FABP2
Fatty acid-binding protein, intestinal (Fatty acid-binding protein 2) (Intestinal-type fatty acid-binding protein) (I-FABP) [FABPI]
Publications[править]
The present study was performed to investigate the effects of the intestinal fatty acid-binding protein (FABP2) gene Ala54Thr polymorphism and the beta(3)-adrenergic receptor (beta3AR) gene Trp64Arg polymorphism on body mass index (BMI), blood pressure, heart rate, glucose and lipid profiles, and serum leptin level in 196 young men aged 21 to 39 years, 186 older normoglycemic men (fasting plasma glucose [FPG] < 110 mg/dL) aged 40 to 65 years, and 122 older hyperglycemic men, including 77 type 2 diabetic patients. Genomic DNA was extracted from the peripheral blood, and these polymorphisms were assessed by the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method. In the older groups, the beta3AR Arg64-allele frequency tended to be lower and the FABP2 Thr/Thr54 genotype frequency tended to be higher in hyperglycemic patients, although these differences did not reach statistical significance. Also, there were no significant differences in the genotype or allele frequency of either variant between the 27 hyperlipidemic and 204 normolipidemic subjects. In the younger group, there were no significant differences in any of the parameters measured between the genotypes of beta3AR or FABP2. In the older normoglycemic subjects, heart rate was significantly lower (P =.037) in beta3AR Arg64-positive subjects, and FPG was significantly higher in subjects with the FABP2 Thr/Thr genotype than the other genotypes (99.8 /- 5.6 v 96.5 /- 5.6 mg/dL, P =.010). In the older hyperglycemic group, the beta3AR Arg64-positive group had significantly lower high-density lipoprotein (HDL) cholesterol and free fatty acid (FFA) levels (P =.024 and P =.043, respectively). There were no synergistic effects of these 2 variants on any measured parameter, but only the FABP2 Thr/Thr genotype was related to a higher FPG in the older normoglycemic men. In conclusion, no major difference was associated with the beta3AR Trp64Arg or FABP2 Ala54Thr polymorphism in terms of type 2 diabetes or hyperlipidemia in young to older Japanese men. However, a slight but significant increase in FPG was observed in older Japanese men with the FABP2 Thr/Thr genotype.
MeSH Terms
- Adult
- Aged
- Aging
- Amino Acid Substitution
- Blood Glucose
- Blood Pressure
- Body Mass Index
- Carrier Proteins
- Fasting
- Fatty Acid-Binding Protein 7
- Fatty Acid-Binding Proteins
- Gene Frequency
- Genotype
- Humans
- Hyperglycemia
- Insulin Resistance
- Leptin
- Lipids
- Male
- Middle Aged
- Neoplasm Proteins
- Polymorphism, Genetic
- Receptors, Adrenergic, beta-3
- Tumor Suppressor Proteins
This study determined whether sequence variations in genes related to glucose and insulin metabolism are associated with insulin sensitivity in postmenopausal women after accounting for habitual physical activity levels, body composition, and hormone-replacement therapy (HRT). Eighteen sedentary, 19 physically active, and 23 athletic postmenopausal white women underwent a frequently sampled intravenous glucose tolerance test to determine insulin sensitivity (S(I)) and dual-energy x-ray absorptiometry to determine body composition. After accounting for the effects of body composition, habitual physical activity levels, and HRT status, S(I) was 26% lower in subjects with the Thr54 fatty acid-binding protein 2 (FABP2) allele compared with Ala54 homozygotes (4.3 /- 0.5 v 5.8 /- 0.6 microU x 10(-4)/min/mL; P <.05). Angiotensin-converting enzyme genotype was not significantly associated with S(I). There were no significant associations between Gln27Glu beta(2)-adrenergic receptor or Pro12Ala peroxisome proliferator-activated receptor gamma variants and glucose or insulin kinetic parameters. It was concluded that FABP2 genotype influences insulin sensitivity independent of body composition, habitual physical activity levels, and HRT status in postmenopausal white women.
MeSH Terms
- Absorptiometry, Photon
- Aged
- Aging
- Alleles
- Body Composition
- Carrier Proteins
- Estrogen Replacement Therapy
- European Continental Ancestry Group
- Fatty Acid-Binding Protein 7
- Fatty Acid-Binding Proteins
- Female
- Gene Frequency
- Genotype
- Glucose Tolerance Test
- Humans
- Insulin
- Insulin Resistance
- Life Style
- Middle Aged
- Neoplasm Proteins
- Peptidyl-Dipeptidase A
- Physical Fitness
- Postmenopause
- Receptors, Adrenergic
- Receptors, Cytoplasmic and Nuclear
- Transcription Factors
- Tumor Suppressor Proteins