https://transhumanist.ru/index.php?action=history&feed=atom&title=UBQLNLUBQLNL - История изменений2026-11-08T18:56:10ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=UBQLNL&diff=5435&oldid=prevOdysseusBot: Новая страница: «protein ==Publications== {{medline-entry |title=Genotype×age interaction in human transcriptional ageing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22871458...»2021-05-12T13:43:53Z<p>Новая страница: «protein ==Publications== {{medline-entry |title=Genotype×age interaction in human transcriptional ageing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22871458...»</p>
<p><b>Новая страница</b></p><div>protein<br />
<br />
==Publications==<br />
<br />
{{medline-entry<br />
|title=Genotype×age interaction in human transcriptional ageing.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22871458<br />
|abstract=Individual differences in biological ageing (i.e., the rate of physiological response to the passage of time) may be due in part to genotype-specific variation in gene action. However, the sources of heritable variation in human age-related gene expression profiles are largely unknown. We have profiled genome-wide expression in peripheral blood mononuclear cells from 1240 individuals in large families and found 4472 human autosomal transcripts, representing ~4349 genes, significantly correlated with age. We identified 623 transcripts that show genotype by age interaction in addition to a main effect of age, defining a large set of novel candidates for characterization of the mechanisms of differential biological ageing. We applied a novel SNP genotype × age interaction test to one of these candidates, the ubiquilin-like gene [[UBQLNL]], and found evidence of joint cis-association and genotype by age interaction as well as trans-genotype by age interaction for [[UBQLNL]] expression. Both [[UBQLNL]] expression levels at recruitment and cis genotype are associated with longitudinal cancer risk in our study cohort.<br />
|mesh-terms=* Adult<br />
* Age Factors<br />
* Aged<br />
* Aging<br />
* Child<br />
* Child, Preschool<br />
* Female<br />
* Follow-Up Studies<br />
* Gene Expression Regulation<br />
* Genome-Wide Association Study<br />
* Genotype<br />
* Humans<br />
* Infant<br />
* Infant, Newborn<br />
* Male<br />
* Mexican Americans<br />
* Middle Aged<br />
* Neoplasms<br />
* Risk Factors<br />
* Texas<br />
* Transcription, Genetic<br />
<br />
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541784<br />
}}</div>OdysseusBot