FMC1
FMC1 homolog (ATP synthase assembly factor FMC1, mitochondrial) (Formation of mitochondrial complex V assembly factor 1 homolog) [C7orf55] [HSPC268]
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Peripheral blood from aging and young humans and patients with Down's syndrome, and from age- and sex-matched controls, was studied for the proportions of surface immunoglobulin (SIg ) bearing and monoclonal antibodies FMC1, and FMC7 defined B lymphocytes and B lymphocyte subsets using fluorescent-activated cell sorter. In aging humans, the proportion of SIg and FMC1 (that detect all B lymphocytes) were comparable to simultaneously studied healthy young controls. However, FMC7 (that detects a subset of B cells) B cells were significantly (p less than 0.05) increased when compared to young subjects. In aging subjects, the proportions of FMC7 B cells were comparable to their FMC1 B cells, whereas in young subjects FMC7 B cells were a subset of FMC1 B cells. In Down's syndrome, a phenomenon similar to aging humans was observed, that is the proportions of FMC7 were increased when compared to age- and sex-matched controls and were comparable to their own FMC1 B cells. This study demonstrates the abnormality of B lymphocytes in human aging and Down's syndrome. The significance of these findings is discussed.
MeSH Terms
- Adult
- Aged
- Aging
- Antibodies, Monoclonal
- B-Lymphocytes
- Child
- Child, Preschool
- Down Syndrome
- Female
- Humans
- Male
- Receptors, Antigen, B-Cell
- Reference Values