FAIM
Fas apoptotic inhibitory molecule 1 [FAIM1]
Publications[править]
During ageing, autoimmune disorders and the higher susceptibility to infectious have been associated with alterations in the humoral immune response. We report that splenic B lymphocytes from aged mice exhibit lower level of apoptosis induced by B-cell antigen receptor (BCR) ligation in vitro. Respect to B cells from young mice the anti-mu stimulated aged B cells show similar Bcl-2 and Bcl-xL expression but differential kinetic of A1 degradation and a higher level of cFLIP and FAIM. Even though B cells from aged mice show minor Fas expression they exhibit the same susceptibility to anti-Fas induced apoptosis. Aged B cells also present upon BCR stimulation, a higher proliferative response and similar level of activation markers expression than B cells from young mice. These data agree with the observation that aged mice exhibit an increment of T2 and mature B cell subset which rapidly enters cell cycle upon BCR engagement. The diminished apoptosis after activation in aged mice could compromise homeostatic mechanism allowing the persistence of self and non-self antigen specific B cells.
MeSH Terms
- Aging
- Animals
- Antigens
- Apoptosis
- Apoptosis Regulatory Proteins
- B-Lymphocyte Subsets
- Biomarkers
- Blotting, Western
- CASP8 and FADD-Like Apoptosis Regulating Protein
- Cell Survival
- Cells, Cultured
- Electrophoresis, Polyacrylamide Gel
- Female
- Flow Cytometry
- Inhibitor of Apoptosis Proteins
- Intracellular Signaling Peptides and Proteins
- Mice
- Mice, Inbred BALB C
- Receptors, Antigen, B-Cell
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction
- Up-Regulation
- fas Receptor