https://transhumanist.ru/index.php?action=history&feed=atom&title=UVSSAUVSSA - История изменений2026-06-17T23:35:49ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=UVSSA&diff=3996&oldid=prevOdysseusBot: Новая страница: «UV-stimulated scaffold protein A [KIAA1530] ==Publications== {{medline-entry |title=A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVS...»2021-04-29T18:55:31Z<p>Новая страница: «UV-stimulated scaffold protein A [KIAA1530] ==Publications== {{medline-entry |title=A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVS...»</p>
<p><b>Новая страница</b></p><div>UV-stimulated scaffold protein A [KIAA1530]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=A C. elegans homolog for the UV-hypersensitivity syndrome disease gene [[UVSSA]].<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27043179<br />
|abstract=The transcription-coupled repair pathway (TC-NER) plays a vital role in removing transcription-blocking DNA lesions, particularly UV-induced damage. Clinical symptoms of the two TC-NER-deficiency syndromes, Cockayne syndrome (CS) and UV-hypersensitivity syndrome (UVSS) are dissimilar and the underlying molecular mechanism causing this difference in disease pathology is not yet clearly understood. UV-stimulated scaffold protein A ([[UVSSA]]) has been identified recently as a new causal gene for UVSS. Here we describe a functional homolog of the human [[UVSSA]] gene in the nematode Caenorhabditis elegans, uvs-1 ([[UVSSA]]-like-1). Mutations in uvs-1 render the animals hypersensitive to UV-B irradiation and transcription-blocking lesion-inducing illudin-M, similar to mutations in TC-NER deficient mutants. Moreover, we demonstrate that TC-NER factors including UVS-1 are required for the survival of the adult animals after UV-treatment.<br />
|mesh-terms=* Animals<br />
* Caenorhabditis elegans<br />
* Caenorhabditis elegans Proteins<br />
* Carrier Proteins<br />
* DNA Repair<br />
* Humans<br />
* Longevity<br />
* Mutation<br />
* Oxidative Stress<br />
* Polycyclic Sesquiterpenes<br />
* Sequence Homology, Nucleic Acid<br />
* Sesquiterpenes<br />
* Transcription, Genetic<br />
* Ultraviolet Rays<br />
|keywords=* C. elegans<br />
* Cockayne syndrome<br />
* DNA damage<br />
* Nucleotide excision repair<br />
* UV-hypersensitivity syndrome<br />
* Ultraviolet light<br />
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886821<br />
}}</div>OdysseusBot