KLC1

Kinesin light chain 1 (KLC 1) [KLC] [KNS2]

Publications

Variability in the kinesin light chain 1 gene may influence risk of age-related cataract.

PubMed

Full text

Kinesin-mediated cargo vesicle transport is fundamental to the maintenance of a proper lens fiber structure, which is essential for the transparency of the lens. Here, we test the hypothesis that the rs8702 polymorphism in the kinesin light chain 1 gene (KLC1), previously linked to Alzheimer disease (AD), may play a role in cataractogenesis. Patients with nuclear (n=76), cortical (n=154), posterior subcapsular (n=117), and mixed (n=148) cataract as well as 183 controls were analyzed for the KLC1 rs8702 polymorphism using the dynamic allele-specific hybridization (DASH) technique. The GG genotype of rs8702 was significantly over-represented among cataract patients as compared to controls (63% versus 52%, respectively, p=0.008) and associated with an age-adjusted odds ratio for cataract development of 1.61 (95% confidence interval 1.12-2.31). This association was not confined to any particular cataract type. The KLC1 gene may be a novel susceptibility gene for age-related cataract.

MeSH Terms

• Adult
• Aged
• Aged, 80 and over
• Aging
• Alleles
• Cataract
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Logistic Models
• Male
• Microtubule-Associated Proteins
• Middle Aged
• Nucleic Acid Hybridization
• Odds Ratio
• Polymorphism, Genetic
• Smoking