https://transhumanist.ru/index.php?action=history&feed=atom&title=TUBTUB - История изменений2026-09-01T05:13:33ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=TUB&diff=5382&oldid=prevOdysseusBot: Новая страница: «Tubby protein homolog ==Publications== {{medline-entry |title=C. elegans tubby regulates life span and fat storage by two independent mechanisms. |pubmed-url=ht...»2021-05-12T13:41:35Z<p>Новая страница: «Tubby protein homolog ==Publications== {{medline-entry |title=C. elegans tubby regulates life span and fat storage by two independent mechanisms. |pubmed-url=ht...»</p>
<p><b>Новая страница</b></p><div>Tubby protein homolog<br />
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==Publications==<br />
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{{medline-entry<br />
|title=C. elegans tubby regulates life span and fat storage by two independent mechanisms.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16054097<br />
|abstract=In C. elegans, similar to in mammals, mutations in the tubby homolog, tub-1, promote increased fat deposition. Here, we show that mutation in tub-1 also leads to life span extension dependent on daf-16/FOXO. Interestingly, function of tub-1 in fat storage is independent of daf-16. A yeast two-hybrid screen identified a novel [[TUB]]-1 interaction partner (RBG-3); a RabGTPase-activating protein. Both [[TUB]]-1 and RBG-3 localize to overlapping neurons. Importantly, RNAi of rbg-3 decreases fat deposition in tub-1 mutants but does not affect life span. We demonstrate that [[TUB]]-1 is expressed in ciliated neurons and undergoes both dendritic and ciliary transport. Additionally, tub-1 mutants are chemotaxis defective. Thus, tub-1 may regulate fat storage either by modulating transport, sensing, or responding to signals in ciliated neurons. Taken together, we define a role for tub-1 in regulation of life span and show that tub-1 regulates life span and fat storage by two independent mechanisms.<br />
|mesh-terms=* Adipose Tissue<br />
* Amino Acid Sequence<br />
* Animals<br />
* Caenorhabditis elegans<br />
* Caenorhabditis elegans Proteins<br />
* Chemotaxis<br />
* Cilia<br />
* Forkhead Transcription Factors<br />
* Insulin<br />
* Insulin-Like Growth Factor I<br />
* Lipid Metabolism<br />
* Longevity<br />
* Models, Biological<br />
* Molecular Sequence Data<br />
* Mutation<br />
* Neurons<br />
* Protein Binding<br />
* Protein Transport<br />
* RNA Interference<br />
* Sequence Alignment<br />
* Transcription Factors<br />
* rab GTP-Binding Proteins<br />
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|full-text-url=https://sci-hub.do/10.1016/j.cmet.2005.06.004<br />
}}</div>OdysseusBot