stimulation to reduce pain and disability in an older adult with chronic low back pain: A case report. / 08.2019 / PubMed / Full text
Endotoxemia is modulated by quantity and quality of dietary fat in older adults. / 08.2018 / PubMed / Full text
Correlates of a Recent History of Disabling Low Back Pain in Community-dwelling Older Persons: The Pain in the Elderly (PAINEL) Study. / 06.2018 / PubMed / Full text
The Effectiveness and Safety of Manual Therapy on Pain and Disability in Older Persons With Chronic Low Back Pain: A Systematic Review. / 09.2017 / PubMed / Full text
De-educate to re-educate: aging and low back pain. / 12.2017 / PubMed / Full text
Activity of Erector Spinae During Trunk Forward Bending and Backward Return: The Effects of Age. / 06.2017 / PubMed / Full text
Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity. / 18.08.2016 / PubMed / Full text
Age- and brain region-dependent α-synuclein oligomerization is attributed to alterations in intrinsic enzymes regulating α-synuclein phosphorylation in aging monkey brains. / 23.02.2016 / PubMed / Full text
Association of Lipopolysaccharide-Binding Protein With Aging-Related Adiposity Change and Prediabetes Among African Ancestry Men. / 03.2016 / PubMed / Full text
Age-related differences in trunk intrinsic stiffness. / 11.04.2016 / PubMed / Full text
Probiotics Reduce Inflammation in Antiretroviral Treated, HIV-Infected Individuals: Results of the "Probio-HIV" Clinical Trial. / 2015 / PubMed / Full text
The effects of age and gender on the lumbopelvic rhythm in the sagittal plane in 309 subjects. / 18.09.2015 / PubMed / Full text
Does physical activity moderate the relationship between depression symptomatology and low back pain? Cohort and co-twin control analyses nested in the longitudinal study of aging Danish twins (LSADT). / 04.2016 / PubMed / Full text
Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans. / 02.01.2015 / PubMed / Full text
Comparative study of human age estimation with or without preclassification of gender and facial expression. / 2014 / PubMed / Full text
Treatment of d-galactose induced mouse aging with Lycium barbarum polysaccharides and its mechanism study. / 2013 / PubMed / Full text
A study of Lycium barbarum polysaccharides (LBP) extraction technology and its anti-aging effect. / 2013 / PubMed / Full text
Paraspinal muscle morphology and composition: a 15-yr longitudinal magnetic resonance imaging study. / 2014 / PubMed / Full text

DMD[править]

Aldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients. / 08.2020 / PubMed / Full text
Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta-analysis. / 07.2020 / PubMed / Full text
Control of Muscle Fibro-Adipogenic Progenitors by Myogenic Lineage is Altered in Aging and Duchenne Muscular Dystrophy. / 2019 / PubMed / Full text
Renal dysfunction can occur in advanced-stage Duchenne muscular dystrophy. / 02.2020 / PubMed / Full text
The long dystrophin gene product Dp427 modulates retinal function and vascular morphology in response to age and retinal ischemia. / 10.2019 / PubMed / Full text
Hemojuvelin is a novel suppressor for Duchenne muscular dystrophy and age-related muscle wasting. / 06.2019 / PubMed / Full text
Age-dependent changes in metabolite profile and lipid saturation in dystrophic mice. / 05.2019 / PubMed / Full text
Muscle function and age are associated with loss of bone mineral density in Duchenne muscular dystrophy. / 04.2019 / PubMed / Full text
Use of bone age for evaluating bone density in patients with Duchenne muscular dystrophy: A preliminary report. / 04.2019 / PubMed / Full text
Age- and Expertise-Related Differences of Sensorimotor Network Dynamics during Force Control. / 15.09.2018 / PubMed / Full text
Mineralocorticoid Receptor Antagonists in Muscular Dystrophy Mice During Aging and Exercise. / 2018 / PubMed / Full text
Calcium current properties in dystrophin-deficient ventricular cardiomyocytes from aged mdx mice. / 01.2018 / PubMed / Full text
Immunoglobulin therapy ameliorates the phenotype and increases lifespan in the severely affected dystrophin-utrophin double knockout mice. / 12.2017 / PubMed / Full text
The experience of parents of adult sons with Duchenne muscular dystrophy regarding their prolonged roles as primary caregivers: a serial qualitative study. / 04.2019 / PubMed / Full text
Spatial and age-related changes in the microstructure of dystrophic and healthy diaphragms. / 2017 / PubMed / Full text
Growing patients with Duchenne muscular dystrophy: longitudinal changes in their dentofacial morphology and orofacial functional capacities. / 06.04.2018 / PubMed / Full text
Impaired regenerative capacity and lower revertant fibre expansion in dystrophin-deficient mdx muscles on DBA/2 background. / 07.12.2016 / PubMed / Full text
Use of the six-minute walk test to characterize golden retriever muscular dystrophy. / 12.2016 / PubMed / Full text
Small Fractions of Muscular Dystrophy Embryonic Stem Cells Yield Severe Cardiac and Skeletal Muscle Defects in Adult Mouse Chimeras. / 03.2017 / PubMed / Full text
Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy. / 16.09.2016 / PubMed / Full text
Dystrophin-Deficient Cardiomyopathy. / 31.05.2016 / PubMed / Full text
Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice. / 08.2016 / PubMed / Full text
Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease. / 05.2016 / PubMed / Full text
Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy. / 12.2015 / PubMed / Full text
Gastrocnemius medialis muscle architecture and physiological cross sectional area in adult males with Duchenne muscular dystrophy. / 06.2015 / PubMed / Full text
G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy. / 13.04.2015 / PubMed / Full text
Lack of dystrophin protein Dp71 results in progressive cataract formation due to loss of fiber cell organization. / 2014 / PubMed / Full text
Age-dependent changes in diastolic Ca(2 ) and Na( ) concentrations in dystrophic cardiomyopathy: Role of Ca(2 ) entry and IP3. / 03.10.2014 / PubMed / Full text
Transitioning to adulthood with a progressive condition: best practice assumptions and individual experiences of young men with Duchenne muscular dystrophy. / 2015 / PubMed / Full text
Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients. / 15.12.2014 / PubMed / Full text
Notch signaling deficiency underlies age-dependent depletion of satellite cells in muscular dystrophy. / 08.2014 / PubMed / Full text
Evolution of life expectancy of patients with Duchenne muscular dystrophy at AFM Yolaine de Kepper centre between 1981 and 2011. / 09.2013 / PubMed / Full text
Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle. / 01.11.2013 / PubMed / Full text
Digestive capacity in weanling and mature horses. / 05.2013 / PubMed / Full text
Insights into skeletal muscle development and applications in regenerative medicine. / 2013 / PubMed / Full text

