https://transhumanist.ru/index.php?action=history&feed=atom&title=ZNF286BZNF286B - История изменений2026-06-16T01:38:45ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=ZNF286B&diff=5738&oldid=prevOdysseusBot: Новая страница: «zinc finger protein 286B [ZNF286C] [ZNF286L] ==Publications== {{medline-entry |title=FOXO3 gene variants and human aging: coding variants may not be key players...»2021-05-12T13:57:33Z<p>Новая страница: «zinc finger protein 286B [ZNF286C] [ZNF286L] ==Publications== {{medline-entry |title=FOXO3 gene variants and human aging: coding variants may not be key players...»</p>
<p><b>Новая страница</b></p><div>zinc finger protein 286B [ZNF286C] [ZNF286L]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=FOXO3 gene variants and human aging: coding variants may not be key players.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22459618<br />
|abstract=FOXO3 is generally recognized as a "master" gene in aging since its association with longevity has been replicated in multiple organisms and human populations. A group of single nucleotide polymorphisms in linkage disequilibrium with a coding region has been associated with human longevity, but the actual functional variant is unidentified. Therefore, we sequenced the coding region in our long-lived Japanese American population in order to enhance resources for fine mapping this region. We demonstrate that of 38 published variants, 6 are misalignments with homologous nonallelic sequences from [[FOXO3B]] ([[ZNF286B]]), a pseudogene on a different chromosome; 2 are attributable to [[ZNF286B]] only, and the remaining 30 were unconfirmed, indicating that they are very rare and not likely involved in longevity. Furthermore, we identified a novel, unique, nonsynonymous coding variant in exon 3 (Gly566Ala; rs138174682) that is prevalent in multiple ethnic groups but appeared too rare for major longevity effects in our study populations.<br />
|mesh-terms=* Aged<br />
* Aged, 80 and over<br />
* Aging<br />
* Alleles<br />
* Asian Americans<br />
* Case-Control Studies<br />
* Chromosome Mapping<br />
* Cohort Studies<br />
* European Continental Ancestry Group<br />
* Female<br />
* Forkhead Box Protein O3<br />
* Forkhead Transcription Factors<br />
* Genetic Variation<br />
* Humans<br />
* Longevity<br />
* Male<br />
* Middle Aged<br />
* Open Reading Frames<br />
* Polymorphism, Single Nucleotide<br />
* Sensitivity and Specificity<br />
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|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668389<br />
}}</div>OdysseusBot