https://transhumanist.ru/index.php?action=history&feed=atom&title=ULK2 2026-04-14T03:19:03Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ULK2&diff=4375&oldid=prev 2021-04-29T19:14:54Z

<p>Новая страница: «Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) [KIAA0623] ==Publications== {{medline-entry |title=miR-26a suppresses autophagy in swi...»</p> <p><b>Новая страница</b></p><div>Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) [KIAA0623]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=miR-26a suppresses autophagy in swine Sertoli cells by targeting [[ULK2]].<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29761550<br /> |abstract=A large number of microRNAs (miRNAs) have been detected from porcine testicular tissues thanks to the development of high-throughput sequencing technology. However, the regulatory roles of most identified miRNAs in swine testicular development or spermatogenesis are poorly understood. In our previous study, [[ULK2]] (uncoordinated-51-like kinase 2) was predicted as a target gene of miR-26a. In this study, we aimed to investigate the role of miR-26a in swine Sertoli cell autophagy. The relative expression of miR-26a and [[ULK2]] levels has a significant negative correlation (R  = .5964, p ≤ .01) in nine developmental stages of swine testicular tissue. Dual-luciferase reporter assay results show that miR-26a directly targets the 3&#039;UTR of the [[ULK2]] gene (position 618-624). In addition, both the mRNA and protein expression of [[ULK2]] were downregulated by miR-26a in swine Sertoli cells. These results indicate that miR-26a targets the [[ULK2]] gene and downregulates its expression in swine Sertoli cells. Based on the expression of marker genes (LC3, p62 and Beclin-1), overexpression of miR-26a or knock-down of [[ULK2]] inhibits swine Sertoli cell autophagy. Taken together, these findings demonstrate that miR-26a suppresses autophagy in swine Sertoli cells by targeting [[ULK2]].<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Autophagy<br /> * Gene Expression Regulation, Developmental<br /> * Gene Expression Regulation, Enzymologic<br /> * Gene Knockdown Techniques<br /> * Male<br /> * MicroRNAs<br /> * Protein-Serine-Threonine Kinases<br /> * Sertoli Cells<br /> * Swine<br /> |keywords=* <br /> ULK2<br /> <br /> * autophagy<br /> * expression<br /> * miR-26a<br /> * swine Sertoli cells<br /> |full-text-url=https://sci-hub.do/10.1111/rda.13177<br /> }}</div>

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