FGF23[править]

Phosphate as a Pathogen of Arteriosclerosis and Aging. / 08.10.2020 / PubMed / Full text
Plasma Soluble αKlotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults. / 01.05.2020 / PubMed / Full text
Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis. / 2020 / PubMed / Full text
Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model. / 10.02.2020 / PubMed / Full text
FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model. / 05.12.2019 / PubMed / Full text
Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats. / 11.2019 / PubMed / Full text
Muscle-bone crosstalk and potential therapies for sarco-osteoporosis. / 09.2019 / PubMed / Full text
Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome. / 08.2019 / PubMed / Full text
Genome-wide associations and detection of potential candidate genes for direct genetic and maternal genetic effects influencing dairy cattle body weight at different ages. / 06.02.2019 / PubMed / Full text
Age-Related Changes and Effects of Bisphosphonates on Bone Turnover and Disease Progression in Fibrous Dysplasia of Bone. / 04.2019 / PubMed / Full text
Kotho and aging. / 09.2016 / PubMed
The Klotho proteins in health and disease. / 01.2019 / PubMed / Full text
Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging. / 04.2019 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
New Insights into the Mechanism of Action of Soluble Klotho. / 2017 / PubMed / Full text
The relevance of α-KLOTHO to the central nervous system: Some key questions. / 07.2017 / PubMed / Full text
Fibroblast Growth Factor 23 and the Risk of Infection-Related Hospitalization in Older Adults. / 04.2017 / PubMed / Full text
Reduction of calprotectin and phosphate during testosterone therapy in aging men: a randomized controlled trial. / 05.2017 / PubMed / Full text
Association between circulating fibroblast growth factor-23 and age-related cardiovascular-renal parameters in a healthy Chinese population. / 08.2017 / PubMed / Full text
The FGF23/KLOTHO Regulatory Network and Its Roles in Human Disorders. / 2016 / PubMed / Full text
Wound healing delays in α-Klotho-deficient mice that have skin appearance similar to that in aged humans - Study of delayed wound healing mechanism. / 13.05.2016 / PubMed / Full text
Partial Reversal of Tissue Calcification and Extension of Life Span following Ammonium Nitrate Treatment of Klotho-Deficient Mice. / 2016 / PubMed / Full text
[Regulatory mechanism of circulating inorganic phosphate]. / 02.2016 / PubMed / Full text
Biological Role of Anti-aging Protein Klotho. / 03.2015 / PubMed / Full text
Soluble αKlotho as a candidate for the biomarker of aging. / 27.11.2015 / PubMed / Full text
Acetazolamide sensitive tissue calcification and aging of klotho-hypomorphic mice. / 01.2016 / PubMed / Full text
N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models. / 2015 / PubMed / Full text
Intracellular signaling of the aging suppressor protein Klotho. / 2015 / PubMed / Full text
Tumour-associated osteomalacia and hypoglycaemia in a patient with prostate cancer: is Klotho involved? / 17.11.2014 / PubMed / Full text
Calpain 1 inhibitor BDA-410 ameliorates α-klotho-deficiency phenotypes resembling human aging-related syndromes. / 01.08.2014 / PubMed / Full text
[Bone metabolism and cardiovascular function update. α-klotho/FGF23 system; a new insight into the field of mineral homeostasis and the pathogeneses of aging-associated syndromes and the complications of chronic kidney disease]. / 07.2014 / PubMed / Full text
[Aging and inflammation: Klotho, diet and the kidney connection]. / 2012 / PubMed
Significance of the anti-aging protein Klotho. / 12.2013 / PubMed / Full text
FGF23 affects the lineage fate determination of mesenchymal stem cells. / 12.2013 / PubMed / Full text
Klotho and chronic kidney disease. / 2013 / PubMed / Full text

BRCA1[править]

Babam2 Regulates Cell Cycle Progression and Pluripotency in Mouse Embryonic Stem Cells as Revealed by Induced DNA Damage. / 10.10.2020 / PubMed / Full text
Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate. / 03.2020 / PubMed / Full text
BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging. / 01.01.2020 / PubMed / Full text
The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage. / 03.12.2019 / PubMed / Full text
Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study. / 25.11.2019 / PubMed / Full text
53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. / 02.01.2020 / PubMed / Full text
Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength. / 10.2019 / PubMed / Full text
PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair. / 06.2019 / PubMed / Full text
Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. / 2019 / PubMed / Full text
Klotho gene polymorphisms are associated with healthy aging and longevity: Evidence from a meta-analysis. / 03.2019 / PubMed / Full text
High expression of the breast cancer susceptibility gene BRCA1 in long-lived termite kings. / 11.10.2018 / PubMed / Full text
The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. / 2018 / PubMed / Full text
Cost effectiveness of population based BRCA1 founder mutation testing in Sephardi Jewish women. / 04.2018 / PubMed / Full text
Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions. / 04.01.2018 / PubMed / Full text
Faulty BRCA1, BRCA2 genes: how poor is the prognosis? / 10.2017 / PubMed / Full text
Ovarian Aging in Women With BRCA Germline Mutations. / 01.10.2017 / PubMed / Full text
The expected benefit of preventive mastectomy on breast cancer incidence and mortality in BRCA mutation carriers, by age at mastectomy. / 01.2018 / PubMed / Full text
A BRCA1-Dependent DNA Damage Response in the Regenerating Adult Peripheral Nerve Milieu. / 05.2018 / PubMed / Full text
The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate. / 30.05.2017 / PubMed / Full text
A Multigene Test Could Cost-Effectively Help Extend Life Expectancy for Women at Risk of Hereditary Breast Cancer. / 04.2017 / PubMed / Full text
Serum AMH levels in healthy women from BRCA1/2 mutated families: are they reduced? / 11.2016 / PubMed / Full text
p16INK4a suppresses BRCA1-deficient mammary tumorigenesis. / 20.12.2016 / PubMed / Full text
BRCA-1 Gene Expression and Comparative Proteomic Profile of Primordial Follicles from Young and Adult Buffalo (Bubalus bubalis) Ovaries. / 03.04.2017 / PubMed / Full text
Women's preferences for contralateral prophylactic mastectomy: An investigation using protection motivation theory. / 05.2016 / PubMed / Full text
Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome. / 15.03.2016 / PubMed / Full text
Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development. / 04.03.2016 / PubMed / Full text
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. / 11.2015 / PubMed / Full text
Comparative proteomic analysis of primordial follicles from ovaries of immature and aged rats. / 2015 / PubMed / Full text
BRCA Mutations, DNA Repair Deficiency, and Ovarian Aging. / 09.2015 / PubMed / Full text
Increased DNA damage and repair deficiency in granulosa cells are associated with ovarian aging in rhesus monkey. / 07.2015 / PubMed / Full text
Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells. / 06.2015 / PubMed / Full text
Molecular adaptation of telomere associated genes in mammals. / 15.11.2013 / PubMed / Full text
Copy neutral loss of heterozygosity is more frequent in older ovarian cancer patients. / 09.2013 / PubMed / Full text
Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans. / 13.02.2013 / PubMed / Full text

