https://transhumanist.ru/index.php?action=history&feed=atom&title=TYRP1 2026-04-29T16:27:31Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=TYRP1&diff=4539&oldid=prev 2021-04-29T19:22:57Z

<p>Новая страница: «5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (EC 1.14.18.-) (DHICA oxidase) (Catalase B) (Glycoprotein 75) (Melanoma antigen gp75) (Tyrosinase-related...»</p> <p><b>Новая страница</b></p><div>5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (EC 1.14.18.-) (DHICA oxidase) (Catalase B) (Glycoprotein 75) (Melanoma antigen gp75) (Tyrosinase-related protein 1) (TRP) (TRP-1) (TRP1) [CAS2] [TYRP] [TYRRP]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Thymocid , a Standardized Black Cumin ([i]Nigella sativa[/i]) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32707654<br /> |abstract=Black cumin ([i]Nigella sativa[/i]) seed extract has been shown to improve dermatological conditions, yet its beneficial effects for skin are not fully elucidated. Herein, Thymocid , a chemically standardized black cumin seed extract, was investigated for its cosmeceutical potential including anti-aging properties associated with modulation of glycation, collagen cross-linking, and collagenase and elastase activities, as well as antimelanogenic effect in murine melanoma B16F10 cells. Thymocid (50, 100, and 300 µg/mL) inhibited the formation of advanced glycation end-products (by 16.7-70.7%), collagen cross-linking (by 45.1-93.3%), collagenase activity (by 10.4-92.4%), and elastases activities (type I and III by 25.3-75.4% and 36.0-91.1%, respectively). In addition, Thymocid (2.5-20 µg/mL) decreased melanin content in B16F10 cells by 42.5-61.6% and reduced cellular tyrosinase activity by 20.9% (at 20 µg/mL). Furthermore, Thymocid (20 µg/mL for 72 h) markedly suppressed the mRNA expression levels of melanogenesis-related genes including microphthalmia-associated transcription factor ([i][[MITF]][/i]), tyrosinase-related protein 1 ([i][[TYRP1]][/i]), and [i]TYRP2[/i] to 78.9%, 0.3%, and 0.2%, respectively. Thymocid (10 µg/mL) also suppressed the protein expression levels of [[MITF]] (by 15.2%) and [[TYRP1]] (by 97.7%). Findings from this study support the anti-aging and antimelanogenic potential of Thymocid as a bioactive cosmeceutical ingredient for skin care products.<br /> <br /> |keywords=* Nigella sativa<br /> * Thymocid®<br /> * black cumin<br /> * collagen<br /> * collagenase<br /> * cosmeceutical<br /> * elastase<br /> * glycation<br /> * melanogenesis<br /> * skin aging<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400895<br /> }}</div>

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