https://transhumanist.ru/index.php?action=history&feed=atom&title=UCN3 2026-06-06T18:25:21Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=UCN3&diff=4735&oldid=prev 2021-04-29T19:32:28Z

<p>Новая страница: «Urocortin-3 precursor (Stresscopin) (Urocortin III) (Ucn III) [SPC] ==Publications== {{medline-entry |title=Urocortin 3 signalling in the auditory brainstem aid...»</p> <p><b>Новая страница</b></p><div>Urocortin-3 precursor (Stresscopin) (Urocortin III) (Ucn III) [SPC]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Urocortin 3 signalling in the auditory brainstem aids recovery of hearing after reversible noise-induced threshold shift.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31270820<br /> |abstract=Ongoing, moderate noise exposure does not instantly damage the auditory system but may cause lasting deficits, such as elevated thresholds and accelerated ageing of the auditory system. The neuromodulatory peptide urocortin-3 ([[UCN3]]) is involved in the body&#039;s recovery from a stress response, and is also expressed in the cochlea and the auditory brainstem. Lack of [[UCN3]] facilitates age-induced hearing loss and causes permanently elevated auditory thresholds following a single 2 h noise exposure at moderate intensities. Outer hair cell function in mice lacking [[UCN3]] is unaffected, so that the observed auditory deficits are most likely due to inner hair cell function or central mechanisms. Highly specific, rather than ubiquitous, expression of [[UCN3]] in the brain renders it a promising candidate for designing drugs to ameliorate stress-related auditory deficits, including recovery from acoustic trauma. Environmental acoustic noise is omnipresent in our modern society, with sound levels that are considered non-damaging still causing long-lasting or permanent changes in the auditory system. The small neuromodulatory peptide urocortin-3 ([[UCN3]]) is the endogenous ligand for corticotropin-releasing factor receptor type 2 and together they are known to play an important role in stress recovery. [[UCN3]] expression has been observed in the auditory brainstem, but its role remains unclear. Here we describe the detailed distribution of [[UCN3]] expression in the murine auditory brainstem and provide evidence that [[UCN3]] is expressed in the synaptic region of inner hair cells in the cochlea. We also show that mice with deficient [[UCN3]] signalling experience premature ageing of the auditory system starting at an age of 4.7 months with significantly elevated thresholds of auditory brainstem responses ([[ABR]]s) compared to age-matched wild-type mice. Following a single, 2 h exposure to moderate (84 or 94 dB SPL) noise, [[UCN3]]-deficient mice exhibited significantly larger shifts in [[ABR]] thresholds combined with maladaptive recovery. In wild-type mice, the same noise exposure did not cause lasting changes to auditory thresholds. The presence of [[UCN3]]-expressing neurons throughout the auditory brainstem and the predisposition to hearing loss caused by preventing its normal expression suggests [[UCN3]] as an important neuromodulatory peptide in the auditory system&#039;s response to loud sounds.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Auditory Threshold<br /> * Evoked Potentials, Auditory, Brain Stem<br /> * Female<br /> * Hair Cells, Auditory, Outer<br /> * Hearing Loss, Noise-Induced<br /> * Male<br /> * Mice<br /> * Mice, Inbred C57BL<br /> * Mice, Knockout<br /> * Mice, Transgenic<br /> * Noise<br /> * Signal Transduction<br /> * Urocortins<br /> |keywords=* Corticotropin-releasing hormone receptor<br /> * DPOAEs<br /> * acoustic trauma<br /> * ageing<br /> * auditory brainstem responses<br /> * neuropeptide<br /> * stress recovery<br /> * urocortin<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852351<br /> }}</div>

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