HMGB1[править]

A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma. / 13.10.2020 / PubMed / Full text
Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists. / 2020 / PubMed / Full text
Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release. / 26.11.2019 / PubMed / Full text
Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice. / 15.12.2019 / PubMed / Full text
Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction. / 02.12.2019 / PubMed / Full text
Senescence-induced immunophenotype, gene expression and electrophysiology changes in human amniocytes. / 11.2019 / PubMed / Full text
Targeting HMGB1 by ethyl pyruvate ameliorates systemic lupus erythematosus and reverses the senescent phenotype of bone marrow-mesenchymal stem cells. / 14.07.2019 / PubMed / Full text
HMGB1 and Caveolin-1 related to RPE cell senescence in age-related macular degeneration. / 07.07.2019 / PubMed / Full text
Dual faced HMGB1 plays multiple roles in cardiomyocyte senescence and cardiac inflammatory injury. / 06.2019 / PubMed / Full text
Neuroprotective Effect of Dioscin on the Aging Brain. / 30.03.2019 / PubMed / Full text
Modulation of soluble receptor for advanced glycation end-products (RAGE) isoforms and their ligands in healthy aging. / 23.03.2019 / PubMed / Full text
Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis. / 30.04.2019 / PubMed / Full text
Serum and nutrient deprivation increase autophagic flux in intervertebral disc annulus fibrosus cells: an in vitro experimental study. / 05.2019 / PubMed / Full text
Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. / 01.05.2019 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
Repeated abortion in adulthood induces cognition impairment in aged mice. / 30.07.2018 / PubMed / Full text
Loss of DNA polymerase β induces cellular senescence. / 08.2018 / PubMed / Full text
Nicotine-Induced Neuroprotection against Cognitive Dysfunction after Partial Hepatectomy Involves Activation of BDNF/TrkB Signaling Pathway and Inhibition of NF-κB Signaling Pathway in Aged Rats. / 06.03.2018 / PubMed / Full text
Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging. / 01.09.2017 / PubMed / Full text
Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging. / 06.2017 / PubMed / Full text
Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women. / 08.2017 / PubMed / Full text
Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats. / 2016 / PubMed / Full text
The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming. / 27.07.2016 / PubMed / Full text
Human fetal membranes at term: Dead tissue or signalers of parturition? / 08.2016 / PubMed / Full text
Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice. / 2016 / PubMed / Full text
DAMPs and influenza virus infection in ageing. / 11.2015 / PubMed / Full text
Decreased serum level of HMGB1 and MyD88 during human aging progress in healthy individuals. / 04.2016 / PubMed / Full text
[Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data]. / 2014 / PubMed
HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice. / 01.2015 / PubMed / Full text
Secondhand smoke exposure-induced nucleocytoplasmic shuttling of HMGB1 in a rat premature skin aging model. / 02.01.2015 / PubMed / Full text
Changes in the expression of the Toll-like receptor system in the aging rat kidneys. / 2014 / PubMed / Full text
Brain innate immunity in the regulation of neuroinflammation: therapeutic strategies by modulating CD200-CD200R interaction involve the cannabinoid system. / 2014 / PubMed / Full text
Postoperative impairment of cognitive function in old mice: a possible role for neuroinflammation mediated by HMGB1, S100B, and RAGE. / 12.2013 / PubMed / Full text
Neuroprotective effects of anti-high-mobility group box 1 antibody in juvenile rat hippocampus after kainic acid-induced status epilepticus. / 02.10.2013 / PubMed / Full text

NPY[править]

