https://transhumanist.ru/index.php?action=history&feed=atom&title=UGT2B15 2026-06-20T20:13:53Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=UGT2B15&diff=5148&oldid=prev 2021-05-12T13:31:17Z

<p>Новая страница: «UDP-glucuronosyltransferase 2B15 precursor (EC 2.4.1.17) (UDPGT 2B15) (UGT2B15) (HLUG4) (UDP-glucuronosyltransferase 2B8) (UDPGT 2B8) (UDPGTh-3) [UGT2B8] ==Publi...»</p> <p><b>Новая страница</b></p><div>UDP-glucuronosyltransferase 2B15 precursor (EC 2.4.1.17) (UDPGT 2B15) (UGT2B15) (HLUG4) (UDP-glucuronosyltransferase 2B8) (UDPGT 2B8) (UDPGTh-3) [UGT2B8]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17698910<br /> |abstract=Previous in vitro studies have demonstrated that the UDP glucuronosyltransferase (UGT)2B15 and [[UGT2B17]] glucuronidate androgens and their metabolites. Our objective was to determine in vivo whether the [[UGT2B15]] D85Y and the [[UGT2B17]] deletion polymorphisms predict androgen glucuronidation and body composition. Two population-based cohorts including young adult (n = 1068; age = 18.9 yr) and elderly (n = 1001; age = 75.3 yr) men were included in the study. Serum and urine levels of testosterone (T) and dihydrotestosterone (DHT) were measured by gas chromatography-mass spectrometry, and serum levels of the major glucuronidated androgen metabolites androstane-3alpha,17beta-diol(androstanediol)-3-glucuronide, androstanediol-17-glucuronide, and androsterone-glucuronide were measured by liquid chromatography-tandem mass spectrometry. Body composition was measured by dual-energy x-ray absorptiometry. Both the [[UGT2B15]] D85Y and the [[UGT2B17]] deletion polymorphisms were associated with serum levels of androstanediol-17-glucuronide (P &lt; 0.001) but not with levels of androstanediol-3-glucuronide or androsterone-glucuronide in both cohorts. Glucuronidation of T and DHT was associated with the [[UGT2B17]] deletion but not with the [[UGT2B15]] D85Y polymorphism, suggested by strong associations between the deletion polymorphism and urine levels of these two hormones. Both polymorphisms were associated with several different measures of fat mass (P &lt; 0.01). The [[UGT2B17]] deletion polymorphism was associated with insulin sensitivity (P &lt; 0.05) as indicated by the homeostasis model assessment index. The [[UGT2B15]] D85Y and the [[UGT2B17]] deletion polymorphisms are both predictors of the glucuronidation pattern of androgens/androgen metabolites. Our findings indicate that [[UGT2B17]] is involved in 17-glucuronidation of mainly T but also of DHT and androstanediol and that [[UGT2B15]] is involved in the 17-glucuronidation of androstanediol. Furthermore, these two polymorphisms are predictors of fat mass in men.<br /> |mesh-terms=* Absorptiometry, Photon<br /> * Adiposity<br /> * Adolescent<br /> * Adult<br /> * Aged<br /> * Aging<br /> * Androgens<br /> * Blood Glucose<br /> * Body Composition<br /> * Gene Deletion<br /> * Glucuronides<br /> * Glucuronosyltransferase<br /> * Gonadal Steroid Hormones<br /> * Humans<br /> * Insulin<br /> * Insulin Resistance<br /> * Male<br /> * Polymorphism, Genetic<br /> * Sex Hormone-Binding Globulin<br /> <br /> |full-text-url=https://sci-hub.do/10.1210/jc.2007-0359<br /> }}</div>

OdysseusBot