RGS5
Regulator of G-protein signaling 5 (RGS5)
Publications[править]
Regulators of G-protein signalling (RGS) are recently identified proteins that shorten the lifetime of the activated G protein. We now show that rat cardiac myocytes express mRNA for at least 10 RGS. The mRNA for RGS-r is barely detectable in rat ventricles, but increases more than 20-fold during the 60- to 90-min process of isolating ventricular myocytes, and after 90 min of culture of atrial pieces in medium with Ca2 . Both in myocytes and in atria, the rise in RGS-r is transient. The mRNA for cardiac RGS5, but not RGS-r, is developmentally regulated. These studies suggest that rapid regulation of RGS levels may be a new mechanism that governs how signals are transmitted across the cardiac cell membrane.
MeSH Terms
- Aging
- Animals
- Animals, Newborn
- Cell Membrane
- Cells, Cultured
- Eye Proteins
- GTP-Binding Proteins
- GTPase-Activating Proteins
- Gene Expression Regulation
- Heart
- Heart Atria
- Heart Ventricles
- Kinetics
- Myocardium
- Organ Specificity
- Protein Biosynthesis
- Proteins
- RGS Proteins
- RNA, Messenger
- Rats
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction
- Transcription, Genetic