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells. / 22.05.2020 / PubMed / Full text
Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer. / 01.05.2020 / PubMed / Full text
Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice. / 03.2020 / PubMed / Full text
Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins. / 01.2020 / PubMed / Full text
Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner. / 21.03.2019 / PubMed / Full text
β-Alanine supplementation reduces anxiety and increases neurotrophin expression in both young and older rats. / 02.2019 / PubMed / Full text
Age-related central regulation of orexin and NPY in the short-lived African killifish Nothobranchius furzeri. / 15.05.2019 / PubMed / Full text
Chronic treatment with tributyltin induces sexually dimorphic alterations in the hypothalamic POMC system of adult mice. / 12.2018 / PubMed / Full text
Expression of CGRP neurotransmitter and vascular genesis marker mRNA is age-dependent in superior cervical ganglia of senescence-accelerated prone mice. / 18.01.2018 / PubMed / Full text
Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway. / 01.2018 / PubMed / Full text
Bioactive growth hormone in older men and women: It's relationship to immune markers and healthspan. / 06.2017 / PubMed / Full text
Retinal, NPY- and 5ht- inputs to the aged suprachiasmatic nucleus in common marmosets (Callithrix jacchus). / 08.2017 / PubMed / Full text
Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis. / 01.03.2017 / PubMed / Full text
Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: a trait potential for the life-extending effect of calorie restriction. / 04.2017 / PubMed / Full text
Nerve growth factor-induced plasticity in medial prefrontal cortex interneurons of aged Wistar rats. / 01.12.2016 / PubMed / Full text
Age Impaired endothelium-dependent vasodilation is improved by resveratrol in rat mesenteric arteries. / 31.03.2016 / PubMed / Full text
Age-related changes in neurochemical components and retinal projections of rat intergeniculate leaflet. / 02.2016 / PubMed / Full text
Short photoperiod condition increases susceptibility to stress in adolescent male rats. / 01.03.2016 / PubMed / Full text
Neuropeptide Y: An Anti-Aging Player? / 11.2015 / PubMed / Full text
Influence of Aging and Gender Differences on Feeding Behavior and Ghrelin-Related Factors during Social Isolation in Mice. / 2015 / PubMed / Full text
Reduction in NPY-positive neurons and dysregulation of excitability in young senescence-accelerated mouse prone 8 (SAMP8) hippocampus precede the onset of cognitive impairment. / 10.2015 / PubMed / Full text
Age effects on the nucleus of the lateral olfactory tract of the rat. / 01.03.2016 / PubMed / Full text
NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging? / 2015 / PubMed / Full text
Analysis of gene expression during aging of CGNs in culture: implication of SLIT2 and NPY in senescence. / 06.2015 / PubMed / Full text
Neuropeptide Y stimulates autophagy in hypothalamic neurons. / 31.03.2015 / PubMed / Full text
Effect of IP3R3 and NPY on age-related declines in olfactory stem cell proliferation. / 02.2015 / PubMed / Full text
Old-onset caloric restriction effects on neuropeptide Y- and somatostatin-containing neurons and on cholinergic varicosities in the rat hippocampal formation. / 2014 / PubMed / Full text
Orally administered δ opioid agonist peptide rubiscolin-6 stimulates food intake in aged mice with ghrelin resistance. / 10.2014 / PubMed / Full text
Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake. / 09.2014 / PubMed / Full text
Distribution of peptidergic populations in the human dentate gyrus (somatostatin [SOM-28, SOM-12] and neuropeptide Y [[[NPY]]]) during postnatal development. / 10.2014 / PubMed / Full text
Relative contribution of foetal and post-natal nutritional periods on feeding regulation in adult rats. / 01.2014 / PubMed / Full text
Early life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats. / 2013 / PubMed / Full text
Nerve growth factor retrieves neuropeptide Y and cholinergic immunoreactivity in the nucleus accumbens of old rats. / 08.2013 / PubMed / Full text
Aging and long-term caloric restriction regulate neuropeptide Y receptor subtype densities in the rat brain. / 06.2013 / PubMed / Full text

WRN[править]

The Impact of Vitamin C on Different System Models of Werner Syndrome. / 17.11.2020 / PubMed / Full text
WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells. / 14.10.2020 / PubMed / Full text
MIB1-mediated degradation of WRN promotes cellular senescence in response to camptothecin treatment. / 09.2020 / PubMed / Full text
A Case Report of Werner's Syndrome With a Novel Mutation From India. / 08.05.2020 / PubMed / Full text
Evidence for premature aging in a Drosophila model of Werner syndrome. / 11.2019 / PubMed / Full text
Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes. / 10.2019 / PubMed / Full text
Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases. / 06.2019 / PubMed / Full text
Werner Syndrome Protein and DNA Replication. / 02.11.2018 / PubMed / Full text
A case report of Werner's syndrome with bilateral juvenile cataracts. / 14.08.2018 / PubMed / Full text
Genomic instability and DNA replication defects in progeroid syndromes. / 31.12.2018 / PubMed / Full text
Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome. / 10.2018 / PubMed / Full text
Acidic domain of WRNp is critical for autophagy and up-regulates age associated proteins. / 08.2018 / PubMed / Full text
RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting. / 07.2018 / PubMed / Full text
Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. / 04.2018 / PubMed / Full text
Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein. / 07.2018 / PubMed / Full text
Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases. / 01.2018 / PubMed / Full text
Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells. / 28.01.2018 / PubMed / Full text
Recent Advances in Understanding Werner Syndrome. / 2017 / PubMed / Full text
Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. / 19.09.2017 / PubMed / Full text
The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase δ Elongation. / 01.02.2017 / PubMed / Full text
Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. / 07.2016 / PubMed / Full text
Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases. / 01.2017 / PubMed / Full text
Understanding Vascular Diseases: Lessons From Premature Aging Syndromes. / 05.2016 / PubMed / Full text
Stem Cell Depletion by Global Disorganization of the H3K9me3 Epigenetic Marker in Aging. / 08.2015 / PubMed / Full text
The Werner Protein Acts as a Coactivator of Nuclear Factor κB (NF-κB) on HIV-1 and Interleukin-8 (IL-8) Promoters. / 24.07.2015 / PubMed / Full text
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. / 05.06.2015 / PubMed / Full text
Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming. / 2015 / PubMed / Full text
Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells. / 12.2014 / PubMed / Full text
Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice. / 15.05.2014 / PubMed / Full text
Search and insights into novel genetic alterations leading to classical and atypical Werner syndrome. / 2014 / PubMed / Full text
Hydrogen sulfide restores a normal morphological phenotype in Werner syndrome fibroblasts, attenuates oxidative damage and modulates mTOR pathway. / 08.2013 / PubMed / Full text
Copy number variations of DNA repair genes and the age-related cataract: Jiangsu Eye Study. / 01.02.2013 / PubMed / Full text
The associations between single nucleotide polymorphisms of DNA repair genes, DNA damage, and age-related cataract: Jiangsu Eye Study. / 01.02.2013 / PubMed / Full text
Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome. / 01.2013 / PubMed / Full text

KL[править]

