https://transhumanist.ru/index.php?action=history&feed=atom&title=USP8 2026-08-22T10:32:56Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=USP8&diff=4173&oldid=prev 2021-04-29T19:04:22Z

<p>Новая страница: «Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specif...»</p> <p><b>Новая страница</b></p><div>Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) [KIAA0055] [UBPY]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Inhibition of the deubiquitinase [[USP8]] corrects a Drosophila [[PINK1]] model of mitochondria dysfunction.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30988163<br /> |abstract=Aberrant mitochondrial dynamics disrupts mitochondrial function and contributes to disease conditions. A targeted RNA interference screen for deubiquitinating enzymes (DUBs) affecting protein levels of multifunctional mitochondrial fusion protein Mitofusin (MFN) identified [[USP8]] prominently influencing MFN levels. Genetic and pharmacological inhibition of [[USP8]] normalized the elevated MFN protein levels observed in [[PINK1]] and Parkin-deficient models. This correlated with improved mitochondrial function, locomotor performance and life span, and prevented dopaminergic neurons loss in [i]Drosophila[/i] [[PINK1]] KO flies. We identified a novel target antagonizing pathologically elevated MFN levels, mitochondrial dysfunction, and dopaminergic neuron loss of a [i]Drosophila[/i] model of mitochondrial dysfunction.<br /> |mesh-terms=* Animals<br /> * Cell Line<br /> * Dimethyl Sulfoxide<br /> * Dopamine<br /> * Dopaminergic Neurons<br /> * Down-Regulation<br /> * Drosophila<br /> * Drosophila Proteins<br /> * Drosophila melanogaster<br /> * Gene Silencing<br /> * Longevity<br /> * Male<br /> * Membrane Proteins<br /> * Mitochondria<br /> * Parkinson Disease<br /> * Phenotype<br /> * Protein-Serine-Threonine Kinases<br /> * Signal Transduction<br /> * Transfection<br /> * Ubiquitin-Protein Ligases<br /> * Ubiquitin-Specific Proteases<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467245<br /> }}</div>

OdysseusBot