PPP2R5C

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Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29) [KIAA0044]

Publications[править]

PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation.

The insulin/TOR signaling pathway plays a crucial role in animal homeostasis, sensing nutrient status to regulate organismal growth and metabolism. We identify here the Drosophila B' regulatory subunit of PP2A (PP2A-B') as a novel, conserved component of the insulin pathway that specifically targets the PP2A holoenzyme to dephosphorylate S6K. PP2A-B' knockout flies have elevated S6K phosphorylation and exhibit phenotypes typical of elevated insulin signaling such as reduced total body triglycerides and reduced longevity. We show that PP2A-B' interacts with S6K both physically and genetically. The human homolog of PP2A-B', PPP2R5C, also counteracts S6K1 phosphorylation, indicating a conserved mechanism in mammals. Since S6K affects development of cancer and metabolic disease, our data identify PPP2R5C as a novel factor of potential medical relevance.

MeSH Terms

  • Animals
  • Drosophila
  • Drosophila Proteins
  • Gene Knockout Techniques
  • Humans
  • Insulin
  • Longevity
  • Phosphoprotein Phosphatases
  • Phosphorylation
  • Protein Phosphatase 2
  • Ribosomal Protein S6 Kinases, 70-kDa
  • Signal Transduction
  • Triglycerides