Alignment of Alzheimer's disease amyloid β-peptide and klotho. / 11-12.2020 / PubMed / Full text
PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation. / 07.2020 / PubMed / Full text
Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells. / 05.2020 / PubMed / Full text
FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model. / 05.12.2019 / PubMed / Full text
The goddess who spins the thread of life: Klotho, psychiatric stress, and accelerated aging. / 08.2019 / PubMed / Full text
[i]KLOTHO[/i] heterozygosity attenuates [i]APOE4[/i]-related amyloid burden in preclinical AD. / 16.04.2019 / PubMed / Full text
Utilizing Atlas-Based Modeling to Predict Knee Joint Cartilage Degeneration: Data from the Osteoarthritis Initiative. / 03.2019 / PubMed / Full text
Impaired proteostasis in senescent vascular endothelial cells: a perspective on estrogen and oxidative stress in the aging vasculature. / 01.02.2019 / PubMed / Full text
Leukocyte Telomere Length in Patients with Radiographic Knee Osteoarthritis. / 04.2019 / PubMed / Full text
Klotho at the Edge of Alzheimer's Disease and Senile Depression. / 03.2019 / PubMed / Full text
Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity. / 10.2018 / PubMed / Full text
G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old. / 30.04.2018 / PubMed / Full text
Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling. / 2017 / PubMed / Full text
Changes in expression of klotho affect physiological processes, diseases, and cancer. / 01.2018 / PubMed / Full text
Anti-aging factor, serum alpha-Klotho, as a marker of acute physiological stress, and a predictor of ICU mortality, in patients with septic shock. / 04.2018 / PubMed / Full text
Secreted αKlotho isoform protects against age-dependent memory deficits. / 09.2018 / PubMed / Full text
Induction of anti-aging gene klotho with a small chemical compound that demethylates CpG islands. / 18.07.2017 / PubMed / Full text
Longevity Klotho gene polymorphism and the risk of dementia in older men. / 07.2017 / PubMed / Full text
Klotho, APOEε4, cognitive ability, brain size, atrophy, and survival: a study in the Aberdeen Birth Cohort of 1936. / 07.2017 / PubMed / Full text
The relevance of α-KLOTHO to the central nervous system: Some key questions. / 07.2017 / PubMed / Full text
Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging. / 04.2017 / PubMed / Full text
Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity. / 11.2016 / PubMed / Full text
The FGF23/KLOTHO Regulatory Network and Its Roles in Human Disorders. / 2016 / PubMed / Full text
Antiaging Gene Klotho Deficiency Promoted High-Fat Diet-Induced Arterial Stiffening via Inactivation of AMP-Activated Protein Kinase. / 03.2016 / PubMed / Full text
KL-optimal experimental design for discriminating between two growth models applied to a beef farm. / 02.2016 / PubMed / Full text
Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression. / 2015 / PubMed / Full text
Genetic Variants in KLOTHO Associate With Cognitive Function in the Oldest Old Group. / 09.2016 / PubMed / Full text
Molecular basis of Klotho: from gene to function in aging. / 04.2015 / PubMed / Full text
Life extension factor klotho enhances cognition. / 22.05.2014 / PubMed / Full text
Quadriceps intramuscular fat fraction rather than muscle size is associated with knee osteoarthritis. / 02.2014 / PubMed / Full text
Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk. / 20.12.2013 / PubMed / Full text
Association of Klotho polymorphisms with healthy aging: a systematic review and meta-analysis. / 04.2014 / PubMed / Full text
Serum KL-6 concentrations are associated with molecular sizes and efflux behavior of KL-6/MUC1 in healthy subjects. / 23.09.2013 / PubMed / Full text

SIRT2[править]

NAD Repletion Rescues Female Fertility during Reproductive Aging. / 11.02.2020 / PubMed / Full text
Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the SIRT2-dependent H4K16 deacetylation pathway. / 24.01.2020 / PubMed / Full text
Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet. / 2019 / PubMed / Full text
SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes. / 01.09.2019 / PubMed / Full text
Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion. / 2019 / PubMed / Full text
Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging. / 22.01.2019 / PubMed / Full text
Hsp90 Stabilizes SIRT1 Orthologs in Mammalian Cells and [i]C. elegans[/i]. / 20.11.2018 / PubMed / Full text
Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes. / 01.05.2019 / PubMed / Full text
High expression of CPT1b in skeletal muscle in metabolically healthy older subjects. / 04.2019 / PubMed / Full text
Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans. / 2017 / PubMed / Full text
Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance. / 12.2017 / PubMed / Full text
SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy. / 21.11.2017 / PubMed / Full text
Molecular evolutionary patterns of NAD /Sirtuin aging signaling pathway across taxa. / 2017 / PubMed / Full text
Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders. / 03.2017 / PubMed / Full text
Resistance training and redox homeostasis: Correlation with age-associated genomic changes. / 12.2016 / PubMed / Full text
Aging-related 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurochemial and behavioral deficits and redox dysfunction: improvement by AK-7. / 09.2016 / PubMed / Full text
Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status. / 17.07.2016 / PubMed / Full text
Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins. / 15.06.2016 / PubMed / Full text
Sirtuins, Cell Senescence, and Vascular Aging. / 05.2016 / PubMed / Full text
The expression levels of the sirtuins in patients with BCC. / 05.2016 / PubMed / Full text
Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum. / 11.2015 / PubMed / Full text
Localization of sirtuins (SIRT1-7) in the aged mouse inner ear. / 2016 / PubMed / Full text
Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7. / 2015 / PubMed / Full text
Differential expression of sirtuins in the aging rat brain. / 2015 / PubMed / Full text
Polymorphisms Falling Within Putative miRNA Target Sites in the 3'UTR Region of SIRT2 and DRD2 Genes Are Correlated With Human Longevity. / 05.2016 / PubMed / Full text
The role of melatonin, sirtuin2 and FoXO1 transcription factor in the aging process of colon in male rats. / 02.2015 / PubMed / Full text
[[[SIRT2]], a multi-talented deacetylase]. / 05.2014 / PubMed / Full text
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. / 01.07.2014 / PubMed / Full text
Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. / 06.09.2013 / PubMed / Full text
Dietary restriction increases protein acetylation in the livers of aged rats. / 2013 / PubMed / Full text
Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice. / 15.11.2013 / PubMed / Full text
Growth hormone and melatonin prevent age-related alteration in apoptosis processes in the dentate gyrus of male rats. / 08.2013 / PubMed / Full text

