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...xpression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. ...egulated AD subnetwork. Our study highlights that simultaneously analyzing aging and AD will help to understand the pre-clinical and clinical phase of AD an ...

...loss of Atp13a2 causes sensorimotor impairments, α-synuclein accumulation as occurs in PD and related synucleinopathies, and accumulation of lipofuscin * Aging ...

|title=Experience of aging in patients with rheumatic disease: a comparison with the general population. ...nd physical health outcomes and health behavior in patients with rheumatic disease. ...

|title=Lessons from a [[BACE1]] inhibitor trial: off-site but not off base. ...iddle-aged humans would produce effects not detectable in mice. We present a testable model to explain the off-target effects of LY2886721 and highlight ...

|title=Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia. ...creas. Taken together, our data suggest that the apoc2 mutant zebrafish is a robust and versatile animal model to study hypertriglyceridemia and the mec ...

...sease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. ...genes may contribute to the risk of cognitive aging independently as well as through gene-gene and gene-lifestyle interactions. ...

...hed in young blood, [[THBS4]] and [[[[SPARC]]L1]], directly act on neurons as synaptogenic factors. These proteins may represent rejuvenation factors tha * Aging ...

..., including 4.77 for 17q23.2, and 4.36 for 10q11.21. These two loci harbor a number of novel candidate genes with SNPs, and our gene-wise association an |keywords=* aging ...

...nd [[UQCRH]] and [[CYC1]], which form the cyt c(1) subcomplex of CIII; and a gamma chain that is essential for ATP synthesis by CV complex. The extent o |mesh-terms=* Aging ...

...tion are limited to development and that its inhibition adulthood provides a potential path for modulating α-Syn and tau levels. |mesh-terms=* Aging ...

|title=Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study. ...episodic memory and information processing speed. Our results suggest that a minority of AD related SNPs may be associated with non-clinical cognitive d ...

|title=Deafness and retinal degeneration in a novel [[USH1C]] knock-in mouse model. ...ual sensory loss of human Usher I, providing a novel resource to study the disease mechanism and the development of therapies. ...

...EC3B]] p.S106G Mutant in a Caucasian Population of Successful Neurological Aging. ...function will be critical to understand the etiology of neurodegenerative disease and the role of age at risk. ...

...nd [[UQCRH]] and [[CYC1]], which form the cyt c(1) subcomplex of CIII; and a gamma chain that is essential for ATP synthesis by CV complex. The extent o |mesh-terms=* Aging ...

...nd [[UQCRH]] and [[CYC1]], which form the cyt c(1) subcomplex of CIII; and a gamma chain that is essential for ATP synthesis by CV complex. The extent o |mesh-terms=* Aging ...

...deas that are relevant to disease prevention and novel drugs for cognitive aging. * cognitive aging ...

...nd [[UQCRH]] and [[CYC1]], which form the cyt c(1) subcomplex of CIII; and a gamma chain that is essential for ATP synthesis by CV complex. The extent o |mesh-terms=* Aging ...

...changes were age, hormone, and glutamine length dependent and arose due to a toxic gain of function conferred by the mutation. Moreover, altered gene ex |mesh-terms=* Aging ...

|title=Novel [[KRIT1]] mutation and no molecular evidence of anticipation in a family with cerebral and spinal cavernous malformations. ...radient-echo MRI should not only include the cerebrum, but the spinal cord as well. ...

...mokines. Several years ago it was shown that cells can also communicate in a more direct manner by an exchange of proteins via cellular bridges (CBs). R ...decrease in IQ motif-containing GTPase activating protein 1 ([[IQGAP1]]), a key protein associated with maintenance of cytoskeletal integrity. Enhanced ...