ELN

Elastin precursor (Tropoelastin)

Publications

Curcumin enhances the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells.

PubMed

Full text

Curcumin is the major component of the yellow extract derived from the rhizome of the Curcuma longa, which is also a main bioactive polyphenol and has been generally used as a spice, food additive, and herbal medicine. In this presented study, we found that curcumin can enhance the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells via increasing ELN and FBN1 promoters' activities. With 2 μM curcumin treatment, the enhanced tropoelastin and fibrillin-1 protein amounts in Detroit 551 cells were approximately 134 and 130% of control, respectively. Therefore, our results demonstrated that curcumin may be used as a functional compound and applied to drugs, foods, and cosmetics in the future.

MeSH Terms

• Aging
• Cell Line
• Curcumin
• Elastic Tissue
• Elastin
• Fibrillin-1
• Fibrillins
• Fibroblasts
• Humans
• Microfilament Proteins
• Promoter Regions, Genetic
• RNA, Messenger
• Tropoelastin

Keywords

• curcumin
• elastin
• fibrillin-1
• fibroblast cells
• promoter activity