TFAM[править]

Effect of aging on mitochondria and metabolism of bovine granulosa cells. / 13.09.2020 / PubMed / Full text
Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults. / 08.2020 / PubMed / Full text
Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21 -PKCζ pathway in p16 -silenced cells. / 24.04.2020 / PubMed / Full text
Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. / 01.10.2019 / PubMed / Full text
Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats. / 27.05.2019 / PubMed / Full text
Photobiomodulation and Coenzyme Q Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice. / 2019 / PubMed / Full text
[A study on alterations in mitochondrial biological characteristics during cellular senescence of human embryonic lung fibroblasts]. / 06.03.2019 / PubMed / Full text
Changes in Stemness Properties, Differentiation Potential, Oxidative Stress, Senescence and Mitochondrial Function in Wharton's Jelly Stem Cells of Umbilical Cords of Mothers with Gestational Diabetes Mellitus. / 06.2019 / PubMed / Full text
Cycling CD4 T cells in HIV-infected immune nonresponders have mitochondrial dysfunction. / 01.11.2018 / PubMed / Full text
Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart. / 20.08.2018 / PubMed / Full text
Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice. / 08.2018 / PubMed / Full text
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway. / 02.2018 / PubMed / Full text
Skeletal muscle from aged American Quarter Horses shows impairments in mitochondrial biogenesis and expression of autophagy markers. / 02.2018 / PubMed / Full text
Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats. / 11.2017 / PubMed / Full text
Effect of lifelong football training on the expression of muscle molecular markers involved in healthy longevity. / 04.2017 / PubMed / Full text
Regulation of mitochondrial gene expression, the epigenetic enigma. / 01.03.2017 / PubMed / Full text
Poor embryo development in post-ovulatory in vivo-aged mouse oocytes is associated with mitochondrial dysfunction, but mitochondrial transfer from somatic cells is not sufficient for rejuvenation. / 10.2016 / PubMed / Full text
Disentangling the effect of dietary restriction on mitochondrial function using recombinant inbred mice. / 05.11.2017 / PubMed / Full text
"What makes some rats live so long?" The mitochondrial contribution to longevity through balance of mitochondrial dynamics and mtDNA content. / 01.12.2016 / PubMed / Full text
Response of BAX, Bcl-2 Proteins, and SIRT1/PGC-1α mRNA Expression to 8-Week Treadmill Running in the Aging Rat Skeletal Muscle. / 2016 / PubMed / Full text
Methylene blue improves sensorimotor phenotype and decreases anxiety in parallel with activating brain mitochondria biogenesis in mid-age mice. / 12.2016 / PubMed / Full text
HIF-1 regulates insect lifespan extension by inhibiting c-Myc-TFAM signaling and mitochondrial biogenesis. / 11.2016 / PubMed / Full text
Resistance exercise training and in vitro skeletal muscle oxidative capacity in older adults. / 07.2016 / PubMed / Full text
Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders. / 11.2016 / PubMed / Full text
Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. / 2016 / PubMed
Regulation of mitochondrial biogenesis through TFAM-mitochondrial DNA interactions: Useful insights from aging and calorie restriction studies. / 11.2015 / PubMed / Full text
Dietary Tocotrienol/γ-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice. / 2015 / PubMed / Full text
A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat. / 07.2014 / PubMed / Full text
Partial reversal of skeletal muscle aging by restoration of normal NAD⁺ levels. / 02.2014 / PubMed / Full text
Aging and calorie restriction oppositely affect mitochondrial biogenesis through TFAM binding at both origins of mitochondrial DNA replication in rat liver. / 2013 / PubMed / Full text

ATF4[править]

Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78-Loaded Extracellular Vesicles. / 10.12.2020 / PubMed / Full text
Verification of Resveratrol Inhibits Intestinal Aging by Downregulating ATF4/Chop/Bcl-2/Bax Signaling Pathway: Based on Network Pharmacology and Animal Experiment. / 2020 / PubMed / Full text
Decline in testicular function in ageing rats: Changes in the unfolded protein response and mitochondrial apoptotic pathway. / 11.2019 / PubMed / Full text
Extracellular acidosis triggers a senescence-like phenotype in human melanoma cells. / 01.2020 / PubMed / Full text
Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis. / 06.2019 / PubMed / Full text
Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. / 08.2019 / PubMed / Full text
Effects of a resistance-training programme on endoplasmic reticulum unfolded protein response and mitochondrial functions in PBMCs from elderly subjects. / 08.2019 / PubMed / Full text
[Protective effect of Wuzi Yanzong recipe on testicular germ cell apoptosis in natural ageing rats through endoplasmic reticulum stress]. / 10.2018 / PubMed / Full text
Protective effect of Wuzi Yanzong recipe on testicular dysfunction through inhibition of germ cell apoptosis in ageing rats via endoplasmic reticulum stress. / 03.2019 / PubMed / Full text
Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration. / 01.2019 / PubMed / Full text
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text
De-silencing [i]Grb10[/i] contributes to acute ER stress-induced steatosis in mouse liver. / 05.2018 / PubMed / Full text
Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain. / 02.2018 / PubMed / Full text
Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity. / 12.2017 / PubMed / Full text
Role of ATF4 in skeletal muscle atrophy. / 05.2017 / PubMed / Full text
4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging. / 02.01.2017 / PubMed / Full text
Diaminodiphenyl sulfone-induced parkin ameliorates age-dependent dopaminergic neuronal loss. / 05.2016 / PubMed / Full text
Different Roles of Negative and Positive Components of the Circadian Clock in Oncogene-induced Neoplastic Transformation. / 13.05.2016 / PubMed / Full text
Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice. / 15.01.2016 / PubMed / Full text
Unfolded protein response is activated in aged retinas. / 16.11.2015 / PubMed / Full text
Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. / 16.10.2015 / PubMed / Full text
Effect of mitochondrial stress on systemic metabolism. / 09.2015 / PubMed / Full text
Senescence may mediate conversion of tau phosphorylation-induced apoptotic escape to neurodegeneration. / 08.2015 / PubMed / Full text
Impact of ER stress-regulated ATF4/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy. / 15.04.2015 / PubMed / Full text
ATF4 activity: a common feature shared by many kinds of slow-aging mice. / 12.2014 / PubMed / Full text
The unfolded protein response is triggered following a single, unaccustomed resistance-exercise bout. / 15.09.2014 / PubMed / Full text
Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21. / 10.2014 / PubMed / Full text
The first international mini-symposium on methionine restriction and lifespan. / 2014 / PubMed / Full text
Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice. / 03.2015 / PubMed / Full text
Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry. / 03.2014 / PubMed / Full text

