https://transhumanist.ru/index.php?action=history&feed=atom&title=UGT1A7 2026-06-10T03:21:14Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=UGT1A7&diff=5344&oldid=prev 2021-05-12T13:40:00Z

<p>Новая страница: «UDP-glucuronosyltransferase 1A7 precursor (EC 2.4.1.17) (UGT1A7) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransf...»</p> <p><b>Новая страница</b></p><div>UDP-glucuronosyltransferase 1A7 precursor (EC 2.4.1.17) (UGT1A7) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) [GNT1] [UGT1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Microsomal quercetin glucuronidation in rat small intestine depends on age and segment.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21543555<br /> |abstract=UDP-glucuronosyltransferase (UGT) activity toward the flavonoid quercetin and UGT protein were characterized in three equidistant small intestine ([[SI]]) segments from 4-, 12-, 18-, and 28-month-old male Fischer 344 rats (n = 8/age) using villin to control for enterocyte content. [[SI]] microsomal intrinsic clearance of quercetin was increased 3- to 9-fold from 4 months in the proximal and distal [[SI]] at 12 and 18 months. Likewise, at 30 μM quercetin, [[SI]] microsomal glucuronidation activity was increased with age: 4.8- and 3.9-fold greater at 18 months than at 4 months. Quercetin UGT regioselectivity was not changed by age. The distal [[SI]] preferentially catalyzed glucuronidation at the 7-position, whereas the proximal [[SI]] produced the greatest proportion of 4&#039;- and 3&#039;-conjugates. Enterocyte UGT content in different [[SI]] segments was not consistently changed with age. In the proximal [[SI]], UGT1A increased 64 and 150% at 12 and 18 months and [[UGT1A1]], [[UGT1A7]], and [[UGT1A8]] were also increased at 12 and 18 months. However, age-related changes in expression were inconsistent in the medial and distal segments. Microsomal rates of quercetin glucuronidation and UGT expression were positively correlated with [[UGT1A1]] content for all pooled samples (r = 0.467) and at each age (r = 0.538-0.598). [[UGT1A7]] was positively correlated with total, 7-O- and 3-O-quercetin glucuronidation at 18 months. Thus, age-related differences in UGT quercetin glucuronidation depend on intestinal segment, are more pronounced in the proximal and distal segments and may be partially related to [[UGT1A1]] and [[UGT1A7]] content.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Blotting, Western<br /> * Chromatography, High Pressure Liquid<br /> * Dose-Response Relationship, Drug<br /> * Enterocytes<br /> * Glucuronides<br /> * Glucuronosyltransferase<br /> * Intestinal Mucosa<br /> * Intestine, Small<br /> * Male<br /> * Microsomes<br /> * Quercetin<br /> * Rats<br /> * Rats, Inbred F344<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141883<br /> }}</div>

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