NALCN

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Sodium leak channel non-selective protein (CanIon) (Voltage gated channel-like protein 1) [VGCNL1]

Publications[править]

A sodium leak current regulates pacemaker activity of adult central pattern generator neurons in Lymnaea stagnalis.

The resting membrane potential of the pacemaker neurons is one of the essential mechanisms underlying rhythm generation. In this study, we described the biophysical properties of an uncharacterized channel (U-type channel) and investigated the role of the channel in the rhythmic activity of a respiratory pacemaker neuron and the respiratory behaviour in adult freshwater snail Lymnaea stagnalis. Our results show that the channel conducts an inward leak current carried by Na( ) (I(Leak-Na)). The I(Leak-Na) contributed to the resting membrane potential and was required for maintaining rhythmic action potential bursting activity of the identified pacemaker RPeD1 neurons. Partial knockdown of the U-type channel suppressed the aerial respiratory behaviour of the adult snail in vivo. These findings identified the Na( ) leak conductance via the U-type channel, likely a NALCN-like channel, as one of the fundamental mechanisms regulating rhythm activity of pacemaker neurons and respiratory behaviour in adult animals.

MeSH Terms

  • Aging
  • Amino Acid Sequence
  • Animals
  • Behavior, Animal
  • Biological Clocks
  • Calcium
  • Cell Membrane
  • Cell Separation
  • Electricity
  • Extracellular Space
  • Gadolinium
  • Gene Knockdown Techniques
  • Ion Channel Gating
  • Lymnaea
  • Membrane Potentials
  • Molecular Sequence Data
  • Neurons
  • RNA, Double-Stranded
  • Sequence Alignment
  • Sodium Channels