CDKN2A[править]

Association between Nrf2 and [[CDKN2A]] expression in patients with end-stage renal disease: a pilot study. / 13.07.2020 / PubMed / Full text
Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†. / 23.06.2020 / PubMed / Full text
Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts. / 01.2020 / PubMed / Full text
Astrocyte senescence may drive alterations in GFAPα, [[CDKN2A]] p14 , and TAU3 transcript expression and contribute to cognitive decline. / 10.2019 / PubMed / Full text
Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts. / 12.2019 / PubMed / Full text
Analysis of the putative tumor suppressor gene cdkn2ab in pigment cells and melanoma of Xiphophorus and medaka. / 03.2019 / PubMed / Full text
In vitro behavior and UV response of melanocytes derived from carriers of [[CDKN2A]] mutations and MC1R variants. / 03.2019 / PubMed / Full text
Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Is Essential for Preventing Endothelial Dysfunction With Aging. / 07.2018 / PubMed / Full text
Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16 inactivation. / 26.02.2018 / PubMed / Full text
Cellular aging dynamics after acute malaria infection: A 12-month longitudinal study. / 02.2018 / PubMed / Full text
ARID1A suppresses malignant transformation of human pancreatic cells via mediating senescence-associated miR-503/[[CDKN2A]] regulatory axis. / 18.11.2017 / PubMed / Full text
Cellular Senescence in Mouse Hippocampus After Irradiation and the Role of p53 and p21. / 01.04.2017 / PubMed / Full text
Identification of the activating cytotoxicity receptor NKG2D as a senescence marker in zero-hour kidney biopsies is indicative for clinical outcome. / 06.2017 / PubMed / Full text
ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A. / 24.03.2017 / PubMed / Full text
Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing. / 14.02.2017 / PubMed / Full text
Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus. / 18.05.2016 / PubMed / Full text
Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts. / 11-12.2015 / PubMed / Full text
Alterations of telomere length and DNA methylation in hairdressers: A cross-sectional study. / 03.2016 / PubMed / Full text
Genetics of melanoma progression: the rise and fall of cell senescence. / 03.2016 / PubMed / Full text
Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis. / 02.11.2015 / PubMed / Full text
Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium. / 06.2015 / PubMed / Full text
Y-27632, a ROCK inhibitor, delays senescence of putative murine salivary gland stem cells in culture. / 06.2015 / PubMed / Full text
Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. / 29.05.2014 / PubMed / Full text
Nodes and biological processes identified on the basis of network analysis in the brain of the senescence accelerated mice as an Alzheimer's disease animal model. / 2013 / PubMed / Full text
Id4 promotes senescence and sensitivity to doxorubicin-induced apoptosis in DU145 prostate cancer cells. / 10.2013 / PubMed / Full text
Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing. / 09.2013 / PubMed / Full text
CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion. / 15.09.2013 / PubMed / Full text
Accelerated biological ageing in HIV-infected individuals in South Africa: a case-control study. / 24.09.2013 / PubMed / Full text
Assessment of candidate ocular biomarkers of ageing in a South African adult population: relationship with chronological age and systemic biomarkers. / 07-08.2013 / PubMed / Full text
Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes. / 15.08.2013 / PubMed / Full text

COMT[править]

Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan. / 11.11.2020 / PubMed / Full text
The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain. / 05.2020 / PubMed / Full text
A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study. / 05.2019 / PubMed / Full text
Frontoparietal cortical thickness mediates the effect of COMT Val Met polymorphism on age-associated executive function. / 01.2019 / PubMed / Full text
[MELATONIN: THE POSSIBILITY TO ANALYSE THE MARKER OF AGE-RELATED PATHOLOGY IN THE BUCCAL EPITHELIUM AND URINE]. / 2017 / PubMed
The Moderating Role of COMT and BDNF Polymorphisms on Transfer Effects Following Multi- and Single-Domain Cognitive Training Among Community-Dwelling Shanghainese Older Adults. / 2018 / PubMed / Full text
Genetic Risk for Age-Related Cognitive Impairment Does Not Predict Cognitive Performance in Middle Age. / 2018 / PubMed / Full text
Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study. / 07.2018 / PubMed / Full text
Genetic Biomarkers on Age-Related Cognitive Decline. / 2017 / PubMed / Full text
A genetic variant in the catechol-O-methyl transferase (COMT) gene is related to age-dependent differences in the therapeutic effect of calcium-channel blockers. / 07.2017 / PubMed / Full text
Catechol-O-Methyltransferase Genotype and Gait Speed Changes over 10 Years in Older Adults. / 09.2017 / PubMed / Full text
[Melatonin as a molecular marker of age-related pathologies]. / 2017 / PubMed
Chloroplast overexpression of rice caffeic acid O-methyltransferase increases melatonin production in chloroplasts via the 5-methoxytryptamine pathway in transgenic rice plants. / 08.2017 / PubMed / Full text
Age-dependent role of pre- and perinatal factors in interaction with genes on ADHD symptoms across adolescence. / 07.2017 / PubMed / Full text
Age differences in arterial and venous extra-cerebral blood flow in healthy adults: contributions of vascular risk factors and genetic variants. / 08.2017 / PubMed / Full text
Executive function performance and change in aging is predicted by apolipoprotein E, intensified by catechol-O-methyltransferase and brain-derived neurotrophic factor, and moderated by age and lifestyle. / 04.2017 / PubMed / Full text
Age-Dependent Effects of Catechol-O-Methyltransferase (COMT) Gene Val158Met Polymorphism on Language Function in Developing Children. / 01.01.2017 / PubMed / Full text
Aging and the genetic road towards the positivity effect in memory. / 09.2016 / PubMed / Full text
Older age may offset genetic influence on affect: The COMT polymorphism and affective well-being across the life span. / 05.2016 / PubMed / Full text
Differential effect of age on posterior and anterior hippocampal functional connectivity. / 06.2016 / PubMed / Full text
Pulse Pressure Magnifies the Effect of COMT Val(158)Met on 15 Years Episodic Memory Trajectories. / 2016 / PubMed / Full text
Modulative effects of COMT haplotype on age-related associations with brain morphology. / 06.2016 / PubMed / Full text
COMT Val158Met polymorphism is associated with blood pressure and lipid levels in general families of Bama longevous area in China. / 2015 / PubMed / Full text
Genetic Basis of the Relationship Between Reproduction and Longevity: A Study on Common Variants of Three Genes in Steroid Hormone Metabolism--CYP17, HSD17B1, and COMT. / 10.2015 / PubMed / Full text
Cognitive ability, intraindividual variability, and common genetic variants of catechol-O-methyltransferase and brain-derived neurotrophic factor: a longitudinal study in a population-based sample of older adults. / 06.2014 / PubMed / Full text
Healthy aging increases the cognitive effects of two genes that influence extracellular dopamine. / 06.2014 / PubMed / Full text
BDNF and COMT polymorphisms have a limited association with episodic memory performance or engagement in complex cognitive activity in healthy older adults. / 04.2014 / PubMed / Full text
Age-related and genetic modulation of frontal cortex efficiency. / 04.2014 / PubMed / Full text
COMT polymorphism and memory dedifferentiation in old age. / 06.2014 / PubMed / Full text
Genetic effects on old-age cognitive functioning: a population-based study. / 03.2013 / PubMed / Full text

