RGS5

Regulator of G-protein signaling 5 (RGS5)

Publications

Cardiac myocytes express mRNA for ten RGS proteins: changes in RGS mRNA expression in ventricular myocytes and cultured atria.

PubMed

Full text

Regulators of G-protein signalling (RGS) are recently identified proteins that shorten the lifetime of the activated G protein. We now show that rat cardiac myocytes express mRNA for at least 10 RGS. The mRNA for RGS-r is barely detectable in rat ventricles, but increases more than 20-fold during the 60- to 90-min process of isolating ventricular myocytes, and after 90 min of culture of atrial pieces in medium with Ca2 . Both in myocytes and in atria, the rise in RGS-r is transient. The mRNA for cardiac RGS5, but not RGS-r, is developmentally regulated. These studies suggest that rapid regulation of RGS levels may be a new mechanism that governs how signals are transmitted across the cardiac cell membrane.

MeSH Terms

• Aging
• Animals
• Animals, Newborn
• Cell Membrane
• Cells, Cultured
• Eye Proteins
• GTP-Binding Proteins
• GTPase-Activating Proteins
• Gene Expression Regulation
• Heart
• Heart Atria
• Heart Ventricles
• Kinetics
• Myocardium
• Organ Specificity
• Protein Biosynthesis
• Proteins
• RGS Proteins
• RNA, Messenger
• Rats
• Reverse Transcriptase Polymerase Chain Reaction
• Signal Transduction
• Transcription, Genetic