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Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11) [AGTRL1] [APJ]


Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects.

Treatment of type 2 diabetes mellitus continues to pose an important clinical challenge, with most existing therapies lacking demonstrable ability to improve cardiovascular outcomes. The atheroprotective peptide apelin (APLN) enhances glucose utilization and improves insulin sensitivity. However, the mechanism of these effects remains poorly defined. We demonstrate that the expression of APLNR (APJ/AGTRL1), the only known receptor for apelin, is predominantly restricted to the endothelial cells (ECs) of multiple adult metabolic organs, including skeletal muscle and adipose tissue. Conditional endothelial-specific deletion of [i]Aplnr[/i] ([i]Aplnr[/i] ) resulted in markedly impaired glucose utilization and abrogation of apelin-induced glucose lowering. Furthermore, we identified inactivation of Forkhead box protein O1 (FOXO1) and inhibition of endothelial expression of fatty acid (FA) binding protein 4 (FABP4) as key downstream signaling targets of apelin/APLNR signaling. Both the [i]Apln[/i] and [i]Aplnr[/i] mice demonstrated increased endothelial FABP4 expression and excess tissue FA accumulation, whereas concurrent endothelial [i]Foxo1[/i] deletion or pharmacologic FABP4 inhibition rescued the excess FA accumulation phenotype of the [i]Apln[/i] mice. The impaired glucose utilization in the [i]Aplnr[/i] mice was associated with excess FA accumulation in the skeletal muscle. Treatment of these mice with an FABP4 inhibitor abrogated these metabolic phenotypes. These findings provide mechanistic insights that could greatly expand the therapeutic repertoire for type 2 diabetes and related metabolic disorders.

MeSH Terms

  • Aging
  • Animals
  • Apelin
  • Apelin Receptors
  • Endothelium
  • Fatty Acid-Binding Proteins
  • Fatty Acids
  • Forkhead Box Protein O1
  • Glucose
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Male
  • Mice, Knockout
  • Signal Transduction