TLR2[править]

Changes in salivary microbial sensing proteins CD14 and TLR2 with aging. / 07.2020 / PubMed / Full text
Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits. / 02.2020 / PubMed / Full text
Culture Model for Non-human Primate Choroid Plexus. / 2019 / PubMed / Full text
Changes in fetal membrane histology with cervical insufficiency and transabdominal cerclage. / 08.2019 / PubMed / Full text
Aging leads to dysfunctional innate immune responses to TLR2 and TLR4 agonists. / 09.2019 / PubMed / Full text
The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson's Disease. / 10.2018 / PubMed / Full text
Aging modulates microglia phenotypes in neuroinflammation of MPTP-PD mice. / 01.10.2018 / PubMed / Full text
Toll-like receptor 2 deficiency hyperactivates the FoxO1 transcription factor and induces aging-associated cardiac dysfunction in mice. / 24.08.2018 / PubMed / Full text
Cryopreserved whole blood for the quantification of monocyte, T-cell and NK-cell subsets, and monocyte receptor expression by multi-color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging. / 05.2018 / PubMed / Full text
TLR4 and TLR2 activation is differentially associated with age during Parkinson's disease. / 01.2018 / PubMed / Full text
Role of pattern recognition receptors of the neurovascular unit in inflamm-aging. / 01.11.2017 / PubMed / Full text
Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence. / 04.2017 / PubMed / Full text
Aging-related Atg5 defect impairs neutrophil extracellular traps formation. / 08.2017 / PubMed / Full text
Chronoinflammaging in Alzheimer; A systematic review on the roles of toll like receptor 2. / 15.02.2017 / PubMed / Full text
Aged B cells alter immune regulation of allografts in mice. / 11.2016 / PubMed / Full text
Estrogen receptors alpha mediates postischemic inflammation in chronically estrogen-deprived mice. / 04.2016 / PubMed / Full text
Effects of aerobic training on markers of autophagy in the elderly. / 04.2016 / PubMed / Full text
Reduced levels of cytosolic DNA sensor AIM2 are associated with impaired cytokine responses in healthy elderly. / 06.2016 / PubMed / Full text
Immune ageing and susceptibility to Streptococcus pneumoniae. / 06.2016 / PubMed / Full text
Monocyte Phenotype and Polyfunctionality Are Associated With Elevated Soluble Inflammatory Markers, Cytomegalovirus Infection, and Functional and Cognitive Decline in Elderly Adults. / 05.2016 / PubMed / Full text
Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice. / 06.2015 / PubMed / Full text
Prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal TLR4 activation in aged rats. / 05.2015 / PubMed / Full text
Altered neutrophil functions in elderly patients during a 6-month follow-up period after a hip fracture. / 05.2015 / PubMed / Full text
Aging does not affect the ability of human monocyte-derived dendritic cells to phagocytose Candida albicans. / 12.2015 / PubMed / Full text
Cardiac autonomic dysfunction: particulate air pollution effects are modulated by epigenetic immunoregulation of Toll-like receptor 2 and dietary flavonoid intake. / 27.01.2015 / PubMed / Full text
Bacteria and Toll-like receptor and cytokine mRNA expression profiles associated with canine arthritis. / 15.08.2014 / PubMed / Full text
Innate immune activation in the pathogenesis of a murine model of globoid cell leukodystrophy. / 02.2014 / PubMed / Full text
Dendritic cells from the elderly display an intrinsic defect in the production of IL-10 in response to lithium chloride. / 11.2013 / PubMed / Full text
Hypothalamic neuronal toll-like receptor 2 protects against age-induced obesity. / 2013 / PubMed / Full text
Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age. / 15.02.2013 / PubMed / Full text

Aging genes 30-39

CCL2[править]

CD14[править]

CORT[править]

ATR[править]

CCK[править]

FOXO1[править]

MYC[править]

STS[править]

CD38[править]

CDK4[править]

EGFR[править]

BACE1[править]

LBP[править]

DMD[править]

FGF23[править]

BRCA1[править]

HMGB1[править]

NPY[править]

WRN[править]

KL[править]

SIRT2[править]

TFAM[править]

ATF4[править]

CDKN2A[править]

COMT[править]

TLR2[править]

Навигация