https://transhumanist.ru/index.php?action=history&feed=atom&title=ZFP36ZFP36 - История изменений2026-05-11T16:51:36ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=ZFP36&diff=5282&oldid=prevOdysseusBot: Новая страница: «mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36...»2021-05-12T13:37:28Z<p>Новая страница: «mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36...»</p>
<p><b>Новая страница</b></p><div>mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) [G0S24] [NUP475] [RNF162A] [TIS11A] [TTP]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/11743719<br />
|abstract=The daf-2 insulin-like receptor pathway regulates development and life-span in Caenorhabditis elegans. Reduced DAF-2 signaling leads to changes in downstream targets via the daf-16 gene, a fork-head transcription factor which is regulated by DAF-2, and results in extended life-span. Here, we describe the first identification of genes whose expression is controlled by the DAF-2 signaling cascade. dao-1, dao-2, dao-3, dao-4, dao-8 and dao-9 are down-regulated in daf-2 mutant adults compared to wild-type adults, whereas dao-5, dao-6 and dao-7 are up-regulated. The latter genes are negatively regulated by DAF-2 signaling and positively regulated by DAF-16. Positive regulation by DAF-2 on dao-1, dao-4 and dao-8 was mediated by DAF-16, whereas daf-16 mediates only part of DAF-2 signaling for dao-2 and dao-9. Regulation by DAF-2 is most likely DAF-16 independent for dao-3 and hsp-90. RNA levels of dao-5 and dao-6 showed elevated expression in daf-2 adults, as well as being strongly expressed in dauer larvae. In contrast, hsp-90 transcript levels are low in daf-2 mutant adults though they are enriched in dauer larvae, indicating overlapping but not identical mechanisms of efficient life maintenance in stress-resistant dauer larvae and long-lived daf-2 mutant adults. dao-1, dao-8 and dao-9 are homologs of the FK506 binding proteins that interact with the mammalian insulin pathway. dao-3 encodes a putative methylenetetrahydrofolate dehydrogenase. [[DAO]]-5 shows 33 % identity with human nucleolar phosphoprotein P130. dao-7 is similar to the mammalian [[ZFP36]] protein. Distinct regulatory patterns of dao genes implicate their diverse positions within the signaling network of DAF-2 pathway, and suggest they have unique contributions to development, metabolism and longevity.<br />
|mesh-terms=* Aging<br />
* Amino Acid Sequence<br />
* Animals<br />
* Base Sequence<br />
* Caenorhabditis elegans<br />
* Caenorhabditis elegans Proteins<br />
* Cloning, Molecular<br />
* Forkhead Transcription Factors<br />
* Gene Expression Profiling<br />
* Gene Expression Regulation<br />
* Genes, Helminth<br />
* Larva<br />
* Molecular Sequence Data<br />
* Multigene Family<br />
* Mutation<br />
* RNA, Double-Stranded<br />
* RNA, Messenger<br />
* Receptor, Insulin<br />
* Reproducibility of Results<br />
* Signal Transduction<br />
* Tacrolimus Binding Proteins<br />
* Transcription Factors<br />
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|full-text-url=https://sci-hub.do/10.1006/jmbi.2000.5210<br />
}}</div>OdysseusBot