RLIM

E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43) [RNF12]

Publications

Development with age of human articular cartilage surface structure. A survey by interference microscopy of the lateral femoral condyle.

PubMed

Full text

The weight-bearing surfaces of the lateral femoral condyles taken from twenty normal human cadavers aged 0-47 years have been examined by reflected light interference microscopy (RLIM) and by scanning electron microscope (SEM). The surfaces appeared normal by naked eye examination. The presence of both 200-400 mum diameter secondary undulations and small ovoid 20-45 mum diameter tertiary hollows was confirmed in all specimens using both techniques. Measurements by RLIM showed that the tertiary hollows increase significantly in depth and diameter with increasing age. A further order of quaternary surface irregularities was shown. Small irregular ridges, 130-275 nm deep and 1-4 mum diameter, were found with increasing frequency on specimens obtained from persons aged 21 years. These quaternary irregularities are thought to be due to exposure of superficial fibre bundles after the loss, with age, of surface ground substance.

MeSH Terms

• Adolescent
• Adult
• Age Factors
• Aging
• Cartilage, Articular
• Child
• Child, Preschool
• Female
• Femur
• Humans
• Infant
• Infant, Newborn
• Knee Joint
• Male
• Methods
• Microscopy, Electron, Scanning
• Microscopy, Interference
• Middle Aged
• Statistics as Topic